Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics
Steinman JB, Lum FM, Ho PP, Kaminski N, Steinman L. Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 24620-24626. PMID: 32883878, PMCID: PMC7547272, DOI: 10.1073/pnas.2012358117.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptorT helper 2 (Th2) immune responsesCross-reactive humoral immunityCOVID-19T cell immunityT helper 2SARS-CoV-2Cell immunityCommon coronavirusesHelper 2Humoral immunityInflammatory cytokinesRespiratory tractImmune responseCommon coldPandemic virusPotential therapeuticsChildrenPathogenesisImmunityReduced developmentMolecular checkpointsCoronavirusLow levelsEosinophilia