Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis
Ciolac D, Luessi F, Gonzalez-Escamilla G, Koirala N, Riedel C, Fleischer V, Bittner S, Krämer J, Meuth S, Muthuraman M, Groppa S. Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis. Frontiers In Immunology 2019, 10: 1779. PMID: 31417557, PMCID: PMC6682686, DOI: 10.3389/fimmu.2019.01779.Peer-Reviewed Original ResearchConceptsCortical atrophyDisease activityMultiple sclerosisDMF groupDeep GM volumesDimethyl fumarate treatmentT-cell depletionDisease-modifying drugsWhite matter damageImmune cell dynamicsDMF therapyNAT patientsStrong CD8Lymphocyte subsetsDisease durationDisease courseMS patientsCell depletionMatter damageLess atrophyFumarate treatmentTreatment paradigmBrain network responsesLesion volumeTherapy response