2020
Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways
Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA, Program N. Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. Journal Of Allergy And Clinical Immunology 2020, 147: 894-909. PMID: 32795586, PMCID: PMC7876167, DOI: 10.1016/j.jaci.2020.07.030.Peer-Reviewed Original ResearchConceptsExpression quantitative trait loci (eQTL) analysisQuantitative trait locus (QTL) analysisSingle nucleotide polymorphismsGasdermin BMultiple single nucleotide polymorphismsFunctional genesExpression levelsLocus analysisAntiviral pathwaysGenes/single-nucleotide polymorphismsWhole genome sequencesGene expression dataEpithelial cellsImmune system pathwaysHigh expression levelsHuman bronchial epithelial cellsIFN regulatory factorGPI attachmentGSDMB expressionAsthma susceptibilityGenetic analysisGene expressionPathway analysisBronchial epithelial cellsRegulatory factors
2019
High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report
Hersh CP, Adcock IM, Celedón JC, Cho MH, Christiani DC, Himes BE, Kaminski N, Mathias RA, Meyers DA, Quackenbush J, Redline S, Steiling KA, Tabor HK, Tobin MD, Wurfel MM, Yang IV, Koppelman GH. High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2019, 16: 1-16. PMID: 30592451, PMCID: PMC6812157, DOI: 10.1513/annalsats.201810-716ws.Peer-Reviewed Original ResearchMeSH KeywordsCritical CareHigh-Throughput Nucleotide SequencingHumansPulmonary MedicineSleep Medicine SpecialtySocieties, MedicalUnited StatesWhole Genome SequencingConceptsCritical careSleep medicine researchAmerican Thoracic Society meetingOfficial American Thoracic Society Workshop ReportCommon chronic diseasesMedicine researchNonmalignant diseasesLung cancerChronic diseasesPractice guidelinesRespiratory diseaseBest practice guidelinesSleep medicineStudy designDiseaseWorkshop reportCareReporting of resultsRelevant diseasesSingle-day workshopMonogenic diseasesGenetic epidemiologyReportReview articleSociety meetings