Featured Publications
Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry
Sawano M, Spertus J, Masoudi F, Rumsfeld J, Numasawa Y, Inohara T, Kennedy K, Ueda I, Miyata H, Fukuda K, Kohsaka S. Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry. American Heart Journal 2021, 235: 113-124. PMID: 33472053, DOI: 10.1016/j.ahj.2021.01.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransfemoral approachTransradial approachNational Cardiovascular Data Registry CathPCI RegistryVascular closure device usePercutaneous coronary intervention outcomesMultivariable logistic regression analysisClosure device useConsecutive PCI patientsJapanese multicenter registryAdjusted odds ratioLogistic regression analysisPCI patientsCathPCI RegistryCoronary interventionMulticenter registryBleeding rateJapanese patientsOdds ratioRisk scoreLower riskPatientsUS populationCathPCIJapanese population
2022
One-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry
Otowa K, Kohsaka S, Sawano M, Matsuura S, Chikata A, Maruyama M, Usuda K, Watanabe T, Ishii H, Amano T, Nakamura M, Ikari Y. One-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry. American Heart Journal 2022, 246: 105-116. PMID: 35016854, DOI: 10.1016/j.ahj.2022.01.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse cardiovascular eventsLong-term outcomesCardiovascular eventsNonagenarian patientsCardiovascular mortalityCoronary interventionOutcomes RegistryMajor adverse cardiovascular eventsCV death rateMajor bleeding eventsOne-year outcomesNationwide registration systemPatient-level dataLong-term survivalYears of ageMultivariate regression analysisBleeding eventsCardiogenic shockMajor bleedingOral anticoagulantsAdverse eventsElder patientsCardiac arrestLesion characteristics
2021
Sudden cardiac death after acute decompensation in heart failure patients: implications of discharge haemoglobin levels
Fukuoka R, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Levy W, Nagatomo Y, Nishihata Y, Goda A, Kohno T, Kawamura A, Fukuda K, Yoshikawa T. Sudden cardiac death after acute decompensation in heart failure patients: implications of discharge haemoglobin levels. ESC Heart Failure 2021, 8: 3917-3928. PMID: 34323007, PMCID: PMC8497203, DOI: 10.1002/ehf2.13414.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDeath, Sudden, CardiacHeart FailureHemoglobinsHumansMaleMiddle AgedPatient DischargeProspective StudiesConceptsSudden cardiac deathPump failure deathAcute HF patientsDischarge Hb levelsHeart failure patientsMode of deathHb levelsHF patientsFailure patientsCardiac deathEjection fractionHemoglobin levelsIncidence of SCDConsecutive acute HF patientsSeattle Proportional Risk ModelDischarge hemoglobin levelsProspective multicentre registryBaseline ejection fractionMean Hb levelNon-cardiovascular causesSeverity of anemiaSCD risk predictionProportional risk modelFailure deathHF managementEvidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Noma S, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Evidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention. Journal Of The American Heart Association 2021, 10: e020047. PMID: 34310187, PMCID: PMC8475676, DOI: 10.1161/jaha.120.020047.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overClinical Decision-MakingContrast MediaDatabases, FactualEvidence-Based MedicineFemaleHumansIncidenceJapanKidneyKidney Function TestsMaleMiddle AgedPercutaneous Coronary InterventionProfessional Practice GapsProtective FactorsQuality ImprovementQuality Indicators, Health CareRadiography, InterventionalRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeConceptsAcute kidney injuryPercutaneous coronary interventionAKI risk scoreBaseline renal functionContrast volumeCoronary interventionRisk scoreAKI riskKidney injuryRenal functionAcute coronary syndrome presentationBackground Acute kidney injuryIntra-aortic balloon pumpMultivariable linear regression analysisContrast volume usagePreprocedural risk assessmentChronic kidney diseaseAvailable risk scoresCommon complicationBalloon pumpHeart failureSusceptible patientsOverall incidenceSyndrome presentationKidney diseaseOne-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―
Sawano M, Kohsaka S, Ishii H, Numasawa Y, Yamaji K, Inohara T, Amano T, Ikari Y, Nakamura M. One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―. Circulation Journal 2021, 85: 1756-1767. PMID: 34162778, DOI: 10.1253/circj.cj-21-0098.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionST-elevation myocardial infarctionHeart failureHospital survivorsCoronary interventionIschemic strokeUnstable anginaMyocardial infarctionHigh riskAcute myocardial infarction populationNon-fatal ischemic strokeLate adverse cardiac eventsJapanese nationwide cohortJapanese nationwide registryNon-cardiac deathAcute heart failureAdverse cardiac eventsAcute coronary syndromeHeart failure eventsOne-year outcomesElevation myocardial infarctionSudden cardiac deathMyocardial infarction populationQuality of careACS patientsFemale sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis
Kodaira M, Sawano M, Tanaka M, Kuno T, Numasawa Y, Ueda I, Fukuda K, Kohsaka S. Female sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis. Journal Of Cardiology 2021, 78: 431-438. PMID: 34172350, DOI: 10.1016/j.jjcc.2021.05.016.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeFine-Gray modelPrimary outcomeFemale sexPercutaneous coronary intervention patientsLower body mass indexEtiology of readmissionMulticenter PCI registryPrevious heart failureUnadjusted readmission ratesAdjusted hazard ratioHigh bleeding riskBody mass indexLong-term outcomesCox regression modelACS survivorsCumulative incidence functionMajor bleedingMore comorbiditiesBleeding riskCoronary syndromeIntervention patientsPCI registryCoronary interventionA Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation
Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y, Group F. A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation. Circulation Journal 2021, 85: 1254-1262. PMID: 33762526, DOI: 10.1253/circj.cj-20-1075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsAtrial FibrillationBrain IschemiaHumansIschemic StrokeJapanRisk AssessmentRisk FactorsStrokeConceptsJapanese NVAF patientsIndependent risk factorIschemic strokeNVAF patientsRisk factorsAF RegistryHazard ratioC-statisticJapanese non-valvular atrial fibrillation (NVAF) patientsNon-valvular atrial fibrillation patientsCox hazard proportional analysisNovel risk stratification systemNon-valvular atrial fibrillationLower body mass indexFushimi AF RegistryIschemic stroke eventsJ-RHYTHM RegistryAtrial fibrillation patientsOral anticoagulant treatmentBody mass indexSignificant risk factorsRisk stratification systemType of AFVASc scoreAnticoagulant treatment
2020
Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial
Sawano M, Katsuki T, Kitai T, Tamita K, Obunai K, Ikegami Y, Yamane T, Ueda I, Endo A, Maekawa Y, Kawamura A, Fukuda K, Kohsaka S. Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial. Open Heart 2020, 7: e001406. PMID: 33087441, PMCID: PMC7580072, DOI: 10.1136/openhrt-2020-001406.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngina PectorisCalcium Channel BlockersCoronary Artery DiseaseCoronary VasospasmDrug-Eluting StentsFemaleHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionProspective StudiesProtective FactorsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsMajor cardiovascular eventsPercutaneous coronary interventionCalcium channel blockersCoronary artery diseaseStable coronary artery diseaseDrug-eluting stent implantationAcetylcholine provocation testingDiagnostic coronary angiographyBeta blockersCCB groupArtery diseaseCoronary angiographyVasospastic anginaCoronary revascularisationProvocation testingStent implantationChannel blockersSecond-generation drug-eluting stent implantationUniversity Hospital Medical Information Network Clinical Trials RegistryIndex percutaneous coronary interventionNon-fatal myocardial infarctionSingle-vessel lesionsSubsequent coronary eventsCoronary artery spasmClinical Trials RegistryGuideline-Based Medications for Older Adults Discharged after Percutaneous Coronary Intervention in a Suburban City of Japan: A Cohort Study Using Claims Data
Shimada K, Hamada S, Sawano M, Yamamoto H, Yoshie S, Iijima K, Miyata H. Guideline-Based Medications for Older Adults Discharged after Percutaneous Coronary Intervention in a Suburban City of Japan: A Cohort Study Using Claims Data. The Tohoku Journal Of Experimental Medicine 2020, 252: 143-152. PMID: 33028759, DOI: 10.1620/tjem.252.143.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsFemaleGeriatricsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInsurance Claim ReviewJapanMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPatient DischargePercutaneous Coronary InterventionPractice Guidelines as TopicRetrospective StudiesSecondary PreventionConceptsPercutaneous coronary interventionGuideline-based medicationsSecondary preventionΒ-blockersCohort studyCoronary interventionPrescription ratesClaims dataMultivariable logistic regression analysisOlder groupOlder adultsPrescription of antiplateletACEI/ARBRetrospective cohort studyAssociation of ageLogistic regression analysisCardiovascular eventsReceptor blockersAdjusted analysisBetter prognosisEnzyme inhibitorsMedicationsCommunity settingsStatinsPreventionIschemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Ikemura N, Ueno K, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment. JAMA Network Open 2020, 3: e202004. PMID: 32239221, PMCID: PMC7118520, DOI: 10.1001/jamanetworkopen.2020.2004.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAspirinBrain IschemiaCase-Control StudiesClopidogrelDeathDrug Therapy, CombinationFemaleHemorrhageHumansJapanMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrasugrel HydrochlorideRegistriesRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentStrokeConceptsLow-dose prasugrelPercutaneous coronary interventionPrimary ischemic eventsAcute coronary syndromeBleeding eventsIschemic eventsCoronary syndromeST-segment elevation myocardial infarctionAcute Coronary Syndrome AssociatedPropensity score-matched analysisHigh-bleeding riskStandard-dose clopidogrelChronic kidney diseaseElevation myocardial infarctionPresent cohort studyShort-term outcomesEast Asian patientsReal-world outcomesPrasugrel treatmentClopidogrel administrationP2Y12 inhibitorsBaseline characteristicsClopidogrel treatmentCohort studyCoronary interventionRisk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation
Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y. Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation. JAMA Network Open 2020, 3: e202881. PMID: 32293685, PMCID: PMC7160687, DOI: 10.1001/jamanetworkopen.2020.2881.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsAsian PeopleAtrial FibrillationBrain IschemiaCohort StudiesFemaleHumansJapanMaleRisk FactorsConceptsNonvalvular atrial fibrillationFushimi AF RegistryJ-RHYTHM RegistryRisk stratification schemesIschemic strokeAF RegistryBody mass indexRisk factorsAtrial fibrillationJapanese patientsPermanent AFPrevious strokeMass indexShinken DatabaseStratification schemesCox proportional hazards analysisLower body mass indexOral anticoagulant useIndependent risk factorProportional hazards analysisSignificant risk factorsIndividual patient dataValvular AFAnticoagulant useCohort studyTransradial Percutaneous Coronary Intervention in Patients With Advanced Chronic Kidney Disease
Yashima F, Inohara T, Numasawa Y, Kuno T, Sawano M, Ueno K, Shimoji K, Noma S, Fukuda K, Kohsaka S. Transradial Percutaneous Coronary Intervention in Patients With Advanced Chronic Kidney Disease. Cardiovascular Revascularization Medicine 2020, 21: 1138-1143. PMID: 32089511, DOI: 10.1016/j.carrev.2020.02.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransradial interventionTransfemoral interventionAdvanced CKDCKD patientsHemodialysis initiationPCI patientsCoronary interventionPropensity matchingAdvanced chronic kidney diseaseMore procedure-related complicationsChronic kidney disease patientsTransradial percutaneous coronary interventionConsecutive PCI patientsMulticenter Japanese registryAcute kidney injuryChronic kidney diseaseProcedure-related complicationsGlomerular filtration rateKidney disease patientsOutcomes of interestAKI riskKidney injuryClinical outcomesPeriprocedural bleeding
2019
Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
Kodaira M, Sawano M, Kuno T, Numasawa Y, Noma S, Suzuki M, Imaeda S, Ueda I, Fukuda K, Kohsaka S. Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study. PLOS ONE 2019, 14: e0223215. PMID: 31618228, PMCID: PMC6795465, DOI: 10.1371/journal.pone.0223215.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overCerebrovascular DisordersFemaleHospital MortalityHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPeripheral Vascular DiseasesPostoperative HemorrhageRadial ArteryRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeConceptsTransradial coronary interventionAcute coronary syndromePeripheral arterial diseaseCerebrovascular diseaseCoronary interventionVascular diseaseRetrospective multicenter cohort studyAcute coronary syndrome patientsPercutaneous coronary intervention registryMulticenter cohort studyCoronary syndrome patientsCoronary Intervention RegistryIncidence of deathCoronary syndromeCohort studyIntervention RegistryArterial diseaseAdverse outcomesRisk factorsPatient outcomesAccess siteSyndrome patientsHigh riskComplicationsPatientsDiscrepancy between patient-reported quality of life and the prognostic assessment of Japanese patients hospitalized with acute heart failure
Shoji S, Shiraishi Y, Sawano M, Katsumata Y, Yuasa S, Kohno T, Fukuda K, Spertus J, Kohsaka S. Discrepancy between patient-reported quality of life and the prognostic assessment of Japanese patients hospitalized with acute heart failure. Heart And Vessels 2019, 34: 1464-1470. PMID: 30887105, DOI: 10.1007/s00380-019-01378-1.Peer-Reviewed Original ResearchConceptsClinical risk scorePatient-reported qualityLong-term prognosisHeart failureHHF patientsRisk scoreComposite outcomeAcute settingGWTG-HF risk scoreHospitalized HF patientsAcute heart failureChronic heart failurePrimary therapeutic targetHealth care providersFirst yearCause mortalityHF patientsHF readmissionPatient characteristicsIndependent predictorsAcute phasePrognostic indicatorJapanese patientsPrognostic assessmentCare providersComparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry)
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Kadota K, Shiode N, Tanaka N, Amano T, Uemura S, Akasaka T, Morino Y, Fujii K, Hikichi H, Kohsaka S, Ishii H, Tanabe K, Ozaki Y, Sumitsuji S, Iida O, Hara H, Takashima H, Shirai S, Nanasato M, Inohara T, Ueda Y, Numasawa Y, Noma S. Comparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry). Journal Of The American Heart Association 2019, 8: e011183. PMID: 30791799, PMCID: PMC6474917, DOI: 10.1161/jaha.118.011017.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeOlder patientsHospital mortalityElderly patientsCoronary interventionNationwide registryYounger patientsTransradial interventionStable coronary artery diseaseConclusion Older patientsJapanese nationwide registryProspective nationwide registryChronic kidney diseaseCoronary artery diseaseComparison of outcomesYears of ageCardiac tamponadeCardiogenic shockCoronary syndromeHospital deathHospital outcomesPeriprocedural complicationsArtery diseaseBlood transfusion
2018
Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention
Shoji S, Kohsaka S, Kumamaru H, Sawano M, Shiraishi Y, Ueda I, Noma S, Suzuki M, Numasawa Y, Hayashida K, Yuasa S, Miyata H, Fukuda K. Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention. Circulation Cardiovascular Interventions 2018, 11: e006761. PMID: 30545258, DOI: 10.1161/circinterventions.118.006761.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPeriprocedural strokeTransradial interventionTransfemoral interventionCoronary interventionAccess siteElective percutaneous coronary interventionPropensity score-matched analysisMultivariable logistic regression analysisOptimal access siteProspective multicenter databaseAcute kidney injuryAcute coronary syndromeChronic kidney diseaseLife-threatening complicationsPeripheral artery diseaseLogistic regression analysisCoronary syndromeHemorrhagic eventsKidney injuryPCI complicationsArtery diseaseMulticenter databaseStroke patientsKidney diseaseAn overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry
Numasawa Y, Inohara T, Ishii H, Yamaji K, Hirano K, Kohsaka S, Sawano M, Kuno T, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Investigators O. An overview of percutaneous coronary intervention in dialysis patients: Insights from a Japanese nationwide registry. Catheterization And Cardiovascular Interventions 2018, 94: e1-e8. PMID: 30467967, DOI: 10.1002/ccd.27986.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionJapanese nationwide registryDialysis patientsHospital mortalityNondialysis patientsCoronary interventionNationwide registryACS cohortHeart failureAdverse outcomesAcute heart failureMore comorbiditiesCardiogenic shockHospital outcomesBlood transfusionClinical trialsFemale genderPCI casesPatientsJapanese hospitalsGreater riskMortalityComplicationsRegistryRiskValidation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan
Nagai T, Sundaram V, Shoaib A, Shiraishi Y, Kohsaka S, Rothnie K, Piper S, McDonagh T, Hardman S, Goda A, Mizuno A, Sawano M, Rigby A, Quint J, Yoshikawa T, Clark A, Anzai T, Cleland J. Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan. European Journal Of Heart Failure 2018, 20: 1179-1190. PMID: 29846026, DOI: 10.1002/ejhf.1210.Peer-Reviewed Original Research
2017
Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry
Sawano M, Kohsaka S, Abe T, Inohara T, Maekawa Y, Ueda I, Sueyoshi K, Suzuki M, Noma S, Numasawa Y, Miyata H, Fukuda K, Smolderen KG, Spertus JA. Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry. PLOS ONE 2017, 12: e0182687. PMID: 28817616, PMCID: PMC5560610, DOI: 10.1371/journal.pone.0182687.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseCoronary artery diseasePCI patientsStatin therapyArtery diseaseKidney diseaseHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisPercutaneous coronary intervention registryJapanese PCI registryStatin prescription patternsCoronary Intervention RegistryLow-intensity statinsLogistic regression analysisCardiovascular eventsPCI registryIntervention RegistryPatient characteristicsPrescription patternsReal-world practiceStudy registryEffective medicationsHigh riskPatientsHigher ageCurrent use of guideline-based medical therapy in elderly patients admitted with acute heart failure with reduced ejection fraction and its impact on event-free survival
Akita K, Kohno T, Kohsaka S, Shiraishi Y, Nagatomo Y, Izumi Y, Goda A, Mizuno A, Sawano M, Inohara T, Fukuda K, Yoshikawa T, Investigators W. Current use of guideline-based medical therapy in elderly patients admitted with acute heart failure with reduced ejection fraction and its impact on event-free survival. International Journal Of Cardiology 2017, 235: 162-168. PMID: 28259550, DOI: 10.1016/j.ijcard.2017.02.070.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsFemaleHeart FailureHumansJapanMaleMedication Therapy ManagementMiddle AgedNeeds AssessmentOutcome and Process Assessment, Health CarePatient DischargePatient ReadmissionPractice Guidelines as TopicStroke VolumeVentricular Dysfunction, LeftConceptsGuideline-based medical therapyAcute heart failureReduced ejection fractionElderly patientsHeart failureEjection fractionHF readmissionMedical therapyWest Tokyo Heart Failure registryConsecutive acute HF patientsYounger groupAcute HF patientsElderly HFrEF patientsHeart Failure RegistryEvent-free survivalMulti-center registryIdeal therapeutic approachHF rehospitalizationHFrEF patientsHF patientsCurrent useCardiac deathComposite endpointPrescription ratesPoor outcome