2011
Pain Relief in Laparoscopic Cholecystectomy—A Review of the Current Options
Mitra S, Khandelwal P, Roberts K, Kumar S, Vadivelu N. Pain Relief in Laparoscopic Cholecystectomy—A Review of the Current Options. Pain Practice 2011, 12: 485-496. PMID: 22008277, DOI: 10.1111/j.1533-2500.2011.00513.x.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsLocal anestheticsLaparoscopic cholecystectomyPain reliefTransversus abdominis plane blockCardiovascular adverse effectsPort-site infiltrationIntra-operative periodSingle modality interventionsFavorable pharmacological characteristicsAnti-inflammatory drugsCOX-2 inhibitorsCyclooxygenase-2 inhibitorNSAID/COXTAP blockNoncardiac surgeryPlane blockSafe analgesiaEarly instillationIntraperitoneal instillationPharmacological characteristicsFibrin sealantInstillationCurrent optionsAdverse effects
2005
Recent advances in elucidating pain mechanisms
Vadivelu N, Sinatra R. Recent advances in elucidating pain mechanisms. Current Opinion In Anaesthesiology 2005, 18: 540. PMID: 16534290, DOI: 10.1097/01.aco.0000183109.27297.75.Peer-Reviewed Original ResearchCentral sensitizationPain mechanismsChronic painN-methyl-D-asparate antagonistNon-opioid medicationsSpinal cord hyperexcitabilityCyclooxygenase-2 inhibitorNew synaptic connectionsSecondary hyperalgesiaOpioid medicationsPain controlPain syndromeNerve injuryPain modulationPain statesNociceptor sensitizationNeural injuryNew opioidSecond messenger systemsNervous systemAcute tissueSynaptic connectionsReceptor systemMessenger systemsSensitization