2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original Research
2023
Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Korem N, Ben-Zion Z, Spiller T, Duek O, Harpaz-Rotem I, Pietrzak R. Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 339: 89-97. PMID: 37437721, DOI: 10.1016/j.jad.2023.07.036.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalEmotionsHumansRisk FactorsStress Disorders, Post-TraumaticVeteransConceptsPosttraumatic stress disorderAvoidance copingTraumatic eventsU.S. military veteransEmotional stabilityNegative affect symptomsEmotional neglectSexual abuseAffect symptomsMilitary veteransAvoidant coping strategiesGreater emotional stabilityPhysical health outcomesPsychosocial risk factorsConsolidated memoryStress disorderCoping strategiesAdverse childhood experiencesStressful experiencesCopingVeterans StudyChildhood experiencesStrong feelingsNetwork analytic approachConscientiousness
2022
Emotional numbing in PTSD is associated with lower amygdala reactivity to pain
Korem N, Duek O, Ben-Zion Z, Kaczkurkin AN, Lissek S, Orederu T, Schiller D, Harpaz-Rotem I, Levy I. Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology 2022, 47: 1913-1921. PMID: 35945274, PMCID: PMC9485255, DOI: 10.1038/s41386-022-01405-2.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaEmotionsHumansMagnetic Resonance ImagingPainStress Disorders, Post-TraumaticVeteransConceptsPosttraumatic stress disorderAmygdala reactivityLower amygdala reactivityHigher pain responseLower amygdala activationAltered pain perceptionAmygdala activationProcessing of painAmygdala responseEmotional numbingPain correlateMild painPain processingPain thresholdPain responsePain perceptionPainControl groupPTSD groupStress disorderRobust reductionAmygdala activityCombat controlsAmygdalaEmotional numbing symptoms
2018
Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity
Segev A, Korem N, Mizrachi Zer-Aviv T, Abush H, Lange R, Sauber G, Hillard C, Akirav I. Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity. Neuropsychopharmacology 2018, 43: 2017-2027. PMID: 29977073, PMCID: PMC6098035, DOI: 10.1038/s41386-018-0135-4.Peer-Reviewed Original ResearchConceptsLong-term potentiationPosttraumatic stress disorderBasolateral amygdalaSituational remindersEmotional memoryFatty acid amide hydrolase inhibitor URB597Fear responsesCB1 receptor antagonist AM251Effects of URB597Receptor antagonist AM251Role of endocannabinoidsDevelopment of PTSDHippocampal CA1 areaTrauma-related cuesEndogenous cannabinoid levelsSevere footshockAntagonist AM251Endocannabinoid contentAEA levelsCA1 areaEffects of exposureRisk factorsFAAH activityTreatment responseFAAH inhibition
2014
Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
Korem N, Akirav I. Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing. Neuropsychopharmacology 2014, 39: 2709-2722. PMID: 24897957, PMCID: PMC4200492, DOI: 10.1038/npp.2014.132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoxazinesBrainCannabinoid Receptor AgonistsCannabinoidsCuesDisease Models, AnimalElectroshockEmotionsExtinction, PsychologicalLong-Term PotentiationMaleMorpholinesNaphthalenesNeuronal PlasticityRats, Sprague-DawleyReceptors, CannabinoidReceptors, GlucocorticoidReflex, StartleSpace PerceptionStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderSituational remindersEmotional processingPrefrontal cortexTrauma exposureTraumatic eventsBasolateral amygdalaPTSD-like symptomsTrajectory of PTSDCB1/2 receptor agonistCB1 receptorsGlucocorticoid receptorImpaired extinctionSingle footshockStress disorderBrain areasFootshockCB1R expressionImpaired plasticityReceptor agonistDay 1Day 3ProcessingCA1Altered expression