2020
Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease
Muthuraman M, Bange M, Koirala N, Ciolac D, Pintea B, Glaser M, Tinkhauser G, Brown P, Deuschl G, Groppa S. Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease. Brain 2020, 143: 3393-3407. PMID: 33150359, PMCID: PMC7116448, DOI: 10.1093/brain/awaa297.Peer-Reviewed Original ResearchConceptsDeep brain stimulationBrain stimulationParkinson's diseaseStimulation frequencyCross-frequency couplingMotor symptomsSubthalamic nucleusGamma oscillationsDeep Brain Stimulation FrequencyOscillatory activityPhysiological neural activityMotor function recoveryEffective deep brain stimulationHigh-frequency stimulationPathological oscillatory activityCross-frequency interactionsCortico-subcortical networksDifferent oscillatory activitiesSymptom controlParietal cortex regionsClinical effectsFunction recoverySymptom alleviationMotor impairmentSubcortical regions
2018
Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease
Muthuraman M, Koirala N, Ciolac D, Pintea B, Glaser M, Groppa S, Tamás G, Groppa S. Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease. Frontiers In Neurology 2018, 9: 711. PMID: 30210436, PMCID: PMC6119713, DOI: 10.3389/fneur.2018.00711.Peer-Reviewed Original ResearchDeep brain stimulationL-dopa therapyParkinson's diseaseBrain stimulationEffects of DBSL-DOPAImpact of DBSNon-motor symptomsEffective treatment optionEvidence-based therapiesEffective pharmacological therapyCentral nervous systemBrain networksPerioperative algorithmSpecific brain networksDopaminergic medicationPharmacological therapyClinical effectsMotor symptomsPD patientsPharmacodynamic effectsPharmacological treatmentTherapy optionsTreatment optionsFirst complication