2023
Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling.
Yanagihara T, Tsubouchi K, Zhou Q, Chong M, Otsubo K, Isshiki T, Schupp J, Sato S, Scallan C, Upagupta C, Revill S, Ayoub A, Chong S, Dvorkin-Gheva A, Kaminski N, Tikkanen J, Keshavjee S, Paré G, Guignabert C, Ask K, Kolb M. Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 1498-1514. PMID: 36917778, DOI: 10.1164/rccm.202109-2174oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisVascular smooth muscle cellsAdvanced idiopathic pulmonary fibrosisPulmonary hypertensionFibrotic lungsVascular remodelingEndothelial cellsPulmonary fibrosisLung diseaseLung fibrosisDevelopment of PHConcomitant pulmonary hypertensionProgressive lung scarringPulmonary vascular remodelingFibrotic lung diseaseProgression of fibrosisActivation of VSMCsActive TGF-β1Fatal lung diseaseSmooth muscle cellsWhole-exome sequencingLung scarringEndothelial dysfunctionPoor prognosisFibrogenic effects
2018
S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension
Tzouvelekis A, Herazo‐Maya J, Ryu C, Chu J, Zhang Y, Gibson KF, Adonteng‐Boateng P, Li Q, Pan H, Cherry B, Ahmad F, Ford HJ, Herzog EL, Kaminski N, Fares WH. S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension. Respirology 2018, 23: 771-779. PMID: 29611244, PMCID: PMC6047907, DOI: 10.1111/resp.13302.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsPH patientsPH cohortCardiac outputWorld Health Organization group 1Idiopathic pulmonary fibrosis patientsPulmonary hypertension patientsPulmonary fibrosis patientsBlood mononuclear cellsProtein serum concentrationsHigher S100A12Pulmonary hypertensionS100A12 levelsOverall mortalityHypertension patientsPrognostic valueValidation cohortMononuclear cellsPeripheral bloodSerum concentrationsInflammatory diseasesGroup 1PatientsFibrosis patientsS100A12
2016
Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension
Fares W, Pandit K, Kaminski N. Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension. 2016, 123-133. DOI: 10.1007/978-3-319-23594-3_7.Peer-Reviewed Original ResearchPulmonary arterial hypertensionSmall non-coding RNAsNon-coding RNAsRole of microRNAsNumerous genesNetwork biologyGene expressionPhysiological processesVascular remodeling diseaseArtery smooth muscle cellsPulmonary artery smooth muscle cellsProgression of PAHMicroRNA signallingNovel mechanismMicroRNAsSmooth muscle cellsRight heart failureMuscle cellsArterial hypertensionPulmonary hypertensionHeart failureEndothelial cellsArterial remodelingHistological changesTherapeutic strategies
2010
Characterization of Microrna Expression Profile In Platelets In Sickle Cell Disease
Jain S, Raghavachari N, Woodhouse K, Kaminski N, Gladwin M. Characterization of Microrna Expression Profile In Platelets In Sickle Cell Disease. Blood 2010, 116: 2030. DOI: 10.1182/blood.v116.21.2030.2030.Peer-Reviewed Original ResearchSickle cell diseasePulmonary hypertensionSCD patientsPathological platelet activationPlatelet activationCell diseaseRace-matched healthy controlsSickle cell disease patientsAfrican American control subjectsPittsburgh Medical CenterPlatelet-rich plasma samplesP-valueThromboembolic complicationsStudy enrollmentBlood InstitutePresent studyControl subjectsDisease patientsNational HeartIntravascular hemolysisHealthy controlsSCD groupSCD pathogenesisReal-time PCRIndividual patientsGenomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
Rajkumar R, Konishi K, Richards TJ, Ishizawar DC, Wiechert AC, Kaminski N, Ahmad F. Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension. AJP Heart And Circulatory Physiology 2010, 298: h1235-h1248. PMID: 20081107, PMCID: PMC2853417, DOI: 10.1152/ajpheart.00254.2009.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionIdiopathic pulmonary fibrosisPathogenesis of PAHIdiopathic pulmonary arterial hypertensionPulmonary hypertensionArterial hypertensionRegulation of actinThrombospondin type 1 motif 9Pulmonary arteriolar remodelingSecondary pulmonary hypertensionCoagulation factor II receptorDistinct pathophysiological mechanismsLife-threatening conditionDistinct gene expression signaturesEstrogen receptor 1Nuclear receptor coactivator 2RNA expression profilesPurinergic receptor P2YGenomewide microarray analysisPlatelet factor 4RNA expression profilingHigh expression levelsOncogene homolog 1Gene expression signaturesProtein ubiquitination
2008
Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs
Wu W, Dave NB, Yu G, Strollo PJ, Kovkarova-Naumovski E, Ryter SW, Reeves SR, Dayyat E, Wang Y, Choi AM, Gozal D, Kaminski N. Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs. Physiological Genomics 2008, 36: 24-34. PMID: 18826996, PMCID: PMC2604785, DOI: 10.1152/physiolgenomics.00258.2007.Peer-Reviewed Original ResearchConceptsSystems biology approachEstrogen receptor 1Lung responseQuantitative real-time PCRRat lungBiology approachIntermittent hypoxiaExpression patternsSustained hypoxiaReal-time PCRDistinct gene expression patternsDifferent temporal expression patternsDownstream physiological effectsGene expression patternsTemporal expression patternsSteroid hormone receptor activityGene expression profilesTemporal expression changesRegulatory networksHormone receptor activityPulmonary hypertensionKey proteinsGene expressionMolecular networksExpression changes
2005
Abnormal Vascular Phenotypes in Patients With Idiopathic Pulmonary Fibrosis and Secondary Pulmonary Hypertension
Gagermeier J, Dauber J, Yousem S, Gibson K, Kaminski N. Abnormal Vascular Phenotypes in Patients With Idiopathic Pulmonary Fibrosis and Secondary Pulmonary Hypertension. CHEST Journal 2005, 128: 601s. PMID: 16373857, DOI: 10.1378/chest.128.6_suppl.601s.Peer-Reviewed Original Research