2024
The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro J, Narula S, Brenton J, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas J, de Seze J, Tenembaum S, Stone R, Casez O, Carra-Dallière C, Neuteboom R, Ahsan N, Arroyo H, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich D, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo C, Kantarci O, Shapiro E, Okuda D, Pelletier D. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. Journal Of Neurology 2024, 271: 4019-4027. PMID: 38564056, PMCID: PMC11323224, DOI: 10.1007/s00415-024-12289-1.Peer-Reviewed Original ResearchRadiologically isolated syndromeSpinal MRIDiagnostic workup of childrenMultiple sclerosisWorkup of childrenFisher's exact testMultivariate logistic regressionInternational longitudinal studyDiagnostic workupConsensus guidelinesExact testMS riskLogistic regressionConclusionsYoung childrenCSFBackgroundCerebrospinal fluidMRIPre-2017Longitudinal studySyndromeRadiologyChildrenAgeSexRisk
2020
Multiple Sclerosis in Children: Current and Emerging Concepts
Brenton JN, Kammeyer R, Gluck L, Schreiner T, Makhani N. Multiple Sclerosis in Children: Current and Emerging Concepts. Seminars In Neurology 2020, 40: 192-200. PMID: 32294785, PMCID: PMC8514113, DOI: 10.1055/s-0040-1703000.Peer-Reviewed Original Research
2018
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis
Aaen G, Waltz M, Vargas W, Makhani N, Ness J, Harris Y, Casper TC, Benson L, Candee M, Chitnis T, Gorman M, Graves J, Greenberg B, Lotze T, Mar S, Tillema JM, Rensel M, Rodriguez M, Rose J, Rubin J, Schreiner T, Waldman A, Weinstock-Guttman B, Belman A, Waubant E, Krupp L. Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. Journal Of Child Neurology 2018, 34: 148-152. PMID: 30556452, PMCID: PMC6579723, DOI: 10.1177/0883073818815041.Peer-Reviewed Original ResearchConceptsPediatric multiple sclerosisMultiple sclerosisEarly developmental milestonesPediatric Multiple Sclerosis CentersPediatric-onset multiple sclerosisMultiple sclerosis onsetMultiple Sclerosis CenterDevelopmental milestonesPediatric controlsDisease onsetHealthy controlsSclerosisAge 18Age 11ChildrenOnsetIndividualized education planFurther researchControl
2017
Radiologically isolated syndrome in children
Makhani N, Lebrun C, Siva A, Brassat D, Carra Dallière C, de Seze J, Du W, Durand Dubief F, Kantarci O, Langille M, Narula S, Pelletier J, Rojas JI, Shapiro ED, Stone RT, Tintoré M, Uygunoglu U, Vermersch P, Wassmer E, Okuda DT, Pelletier D. Radiologically isolated syndrome in children. Neurology Neuroimmunology & Neuroinflammation 2017, 4: &na;. PMID: 28959703, PMCID: PMC5614726, DOI: 10.1212/nxi.0000000000000395.Peer-Reviewed Original ResearchFirst clinical eventSpinal cord lesionsCNS demyelinationClinical eventsCord lesionsOligoclonal bandsRadiologic evolutionIncidental MRI findingsSubsequent clinical symptomsOutcome of childrenInitial neuroimagingMean followClinical characteristicsRadiologic outcomesMRI findingsClinical symptomsHistorical cohortRadiologic dataMRI criteriaIncidental findingCommon reasonMRI scansDemyelinationSubstantial riskChildrenGenetic and Environmental Risk Factors for Pediatric Multiple Sclerosis
Makhani N, George I. Genetic and Environmental Risk Factors for Pediatric Multiple Sclerosis. Journal Of Pediatric Neurology 2017, 16: 141-147. DOI: 10.1055/s-0037-1604339.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEnvironmental risk factorsMultiple sclerosisRisk factorsLow serum vitamin D levelsSerum vitamin D levelsNon-HLA single nucleotide polymorphismsVitamin D levelsPediatric multiple sclerosisEpstein-Barr virusHuman leukocyte antigenDifferent risk factorsGenetic risk factorsD levelsLeukocyte antigenParental smokingPrior exposureSingle nucleotide polymorphismsSclerosisCurrent literatureNucleotide polymorphismsChildrenFactorsSmokingAntigenDisease
2015
Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination
Makhani N, Banwell B, Tellier R, Yea C, McGovern S, O’Mahony J, Ahorro JM, Arnold D, Sadovnick AD, Marrie RA, Bar-Or A, Network O. Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination. Multiple Sclerosis Journal 2015, 22: 385-388. PMID: 26199356, DOI: 10.1177/1352458515595876.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralChickenpoxChildCohort StudiesCytomegalovirus InfectionsDemyelinating DiseasesEnzyme-Linked Immunosorbent AssayEpstein-Barr Virus InfectionsFemaleHerpes SimplexHumansImmunoglobulin GMaleMultiple SclerosisProportional Hazards ModelsProspective StudiesSeroepidemiologic StudiesConceptsCMV infectionEpstein-Barr virus infectionRemote EBV infectionSubsequent MS diagnosisImportant prognostic informationMultiple sclerosis riskVaricella-zoster virusHerpes simplex virusCMV seroprevalenceDemyelinating syndromesMonophasic ADSEBV infectionCytomegalovirus infectionProspective cohortMS diagnosisViral exposurePrognostic informationMS outcomesVirus infectionHigh riskSimplex virusMS developmentInfectionProtective factorsChildren