2024
Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic
Faust J, Renton B, Bongiovanni T, Chen A, Sheares K, Du C, Essien U, Fuentes-Afflick E, Haywood T, Khera R, King T, Li S, Lin Z, Lu Y, Marshall A, Ndumele C, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor H, Watson K, Yancy C, Krumholz H. Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2438918. PMID: 39392630, DOI: 10.1001/jamanetworkopen.2024.38918.Peer-Reviewed Original ResearchConceptsCOVID-19 public health emergencyNon-HispanicPublic health emergencyOther Pacific IslanderExcess mortalityAlaska NativesUS populationExcess deathsRates of excess mortalityCross-sectional study analyzed dataYears of potential lifeMortality relative riskNon-Hispanic whitesCross-sectional studyPacific IslandersStudy analyzed dataAll-cause mortalityEthnic groupsMortality disparitiesMortality ratioTotal populationDeath certificatesEthnic disparitiesMain OutcomesDecedent ageCause-Specific Mortality Rates Among the US Black Population
Arun A, Caraballo C, Sawano M, Lu Y, Khera R, Yancy C, Krumholz H. Cause-Specific Mortality Rates Among the US Black Population. JAMA Network Open 2024, 7: e2436402. PMID: 39348122, PMCID: PMC11443349, DOI: 10.1001/jamanetworkopen.2024.36402.Peer-Reviewed Original ResearchHypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records
Brush J, Lu Y, Liu Y, Asher J, Li S, Sawano M, Young P, Schulz W, Anderson M, Burrows J, Krumholz H. Hypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records. Journal Of The American Heart Association 2024, 13: e033253. PMID: 38686864, PMCID: PMC11179912, DOI: 10.1161/jaha.123.033253.Peer-Reviewed Original ResearchConceptsElectronic health recordsRegional health systemImprove hypertension careHealth systemHealth recordsHypertension careDiastolic blood pressureAge-adjusted prevalence ratesNon-Hispanic Black patientsPrevalence ratesLarger health systemCross-sectional analysisTransformation of medical dataLeveraging real-world dataHigh prevalence rateHypertension trendsHypertension prevalenceBlood pressureBlood pressure measurementsHypertension diagnosisPrimary outcomeNational trendsProportion of patientsAntihypertensive medicationsBlack patients
2023
Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan
Kuno T, Miyamoto Y, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan. The American Journal Of Cardiology 2023, 206: 151-160. PMID: 37703680, DOI: 10.1016/j.amjcard.2023.08.106.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary end pointLong-term outcomesYounger patientsCause deathCoronary interventionOlder patientsMale patientsAcute coronary syndrome casesPrimary end point ratesLong-term outcome analysisST-elevation myocardial infarctionEnd pointUnderwent Percutaneous Coronary InterventionWorse long-term outcomesYoung womenCoronary artery bypassAcute coronary syndromeConsecutive young patientsYoung female patientProportion of smokingNoncardiac deathArtery bypassCoronary syndromeMulticenter registry
2020
Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan
Nishimura S, Kumamaru H, Shoji S, Sawano M, Kohsaka S, Miyata H. Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan. Hypertension Research 2020, 43: 705-714. PMID: 32313192, DOI: 10.1038/s41440-020-0440-2.Peer-Reviewed Original ResearchConceptsLow adherenceAntihypertensive medicationsAntihypertensive drugsJapanese patientsLarge administrative claims databaseAntihypertensive drug usersInitiation of angiotensinAdministrative claims databaseSuboptimal clinical outcomesProportion of daysNon-elderly adultsLogistic regression analysisHypertensive patientsThiazide diureticsClinical outcomesClaims databaseFemale sexHigh adherencePatientsEnzyme inhibitorsDrug usersYounger ageTargeted interventionsFacility characteristicsLarge hospitalsElectrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010
Shoji S, Kohsaka S, Sawano M, Okamura T, Hirata A, Sugiyama D, Ohkubo T, Nakamura Y, Watanabe M, Kadota A, Ueshima H, Okayama A, Miura K, Group F. Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010. Journal Of Atherosclerosis And Thrombosis 2020, 28: 34-43. PMID: 32188793, PMCID: PMC7875149, DOI: 10.5551/jat.54171.Peer-Reviewed Original ResearchConceptsFuture cardiovascular eventsBNP concentrationsCardiovascular eventsElevated BNPGeneral populationB-type natriuretic peptide concentrationsElectrocardiographic Left Atrial AbnormalityJapanese Circulation Society guidelinesB-type natriuretic peptideP-wave terminal forceContemporary general populationEarliest detectable markerElevated BNP concentrationsHistory of hypertensionNatriuretic peptide concentrationsJapanese populationGeneral population cohortHigher BNP concentrationsRepresentative Japanese populationGeneral Japanese populationLeft atrial abnormalityAtrial pressureElectrocardiogram (ECG) markersElectrocardiographic findingsNatriuretic peptide
2016
Validation of the european SCORE risk chart in the healthy middle-aged Japanese
Sawano M, Kohsaka S, Okamura T, Inohara T, Sugiyama D, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okud N, Murakami Y, Ohkubo T, Fujiyoshi A, Miura K, Okayama A, Ueshima H, Group F. Validation of the european SCORE risk chart in the healthy middle-aged Japanese. Atherosclerosis 2016, 252: 116-121. PMID: 27521900, DOI: 10.1016/j.atherosclerosis.2016.07.926.Peer-Reviewed Original ResearchConceptsCardiovascular death riskMiddle-aged JapaneseC-statisticDeath riskScore modelEuropean SCORE risk chartsOverall populationHarrel's c-statisticsSCORE risk chartsJapanese general populationHigh-risk populationGeneral Japanese populationCV deathRisk chartsGeneral populationEuropean SocietyJapanese populationDifferent ethnicitiesWomenPoor calibrationReasonable discriminationRiskMenPopulationTen yearsIndependent Prognostic Value of Single and Multiple Non-Specific 12-Lead Electrocardiographic Findings for Long-Term Cardiovascular Outcomes: A Prospective Cohort Study
Sawano M, Kohsaka S, Okamura T, Inohara T, Sugiyama D, Shiraishi Y, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okuda N, Murakami Y, Ohkubo T, Fujiyoshi A, Miura K, Okayama A, Ueshima H, . Independent Prognostic Value of Single and Multiple Non-Specific 12-Lead Electrocardiographic Findings for Long-Term Cardiovascular Outcomes: A Prospective Cohort Study. PLOS ONE 2016, 11: e0157563. PMID: 27362562, PMCID: PMC4928789, DOI: 10.1371/journal.pone.0157563.Peer-Reviewed Original ResearchConceptsFramingham risk scoreCardiovascular deathRisk chartsRisk scoreCohort studyLong-term cardiovascular deathLong-term prognostic effectLong-term cardiovascular outcomesProspective cohort studyIndependent prognostic valueLongitudinal cohort studyRisk stratification systemCause deathCardiovascular outcomesCoronary deathElectrocardiogram findingsHazard ratioPrognostic impactStroke deathsElectrocardiographic findingsPrognostic effectPrognostic valueHealthy menRepolarization abnormalitiesHigh riskEnhanced oxidative stress is associated with sleep-disordered breathing and obesity in patients with heart failure
Kondo M, Kohno T, Kohsaka S, Fukuoka R, Shiraishi Y, Sawano M, Inohara T, Sano M, Yoshikawa T, Fukuda K. Enhanced oxidative stress is associated with sleep-disordered breathing and obesity in patients with heart failure. International Journal Of Cardiology 2016, 209: 133-135. PMID: 26889597, DOI: 10.1016/j.ijcard.2016.02.042.Peer-Reviewed Original Research
2015
Validation of the Get With The Guideline–Heart Failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide level
Shiraishi Y, Kohsaka S, Abe T, Mizuno A, Goda A, Izumi Y, Yagawa M, Akita K, Sawano M, Inohara T, Takei M, Kohno T, Higuchi S, Yamazoe M, Mahara K, Fukuda K, Yoshikawa T, Investigators W. Validation of the Get With The Guideline–Heart Failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide level. American Heart Journal 2015, 171: 33-39. PMID: 26699598, DOI: 10.1016/j.ahj.2015.10.008.Peer-Reviewed Original ResearchConceptsB-type natriuretic peptide levelsGWTG-HF risk scoreAcute heart failureNatriuretic peptide levelsHospital mortalityRisk scorePeptide levelsAHF patientsC-statisticGuidelines-Heart Failure (GWTG-HF) risk scoreWest Tokyo Heart Failure registryChronic obstructive pulmonary diseaseBlood urea nitrogen levelsGWTG-HF scoreHeart Failure RegistryMulticenter cohort registryRisk score performanceObstructive pulmonary diseaseSystolic blood pressureUrea nitrogen levelsHosmer-Lemeshow statisticFuture risk modelsCohort registryBlood pressureHeart failure
2014
Coexistence of two distinct fascinating cardiovascular disorders: Heterotaxy syndrome with left ventricular non-compaction and vasospastic angina
Egashira T, Yuasa S, Kimura M, Sawano M, Anzai A, Hayashida K, Kawamura A, Kimura T, Nishiyama N, Aizawa Y, Takatsuki S, Tsuruta H, Murata M, Yamada Y, Kohno T, Maekawa Y, Sano M, Kosaki K, Fukuda K. Coexistence of two distinct fascinating cardiovascular disorders: Heterotaxy syndrome with left ventricular non-compaction and vasospastic angina. International Journal Of Cardiology 2014, 174: e54-e56. PMID: 24768391, DOI: 10.1016/j.ijcard.2014.04.032.Peer-Reviewed Original Research