2017
Application of “Omics” and Systems Biology to Sarcoidosis Research
Crouser ED, Fingerlin TE, Yang IV, Maier LA, Nana-Sinkam P, Collman RG, Kaminski N. Application of “Omics” and Systems Biology to Sarcoidosis Research. Annals Of The American Thoracic Society 2017, 14: s445-s451. PMID: 29053026, PMCID: PMC5822413, DOI: 10.1513/annalsats.201707-567ot.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBiomedical ResearchDisease Models, AnimalEpigenomicsHumansMetabolomicsMicrobiotaProteomicsSarcoidosisSystems BiologyConceptsSystems biology researchBiology researchSystems biologyDistinct genetic mechanismsNumerous genetic mutationsField of sarcoidosisGenetic mechanismsDiverse clinical phenotypesOmicsMechanistic underpinningsComprehensive profilingPolygenic diseaseGenetic mutationsDiverse diseasesBiologyAdvanced computational approachesEnormous data setsComputational approachClinical phenotypeOrganismsPolygenicMutationsDisease-related mortalityPhenotypeLife-altering symptoms
2014
Open-Access Biorepository for Idiopathic Pulmonary Fibrosis. The Way Forward
White ES, Brown KK, Collard HR, Conoscenti CS, Cosgrove GP, Flaherty KR, Leff JA, Martinez FJ, Roman J, Rose D, Violette S, Kaminski N. Open-Access Biorepository for Idiopathic Pulmonary Fibrosis. The Way Forward. Annals Of The American Thoracic Society 2014, 11: 1171-1175. PMID: 25167209, PMCID: PMC4299004, DOI: 10.1513/annalsats.201406-289oi.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchHumansIdiopathic Pulmonary FibrosisInformaticsSpecimen HandlingTissue BanksConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisInvestigator-initiated clinical studyHuman lung diseasesHuman lung tissuePatient-derived samplesLung diseaseLung tissueClinical dataClinical studiesClinical phenotypingOutcome dataLung samplesAnimal modelingStandardized fashionHuman specimensTranslational researchPulmonary researchFibrosisBiorepositoryFuture studiesInvestigational processHuman physiologyCurrent knowledge gapsDifferent studiesFuture Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report
Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O’Riordan T, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 214-222. PMID: 24160862, PMCID: PMC3983890, DOI: 10.1164/rccm.201306-1141ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIdiopathic pulmonary fibrosisAlveolar epithelial injuryEffective medical therapyRole of inflammationTime of diagnosisPatient advocacy groupsMedian survivalMedical therapyEpithelial injuryPulmonary fibrosisPulmonary fibrosis researchIPF therapyIPF researchPreclinical modelingDrug AdministrationPatient communityU.S. FoodNHLBITranslation of discoveriesClinical researchersPatientsFibrosis researchTherapyDiseaseAberrant repair
2010
Strategic Plan for Lung Vascular Research
Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Strategic Plan for Lung Vascular Research. American Journal Of Respiratory And Critical Care Medicine 2010, 182: 1554-1562. PMID: 20833821, PMCID: PMC3029941, DOI: 10.1164/rccm.201006-0869ws.Peer-Reviewed Original ResearchConceptsPulmonary hypertensive diseasesSystemic vascular functionRight heart functionPulmonary vascular diseaseTranslational researchDisease-modifying therapiesCare of patientsHypertensive diseaseBlood InstituteLung diseaseVascular functionLung circulationLung vasculatureNational HeartVascular diseaseClinical studiesHeart functionTranslational findingsMultidisciplinary expertsDiseaseBiologic relationshipVascular biologyExtramural research programsVascular researchRegulatory signaling
2008
Alignment and classification of time series gene expression in clinical studies
Lin TH, Kaminski N, Bar-Joseph Z. Alignment and classification of time series gene expression in clinical studies. Bioinformatics 2008, 24: i147-i155. PMID: 18586707, PMCID: PMC2718630, DOI: 10.1093/bioinformatics/btn152.Peer-Reviewed Original Research