Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease
Koirala N, Fleischer V, Glaser M, Zeuner K, Deuschl G, Volkmann J, Muthuraman M, Groppa S. Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease. Brain Topography 2017, 31: 311-321. PMID: 28986718, DOI: 10.1007/s10548-017-0597-4.Peer-Reviewed Original ResearchConceptsDeep brain stimulationDiffusion-weighted imagingPostoperative clinical outcomesClinical responseParkinson's diseaseSTN-DBSClinical outcomesSubthalamic nucleusBrain stimulationSubthalamic nucleus deep brain stimulationNon-motor symptomsOptimal clinical responseConnectivity profilesPre-intervention predictorsEvidence-based stateIndependent predictorsPD patientsTherapy optionsClinical effectivenessCingulate gyrusFrontal lobe connectivityCerebral regionsT MRI scannerCerebral networksPrefrontal cortex