2022
Metagenomic sequencing of the bronchoalveolar lavage extracellular virome and cellular transcriptome of sarcoidosis patients does not detect rubella virus
Keeler E, Vukmirovic M, Yan X, Gulino K, Ghedin E, Kaminski N, Sullivan K, Bushman F, Collman R, Rosenbach M. Metagenomic sequencing of the bronchoalveolar lavage extracellular virome and cellular transcriptome of sarcoidosis patients does not detect rubella virus. Sarcoidosis, Vasculitis, And Diffuse Lung Diseases 2022, 39: e2022040. PMID: 36533601, PMCID: PMC9798337, DOI: 10.36141/svdld.v39i4.13407.Peer-Reviewed Original ResearchSarcoidosis patientsRubella virusBronchoalveolar lavageMultisystem granulomatous inflammatory diseaseImmune-competent patientsRubella virus infectionGranulomatous inflammatory diseaseCutaneous sarcoidosisAntigenic triggerBAL cellsUnclear etiologyRubella virus genomeInflammatory diseasesCutaneous granulomasGranulomatous lesionsVirus infectionVirus gene expressionLung samplesAcellular fluidCompetent patientsPatientsSarcoidosisOverlapping featuresMetagenomic sequencingVirus
2021
Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis
Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y. Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis. European Respiratory Journal 2021, 58: 2003397. PMID: 34049947, DOI: 10.1183/13993003.03397-2020.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisAnti-fibrotic propertiesRole of fibroblastsFibroblastic fociPathogenesis of IPFLung fibrosis modelSenescence-associated secretory phenotypeNormal lung samplesMesenchymal stromal cellsIPF patientsIPF lungsDense fibrosisPathological hallmark lesionsFibrosis modelFibrotic lungsHallmark lesionsSingle-cell atlasActive fibrogenesisElderly individualsLung samplesFibrosisSingle-cell RNA sequencingFibrotic regionsSecretory phenotype
2014
Open-Access Biorepository for Idiopathic Pulmonary Fibrosis. The Way Forward
White ES, Brown KK, Collard HR, Conoscenti CS, Cosgrove GP, Flaherty KR, Leff JA, Martinez FJ, Roman J, Rose D, Violette S, Kaminski N. Open-Access Biorepository for Idiopathic Pulmonary Fibrosis. The Way Forward. Annals Of The American Thoracic Society 2014, 11: 1171-1175. PMID: 25167209, PMCID: PMC4299004, DOI: 10.1513/annalsats.201406-289oi.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisInvestigator-initiated clinical studyHuman lung diseasesHuman lung tissuePatient-derived samplesLung diseaseLung tissueClinical dataClinical studiesClinical phenotypingOutcome dataLung samplesAnimal modelingStandardized fashionHuman specimensTranslational researchPulmonary researchFibrosisBiorepositoryFuture studiesInvestigational processHuman physiologyCurrent knowledge gapsDifferent studies