2022
Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease
Gonzalez-Escamilla G, Koirala N, Bange M, Glaser M, Pintea B, Dresel C, Deuschl G, Muthuraman M, Groppa S. Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease. Neurology And Therapy 2022, 11: 265-282. PMID: 35000133, PMCID: PMC8857357, DOI: 10.1007/s40120-021-00318-4.Peer-Reviewed Original ResearchSupplementary motor areaClinical outcomesParkinson's diseaseDBS locationPostoperative MRIBrain stimulationIntroductionDeep brain stimulationMotor symptom improvementPostoperative clinical outcomesIdiopathic PD patientsPrimary motor cortexOptimal clinical outcomesDeep brain stimulationSTN-DBS outcomesSuperior frontal cortexDBS electrode positionUse of MRIUse of DBSSubcortical volumetryDBS outcomesPD patientsSubcortical targetsSymptom improvementDBS surgeryMotor cortex
2016
Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;
Koirala N, Fleischer V, Granert O, Deuschl G, Muthuraman M, Groppa S. Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2016, 2016: 5533-5536. PMID: 28269510, DOI: 10.1109/embc.2016.7591980.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDeep brain stimulationSTN-DBSParkinson's diseaseDiffusion tensor imagingBrain stimulationProbabilistic tractographyActive DBS contactsPostoperative clinical outcomesPrimary motor cortexStandard therapeutic optionIdiopathic Parkinson's diseaseCortico-spinal tractSubcortical seedsClinical outcomesTherapeutic optionsDBS contactsMotor cortexDBS treatmentUniversity HospitalSubthalamic nucleusMotor areaPremotor regionsStimulation siteTensor imaging