Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis
Ciolac D, Luessi F, Gonzalez-Escamilla G, Koirala N, Riedel C, Fleischer V, Bittner S, Krämer J, Meuth S, Muthuraman M, Groppa S. Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis. Frontiers In Immunology 2019, 10: 1779. PMID: 31417557, PMCID: PMC6682686, DOI: 10.3389/fimmu.2019.01779.Peer-Reviewed Original ResearchConceptsCortical atrophyDisease activityMultiple sclerosisDMF groupDeep GM volumesDimethyl fumarate treatmentT-cell depletionDisease-modifying drugsWhite matter damageImmune cell dynamicsDMF therapyNAT patientsStrong CD8Lymphocyte subsetsDisease durationDisease courseMS patientsCell depletionMatter damageLess atrophyFumarate treatmentTreatment paradigmBrain network responsesLesion volumeTherapy responseLongitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis
Fleischer V, Koirala N, Droby A, Gracien R, Deichmann R, Ziemann U, Meuth S, Muthuraman M, Zipp F, Groppa S. Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis. Therapeutic Advances In Neurological Disorders 2019, 12: 1756286419838673. PMID: 31040880, PMCID: PMC6482642, DOI: 10.1177/1756286419838673.Peer-Reviewed Original ResearchRelapsing-remitting MSEarly relapsing-remitting MSHealthy controlsDisease activityEarly relapsing-remitting multiple sclerosisLongitudinal brain volume changesRelapsing-remitting multiple sclerosisCortical atrophy patternsStructural cortical networksPatients' disease activityNetwork reorganizationBrain volume changesClinical disease manifestationsDetectable atrophyMultiple sclerosisAtrophy patternsDisease manifestationsAtrophy measurementsCortical responsesGray matter networksBrain functionPatientsT MRICortical networksGraph theoretical analysis