2016
B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS
Semler MW, Marney AM, Rice TW, Nian H, Yu C, Wheeler AP, Brown NJ, Network N. B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS. CHEST Journal 2016, 150: 102-111. PMID: 27018313, PMCID: PMC4980545, DOI: 10.1016/j.chest.2016.03.017.Peer-Reviewed Original ResearchConceptsB-type natriuretic peptideAcute respiratory distress syndromeConservative fluid managementRespiratory distress syndromeLiberal fluid managementVentilator-free daysNatriuretic peptideFluid managementDistress syndromeAldosterone concentrationOverall mortalityB-type natriuretic peptide concentrationsCatheter Treatment TrialNatriuretic peptide concentrationsLow aldosterone concentrationsHospital mortalityMedian aldosteroneMultivariable analysisStudy enrollmentTreatment trialsPlasma concentrationsRetrospective analysisFluid balanceAldosteroneFluid strategy
2012
Comparative Effects of Angiotensin Receptor Blockade and ACE Inhibition on the Fibrinolytic and Inflammatory Responses to Cardiopulmonary Bypass
Billings F, Balaguer J, Yu C, Wright P, Petracek M, Byrne J, Brown N, Pretorius M. Comparative Effects of Angiotensin Receptor Blockade and ACE Inhibition on the Fibrinolytic and Inflammatory Responses to Cardiopulmonary Bypass. Clinical Pharmacology & Therapeutics 2012, 91: 1065-1073. PMID: 22549281, PMCID: PMC3822756, DOI: 10.1038/clpt.2011.356.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin II Type 1 Receptor BlockersAngiotensin-Converting Enzyme InhibitorsBenzimidazolesBiphenyl CompoundsBlood TransfusionBradykininCardiopulmonary BypassEndpoint DeterminationFemaleFibrinolysisHematocritHospital MortalityHumansInflammationInterleukinsLength of StayMaleMiddle AgedMonitoring, IntraoperativePerioperative CarePostoperative ComplicationsRamiprilTetrazolesTreatment OutcomeConceptsAngiotensin II type 1 receptor blockadeACE inhibitionCardiopulmonary bypassReceptor blockadeInflammatory responseType 1 receptor blockadeTissue-type plasminogen activator concentrationAngiotensin receptor blockadeEffect of angiotensinRed cell transfusionDay of surgeryPlasminogen activator inhibitor-1Activator inhibitor-1Plasminogen activator concentrationsHospital stayPlasma transfusionIL-10ACE inhibitorsIL-8Intraoperative fibrinolysisFibrinolysisInhibitor-1Comparative effectsPlaceboTransfusion