2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal models
2014
Improved Modeling of In Vivo Kinetics of Slowly Diffusing Radiotracers for Tumor Imaging
Wilks M, Knowles S, Wu A, Huang S. Improved Modeling of In Vivo Kinetics of Slowly Diffusing Radiotracers for Tumor Imaging. Journal Of Nuclear Medicine 2014, 55: 1539-1544. PMID: 24994929, PMCID: PMC4334373, DOI: 10.2967/jnumed.114.140038.Peer-Reviewed Original Research
2013
Factors affecting tumor 18 F-FDG uptake in longitudinal mouse PET studies
Sha W, Ye H, Iwamoto K, Wong K, Wilks M, Stout D, McBride W, Huang S. Factors affecting tumor 18 F-FDG uptake in longitudinal mouse PET studies. EJNMMI Research 2013, 3: 51. PMID: 23841937, PMCID: PMC3718724, DOI: 10.1186/2191-219x-3-51.Peer-Reviewed Original ResearchF-FDG uptakeF-FDG positron emission tomographyF-FDGMDA-MB-231Positron emission tomographyEffect of blood glucose levelsTumor diameterBlood glucose levelsF-FDG PET scansSevere combined immunodeficient miceGlucose levelsTumor-bearing micePositron emission tomography imagingMultivariate regression analysisHeart time-activity curveTime-activity curvesTumor sizeImmunodeficient miceTumor-dependentTumor typesPET scansTumor growthPlasma curveTumorPatlak analysis