2011
Post‐epidemic eosinophilia–myalgia syndrome associated with L‐tryptophan
Allen JA, Peterson A, Sufit R, Hinchcliff ME, Mahoney JM, Wood TA, Miller FW, Whitfield ML, Varga J. Post‐epidemic eosinophilia–myalgia syndrome associated with L‐tryptophan. Arthritis & Rheumatism 2011, 63: 3633-3639. PMID: 21702023, PMCID: PMC3848710, DOI: 10.1002/art.30514.Peer-Reviewed Original ResearchConceptsEosinophilia-myalgia syndromeL-tryptophan-associated eosinophilia-myalgia syndromeNew casesL-tryptophanGrowth factor βChronic neuropathyPeripheral eosinophiliaSubacute onsetLesional skinSkin indurationImmunogenetic featuresInterleukin-4Drug AdministrationFDA banFactor βSyndromeMyalgiaEosinophiliaNeuropathyHistopathologicIndurationIncidenceAdministration
2009
A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: selective modulation by imatinib mesylate
Bhattacharyya S, Ishida W, Wu M, Wilkes M, Mori Y, Hinchcliff M, Leof E, Varga J. A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: selective modulation by imatinib mesylate. Oncogene 2009, 28: 1285-1297. PMID: 19151753, PMCID: PMC4006376, DOI: 10.1038/onc.2008.479.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzamidesBleomycinCells, CulturedCollagenEarly Growth Response Protein 1Extracellular Signal-Regulated MAP KinasesFibroblastsFibrosisHumansImatinib MesylateMiceMice, Inbred BALB CNIH 3T3 CellsPiperazinesProtein Kinase InhibitorsProto-Oncogene Proteins c-ablPyrimidinesSignal TransductionSmad2 ProteinSmad3 ProteinTransforming Growth Factor betaConceptsChronic myelogenous leukemiaFibrotic responseEgr-1Growth factorUpregulated tissue expressionFibrosis of skinNovel therapeutic approachesEarly growth response factor-1Kinase-deficient mutant formC-AblNormal fibroblastsTGF-β stimulationIntracellular signaling mechanismLesional skinStimulation of collagenImatinib mesylateMouse embryonic fibroblastsFibrotic processMyelogenous leukemiaTherapeutic approachesPharmacological targetingTarget of inhibitionTGF-β responseFibroblast activationC-Abl activation