Characterization and peripheral blood biomarker assessment of anti–Jo‐1 antibody–positive interstitial lung disease
Richards TJ, Eggebeen A, Gibson K, Yousem S, Fuhrman C, Gochuico BR, Fertig N, Oddis CV, Kaminski N, Rosas IO, Ascherman DP. Characterization and peripheral blood biomarker assessment of anti–Jo‐1 antibody–positive interstitial lung disease. Arthritis & Rheumatism 2009, 60: 2183-2192. PMID: 19565490, PMCID: PMC2710404, DOI: 10.1002/art.24631.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseMultiplex enzyme-linked immunosorbent assayUsual interstitial pneumoniaC-reactive proteinAntibody-positive individualsEnzyme-linked immunosorbent assayInterstitial pneumoniaSerum levelsLung diseaseLarge cohortBiomarker assessmentIncidence of ILDMyositis-associated interstitial lung diseaseAnti-Jo-1 antibodyPulmonary function test resultsOpen lung biopsyNonspecific interstitial pneumoniaSerum inflammation markersSubset of patientsElevated serum levelsFunction test resultsIdiopathic pulmonary fibrosisDifferent patient subgroupsComputed tomography scanInducible chemokines CXCL9