2019
Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis
Ryu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. European Respiratory Journal 2019, 54: 1801762. PMID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.Peer-Reviewed Original ResearchConceptsExtrapulmonary diseaseMitochondrial DNAExtracellular mtDNABAL fluidAlpha-1 antitrypsin deficiencyPlasma mitochondrial DNAPlasma of patientsAfrican AmericansExtrapulmonary sarcoidosisSarcoidosis cohortSarcoidosis subjectsScadding stageAfrican American descentClinical featuresClinical findingsGranulomatous diseaseHealthy controlsAntitrypsin deficiencyGenomic researchHigher oddsSarcoidosisAggressive phenotypeMechanistic basisDiseaseTherapeutic insights
2015
Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs
Phinney DG, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix CM, Stolz DB, Watkins SC, Di YP, Leikauf GD, Kolls J, Riches DW, Deiuliis G, Kaminski N, Boregowda SV, McKenna DH, Ortiz LA. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nature Communications 2015, 6: 8472. PMID: 26442449, PMCID: PMC4598952, DOI: 10.1038/ncomms9472.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArrestinsBlotting, WesternCell-Derived MicroparticlesExosomesExtracellular VesiclesFlow CytometryHumansMacrophagesMesenchymal Stem CellsMiceMicroRNAsMicroscopy, ElectronMitochondriaMitophagyMyeloid Differentiation Factor 88Oxidative StressReceptors, ImmunologicSignal TransductionSilicosisToll-Like Receptor 4Toll-Like Receptor 9Toll-Like ReceptorsConceptsMesenchymal stem cellsStem cellsDomain-containing protein 1Stem cell nicheHealthy mitochondrial functionHaematopoietic stem cellsCell nichePlasma membraneToll-like receptor signalingIntracellular oxidative stressMitochondrial functionExtracellular vesiclesMicro RNAsReceptor signalingProtein 1MitophagyMSC survivalMitochondriaOxidative stressMacrophage functionVesiclesCellsRecent studiesMacrophage activationMacrophages