2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original Research
2023
Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Korem N, Ben-Zion Z, Spiller T, Duek O, Harpaz-Rotem I, Pietrzak R. Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 339: 89-97. PMID: 37437721, DOI: 10.1016/j.jad.2023.07.036.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAvoidance copingTraumatic eventsU.S. military veteransEmotional stabilityNegative affect symptomsEmotional neglectSexual abuseAffect symptomsMilitary veteransAvoidant coping strategiesGreater emotional stabilityPhysical health outcomesPsychosocial risk factorsConsolidated memoryStress disorderCoping strategiesAdverse childhood experiencesStressful experiencesCopingVeterans StudyChildhood experiencesStrong feelingsNetwork analytic approachConscientiousnessLong term structural and functional neural changes following a single infusion of Ketamine in PTSD
Duek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.Peer-Reviewed Original ResearchConceptsKetamine recipientsSingle infusionMain study outcomeTiming of administrationEnd of treatmentNMDA receptor antagonistFunctional neural changesFrequency of administrationSignificant clinical implicationsTrauma-focused psychotherapyBrief exposure therapyAmygdala-vmPFC connectivityPost-retrieval extinctionKetamine doseKetamine administrationReceptor antagonistTrauma scriptsNeural changesClinical implicationsDecreased connectivityExposure therapyKetamineTrauma memoriesStudy outcomesUncinate fasciculus
2022
Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors
Ben-Zion Z, Korem N, Spiller TR, Duek O, Keynan JN, Admon R, Harpaz-Rotem I, Liberzon I, Shalev AY, Hendler T. Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors. Molecular Psychiatry 2022, 28: 657-667. PMID: 36280750, PMCID: PMC9918676, DOI: 10.1038/s41380-022-01842-x.Peer-Reviewed Original ResearchConceptsEmergency departmentAmygdala subregionsPTSD diagnosisGeneral hospital emergency departmentLeft amygdala volumeHospital emergency departmentRight hippocampus volumeCA1 hippocampal subregionRecent trauma survivorsTrauma survivorsCivilian trauma survivorsED admissionEligible participantsHippocampus volumeAmygdala volumeHippocampal subregionsVulnerability traitsDisorder pathogenesisClinical InterviewModerate evidenceHippocampus subregionsTrauma exposureStructural MRIRobust evidenceLower initial volumeDelirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study
Spiller TR, Tufan E, Petry H, Böttger S, Fuchs S, Duek O, Ben-Zion Z, Korem N, Harpaz-Rotem I, von Känel R, Ernst J. Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study. Journal Of Psychiatric Research 2022, 156: 194-199. PMID: 36252349, DOI: 10.1016/j.jpsychires.2022.10.018.Peer-Reviewed Original ResearchConceptsDelirium Observation ScaleAcute care settingNursing dataCare settingsSingle tertiary teaching hospitalPatients 18 yearsTertiary teaching hospitalDelirium prediction modelSuch screening programsDelirium screeningAcute careMean ageTeaching hospitalInclusion criteriaScreening programDeliriumPatientsClinical practiceTotal scoreDemographic characteristicsCharacteristic curveScreening procedureModel development studiesRiskAdditional measuresEmotional numbing in PTSD is associated with lower amygdala reactivity to pain
Korem N, Duek O, Ben-Zion Z, Kaczkurkin AN, Lissek S, Orederu T, Schiller D, Harpaz-Rotem I, Levy I. Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology 2022, 47: 1913-1921. PMID: 35945274, PMCID: PMC9485255, DOI: 10.1038/s41386-022-01405-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAmygdala reactivityLower amygdala reactivityHigher pain responseLower amygdala activationAltered pain perceptionAmygdala activationProcessing of painAmygdala responseEmotional numbingPain correlateMild painPain processingPain thresholdPain responsePain perceptionPainControl groupPTSD groupStress disorderRobust reductionAmygdala activityCombat controlsAmygdalaEmotional numbing symptomsThe link between math anxiety and performance does not depend on working memory: A network analysis study
Korem N, Cohen L, Rubinsten O. The link between math anxiety and performance does not depend on working memory: A network analysis study. Consciousness And Cognition 2022, 100: 103298. PMID: 35217396, DOI: 10.1016/j.concog.2022.103298.Peer-Reviewed Original Research
2020
Frequency-based Dissociation of Symbolic and Nonsymbolic Numerical Processing during Numerical Comparison
Rubinsten O, Korem N, Levin N, Furman T. Frequency-based Dissociation of Symbolic and Nonsymbolic Numerical Processing during Numerical Comparison. Journal Of Cognitive Neuroscience 2020, 32: 762-782. PMID: 32083518, DOI: 10.1162/jocn_a_01550.Peer-Reviewed Original ResearchDifferent neural activations for an approaching friend versus stranger: Linking personal space to numerical cognition
Rubinsten O, Korem N, Perry A, Goldberg M, Shamay‐Tsoory S. Different neural activations for an approaching friend versus stranger: Linking personal space to numerical cognition. Brain And Behavior 2020, 10: e01613. PMID: 32342617, PMCID: PMC7303380, DOI: 10.1002/brb3.1613.Peer-Reviewed Original ResearchConceptsDevelopmental dyscalculiaEvent-related potential studyDifferent neural activationsPersonal spacePreferred distanceSpatial attentionNumerical cognitionHuman spatial behaviorSocial perceptionSpatial cognitionFriend conditionSpatial skillsNeural activationComputerized versionInterpersonal distanceControl participantsNeurocognitive conditionsNeurocognitive deficienciesPotential studiesSpatial knowledgeN1 wavePersonal distanceDistance taskUniversity studentsCognition
2017
Is susceptibility to cross-language interference domain specific?
Prior A, Degani T, Awawdy S, Yassin R, Korem N. Is susceptibility to cross-language interference domain specific? Cognition 2017, 165: 10-25. PMID: 28458090, DOI: 10.1016/j.cognition.2017.04.006.Peer-Reviewed Original ResearchConceptsExecutive functionL1 interferenceLexical interferenceL2 proficiencySyntactic interferenceSemantic similarity judgment taskSelf-paced reading paradigmSecond language achievementDifferent-script bilingualsGeneral executive functionsNumerical Stroop taskSimilarity judgment taskCross-language interferenceGeneral EF abilityBilingual university studentsEF abilitiesStroop taskJudgment taskL2 processingOrthographic systemBilingual languageLanguage achievementReading paradigmLanguage domainsHebrew sentences
2016
The role of empathy in the neural responses to observed human social touch
Peled-Avron L, Levy-Gigi E, Richter-Levin G, Korem N, Shamay-Tsoory S. The role of empathy in the neural responses to observed human social touch. Cognitive, Affective, & Behavioral Neuroscience 2016, 16: 802-813. PMID: 27165338, DOI: 10.3758/s13415-016-0432-5.Peer-Reviewed Original ResearchConceptsHuman social touchNeural responsesSocial touchEmpathic traitsEmpathic participantsElectrophysiological responsesMore pleasant emotionsRole of empathyGreater mu suppressionLevel of empathyPleasant emotionsSensorimotor resonanceEmotional contagionMu suppressionPersonal distressObserved touchNeural markersTactile stimuliInanimate objectsElectroencephalography (EEG) activityInterindividual differencesEmotionsHuman interactionEmpathyParticipants
2015
Targeting the endocannabinoid system to treat anxiety-related disorders
Korem N, Zer-Aviv T, Ganon-Elazar E, Abush H, Akirav I. Targeting the endocannabinoid system to treat anxiety-related disorders. Journal Of Basic And Clinical Physiology And Pharmacology 2015, 27: 193-202. PMID: 26426887, DOI: 10.1515/jbcpp-2015-0058.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-traumatic stress disorderEndocannabinoid systemAnxiety-related disordersCommon self-reported reasonsAdministration of cannabinoidsEncouraging preclinical dataEffects of cannabinoidsAnxiety-like behaviorExogenous cannabinoidsPreclinical dataSelf-reported reasonsChronic usageUntoward effectsAnxiogenic effectsMouse modelPsychiatric disordersAnimal modelsPTSD patientsClinical settingPreclinical researchStress disorderAnxiety disordersCannabinoidsDisordersControl of emotions