Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth S, Groppa S. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal 2017, 25: 338-343. PMID: 29226779, DOI: 10.1177/1352458517748474.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCortical atrophyRelapsing-remitting multiple sclerosisBlood-brain barrier integrityLongitudinal magnetic resonance imagingCerebrospinal fluid markersGray matter pathologyHigher functional disabilityCerebrospinal fluid albuminQuotient of albuminMagnetic resonance imagingCumulative disabilityClinical disabilityWidespread atrophyFunctional disabilityCSF concentrationsCSF markersDisease progressionFunctional deteriorationImmunoglobulin AAtrophy measurementsFluid markersUnequivocal predictorsBarrier integrityDisease evolution