2024
Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis
Aldridge C, Armstrong N, Sunmonu N, Becker C, Palakshappa D, Lindgren A, Pedersen A, Stanne T, Jern C, Maguire J, Hsu F, Keene K, Sale M, Irvin M, Worrall B. Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis. Frontiers In Stroke 2024, 3: 1338636. DOI: 10.3389/fstro.2024.1338636.Peer-Reviewed Original ResearchPolygenic risk scoresAncestral groupsGenome-wide significant variantsGenome-wide association study meta-analysisGenetic riskRecurrent stroke riskGWAS modelsEffective allelesRisk of incident strokeGenetic lociAssociated with incident ischemic strokeRecurrent strokeStudy meta-analysisSignificant variantsStroke riskIncident ischemic strokeGenetic studiesBiological insightsEuropean ancestryGenetic associationGenesMYH11 geneBiological relevanceLong-term disabilityGWAS
2022
Abstract WMP107: Back To The Future: Recurrent Stroke Genome Wide Association Study
Aldridge C, Armstrong N, Sunmonu N, Hsu F, Keene K, Sale M, Worrall B. Abstract WMP107: Back To The Future: Recurrent Stroke Genome Wide Association Study. Stroke 2022, 53: awmp107-awmp107. DOI: 10.1161/str.53.suppl_1.wmp107.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsCadherin-8Novel single nucleotide polymorphismsBiallelic single nucleotide polymorphismsGenome wide association studiesGenetic Reference PanelTOPMed imputation serverRecurrent strokeImputation ServerIntergenic regionAssociation studiesChromosome 1Ancestry distributionReference panelImputation qualityCox proportional hazards modelsNucleotide polymorphismsPopulation ancestryGenotyped samplesTOPMedMixed ancestryProportional hazards modelPotential new insightsChromosomeGenes