2014
Matrix Metalloproteinase-19 Promotes Metastatic Behavior In Vitro and Is Associated with Increased Mortality in Non–Small Cell Lung Cancer
Yu G, Herazo-Maya JD, Nukui T, Romkes M, Parwani A, Juan-Guardela BM, Robertson J, Gauldie J, Siegfried JM, Kaminski N, Kass DJ. Matrix Metalloproteinase-19 Promotes Metastatic Behavior In Vitro and Is Associated with Increased Mortality in Non–Small Cell Lung Cancer. American Journal Of Respiratory And Critical Care Medicine 2014, 190: 780-790. PMID: 25250855, PMCID: PMC4299607, DOI: 10.1164/rccm.201310-1903oc.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCell lung cancerLung cancerEpithelial-mesenchymal transitionLung tumorsMatrix metalloproteinasesProgression of NSCLCNormal lung tissuesHuman lung cancerNSCLC cell linesMultiple NSCLC cell linesLung cancer tumorsMMP19 expressionPoor prognosisCancer deathControl subjectsIncreased MortalityLung tissueNSCLC cellsMolecular pathogenesisPotential biomarkersDisease severityMetastatic behaviorCancerCancer tumors
2009
FACS-Assisted Microarray Profiling Implicates Novel Genes and Pathways in Zebrafish Gastrointestinal Tract Development
Stuckenholz C, Lu L, Thakur P, Kaminski N, Bahary N. FACS-Assisted Microarray Profiling Implicates Novel Genes and Pathways in Zebrafish Gastrointestinal Tract Development. Gastroenterology 2009, 137: 1321-1332. PMID: 19563808, PMCID: PMC2785077, DOI: 10.1053/j.gastro.2009.06.050.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell SeparationChromosomes, Human, Pair 8Digestive System NeoplasmsFlow CytometryGastrointestinal TractGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Expression Regulation, NeoplasticGene Regulatory NetworksGreen Fluorescent ProteinsHumansIn Situ HybridizationLarvaMicroRNAsOligonucleotide Array Sequence AnalysisOrganogenesisReproducibility of ResultsTime FactorsZebrafishZebrafish ProteinsConceptsFluorescence-activated cell sortingNovel genesGreen fluorescent proteinGene networksPutative transcription factorTransgenic zebrafish lineZebrafish Danio rerioPhosphatidylinositol-3-kinase (PI3K) pathwayExcellent model systemDevelopmental time pointsChromosome arm 8qGastrointestinal developmentZebrafish lineHuman orthologDanio rerioTranscription factorsKinase pathwayMicroarray profilingFluorescent proteinGFP expressionGenesNovel pathwayGFP cellsCell sortingOrganogenesis
2004
Gene Expression Patterns, Prognostic and Diagnostic Markers, and Lung Cancer Biology
Kaminski N, Krupsky M. Gene Expression Patterns, Prognostic and Diagnostic Markers, and Lung Cancer Biology. CHEST Journal 2004, 125: 111s-115s. PMID: 15136452, DOI: 10.1378/chest.125.5_suppl.111s-a.Peer-Reviewed Original ResearchBiomarkers, TumorForecastingGene Expression Regulation, NeoplasticHumansLung NeoplasmsOligonucleotide Array Sequence AnalysisPrognosis
2003
Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines
Margalit O, Eisenbach L, Amariglio N, Kaminski N, Harmelin A, Pfeffer R, Shohat M, Rechavi G, Berger R. Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. British Journal Of Cancer 2003, 89: 314-319. PMID: 12865923, PMCID: PMC2394268, DOI: 10.1038/sj.bjc.6600977.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Lewis LungCarrier ProteinsCCN Intercellular Signaling ProteinsFemaleGene Expression Regulation, NeoplasticGrowth SubstancesHumansIntracellular Signaling Peptides and ProteinsLung NeoplasmsMaleMelanomaMiceMice, Inbred C57BLNeoplasm MetastasisOligonucleotide Array Sequence AnalysisOncogene ProteinsPlasminogen Activator Inhibitor 2Polymerase Chain ReactionProto-Oncogene ProteinsTumor Cells, CulturedUteroglobinConceptsPlasminogen activator inhibitor-2Melanoma cell linesBrain natriuretic peptidePulmonary metastasesSet of genesLewis lung carcinomaWISP-1Cell linesSurfactant protein CMetastatic processReal-time quantitative PCRLung carcinomaOligonucleotide microarraysMicroarray analysisInhibitor 2GenesGenetic determinantsSpontaneous pulmonary metastasesIL-1 alphaMinimal residual diseaseProtein 1Cause of deathDevelopment of metastasesInterleukin-1 alphaQuantitative PCR
2001
DNA microarrays identification of primary and secondary target genes regulated by p53
Kannan K, Amariglio N, Rechavi G, Jakob-Hirsch J, Kela I, Kaminski N, Getz G, Domany E, Givol D. DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 2001, 20: 2225-2234. PMID: 11402317, DOI: 10.1038/sj.onc.1204319.Peer-Reviewed Original ResearchConceptsSecondary target genesTarget genesCell linesTumor suppressor p53Primary targetP53 activatesPresence of cycloheximideSuch genesTranscriptional programsTranscriptional changesAdditional genesDNA repairAbsence of cycloheximideMurine p53Primary genesOligonucleotide microarraysCell cycleSuppressor p53GenesProtein synthesisCell adhesionLung cancer cell linesCancer cell linesCell phenotypeHuman lung cancer cell lines