2016
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing
Thomer L, Emolo C, Thammavongsa V, Kim H, McAdow M, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Journal Of Experimental Medicine 2016, 213: 293-301. PMID: 26880578, PMCID: PMC4813671, DOI: 10.1084/jem.20150074.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusBloodstream infectionsPhagocytic killingElicit cross-protective immune responsesCross-protective immune responsesProtective fibrin shieldS. aureus vaccineAureus vaccineClinical efficacyMRSA isolatesImmune cellsOpsonophagocytic killingFrequent causeImmune responseHost immunityHost prothrombinProtective antigenSpecific antibodiesInfectionSurface moleculesAntibodiesS. aureusStaphylococcus aureusAntibody therapeuticsStaphylococcal surface
2011
Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood
McAdow M, Kim HK, DeDent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood. PLOS Pathogens 2011, 7: e1002307. PMID: 22028651, PMCID: PMC3197598, DOI: 10.1371/journal.ppat.1002307.Peer-Reviewed Original ResearchMeSH KeywordsAgglutinationAnimalsAntibodies, NeutralizingAntithrombinsBacterial ProteinsCarrier ProteinsCoagulantsCoagulaseDisease Models, AnimalHeartHost-Pathogen InteractionsHumansImmunization, PassiveLongevityMiceMice, Inbred BALB CMyocardiumProtein BindingSepsisStaphylococcal InfectionsStaphylococcus aureusVon Willebrand FactorConceptsAureus sepsisLethal outcomeDabigatran etexilate treatmentS. aureus sepsisDirect thrombin inhibitorStaphylococcus aureus sepsisStaphylococcus aureus infectionVon Willebrand factorThromboembolic lesionsStaphylococcal sepsisAureus infectionFrequent causeMouse modelSepsisDisease pathogenesisHigh mortalityThrombin inhibitorsBacterial factorsSpecific interventionsHeart tissueWillebrand factorFibrin cableVirulence genesAgglutinationDisease
2010
IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
Kim HK, DeDent A, Cheng AG, McAdow M, Bagnoli F, Missiakas DM, Schneewind O. IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine 2010, 28: 6382-6392. PMID: 20226248, PMCID: PMC3095377, DOI: 10.1016/j.vaccine.2010.02.097.Peer-Reviewed Original ResearchConceptsIntravenous challengeAbscess formationStaphylococcus aureus abscess formationLethal intravenous challengePathogenesis of infectionHospital-acquired infectionsStaphylococcal abscess formationNaïve miceActive immunizationLethal challengeSurface proteinsOpsonophagocytic killingStaphylococcal diseaseFrequent causeSubunit vaccineExperimental animalsMouse bloodAntibodiesStaphylococcus aureusBind hemoglobinVaccineInfectionMiceStaphylococciBacteremia