2009
Chronic lung diseases
Wu W, Kaminski N. Chronic lung diseases. WIREs Mechanisms Of Disease 2009, 1: 298-308. PMID: 20835999, DOI: 10.1002/wsbm.23.Peer-Reviewed Original ResearchConceptsSystems biology approachBiology approachChronic lung diseaseComplex human diseasesHigh-throughput technologiesLung diseaseSystems biologyHuman diseasesTraditional experimental approachesComplex lung diseaseBiomedical researchExperimental approachSerious economic burdenHigh morbiditySerious threatHuman healthEconomic burdenMortality rateDiseaseBiologyMicroarrayPromising findings
2006
Gene Expression Profiling as a Window into Idiopathic Pulmonary Fibrosis Pathogenesis
Kaminski N, Rosas IO. Gene Expression Profiling as a Window into Idiopathic Pulmonary Fibrosis Pathogenesis. Annals Of The American Thoracic Society 2006, 3: 339-344. PMID: 16738198, PMCID: PMC2658685, DOI: 10.1513/pats.200601-011tk.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisModel of IPFIdiopathic pulmonary fibrosis (IPF) pathogenesisPulmonary fibrosis pathogenesisMinority of investigatorsPulmonary fibrosisFibrosis pathogenesisGene expression profilingMultiple diseasesExpression microarraysExpression profilingGene expressionMicroarrayIntegrative systems approach
2005
Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis
Selman M, Pardo A, Barrera L, Estrada A, Watson SR, Wilson K, Aziz N, Kaminski N, Zlotnik A. Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis. American Journal Of Respiratory And Critical Care Medicine 2005, 173: 188-198. PMID: 16166619, PMCID: PMC2662988, DOI: 10.1164/rccm.200504-644oc.Peer-Reviewed Original ResearchConceptsGene expression signaturesExpression signaturesCustom oligonucleotide microarrayGene expression patternsOligonucleotide DNA microarrayStandard Affymetrix protocolGene clusterDNA microarraysExpression patternsGene expressionOligonucleotide microarraysComplementary ribonucleic acidTranscriptional signatureProbe setsCustom arrayT cell activationTissue remodelingNonspecific interstitial pneumoniaRibonucleic acidGenesMicroarrayInterstitial lung diseaseHypersensitivity pneumonitisPathogenic mechanismsExpressionFrom signatures to models: understanding cancer using microarrays
Segal E, Friedman N, Kaminski N, Regev A, Koller D. From signatures to models: understanding cancer using microarrays. Nature Genetics 2005, 37: s38-s45. PMID: 15920529, DOI: 10.1038/ng1561.Peer-Reviewed Original ResearchConceptsTranscriptional networksModel organismsRegulatory mechanismsBiological processesMolecular underpinningsMechanistic understandingModular organizationDisease mechanismsComputational analysisComprehensive viewGenomicsRobust signatureOrganismsMicroarrayComparative analysisMechanismSignaturesCellsCancerManagement of cancer