2022
Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee JM, Kloss F, Bittner S, Nitsch R, Zipp F, Vogt J. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Science Translational Medicine 2022, 14: eabk0135. PMID: 35442704, DOI: 10.1126/scitranslmed.abk0135.Peer-Reviewed Original ResearchConceptsStroke outcomeExperimental strokeGlutamatergic transmissionCortical excitabilityATX concentrationsAstrocyte-specific deletionDifferent time pointsStroke eventsPerisynaptic processesExcess glutamateTherapeutic approachesAnimal modelsTransgenic miceEnzyme autotaxinLPA signalingATX inhibitionPharmacological inhibitionStrokeTranslational potentialTime pointsSingle nucleotide polymorphismsAutotaxinOutcomesExcitabilityInhibition
2019
Gray matter integrity predicts white matter network reorganization in multiple sclerosis
Radetz A, Koirala N, Krämer J, Johnen A, Fleischer V, Gonzalez‐Escamilla G, Cerina M, Muthuraman M, Meuth S, Groppa S. Gray matter integrity predicts white matter network reorganization in multiple sclerosis. Human Brain Mapping 2019, 41: 917-927. PMID: 32026599, PMCID: PMC7268008, DOI: 10.1002/hbm.24849.Peer-Reviewed Original ResearchConceptsDeep gray matter volumesGray matter volumeMultiple sclerosisGray matter integrityMatter volumeWhite matter networksEarly relapsing-remitting multiple sclerosisRelapsing-remitting multiple sclerosisTime pointsGray matter atrophyDeep gray matter structuresCognitive performanceMiddle temporal cortexGray matter structuresGray matter regionsDisability progressionBrain stemMatter damageSignificant atrophyMatter atrophyDeep gray matter regionsCortical thicknessTemporal cortexTissue damageAtrophy
2015
Testing the effects of pre-processing on voxel based morphometry analysis
Chaitanya C, Koirala N, Mideksa K, Anwar A, Schmidt G, Deuschl G, Groppa S, Muthuraman M. Testing the effects of pre-processing on voxel based morphometry analysis. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2015, 2015: 4302-4305. PMID: 26737246, DOI: 10.1109/embc.2015.7319346.Peer-Reviewed Original ResearchConceptsGray matter volumeGray matter differencesDifferent time pointsTime pointsMagnetic resonance imagesBotulinum toxin injectionEvidence-based therapiesStructural grey matter differencesVoxel-wise comparisonBase therapyToxin injectionCross-sectional data analysisBotulinum toxinMatter volumeRespective musclesMorphometry analysisLongitudinal data analysisPatientsLongitudinal analysisResonance imagesInjectionBrainTreatmentSecond aimStatistical analysis