Featured Publications
Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry
Sawano M, Spertus J, Masoudi F, Rumsfeld J, Numasawa Y, Inohara T, Kennedy K, Ueda I, Miyata H, Fukuda K, Kohsaka S. Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry. American Heart Journal 2021, 235: 113-124. PMID: 33472053, DOI: 10.1016/j.ahj.2021.01.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransfemoral approachTransradial approachNational Cardiovascular Data Registry CathPCI RegistryVascular closure device usePercutaneous coronary intervention outcomesMultivariable logistic regression analysisClosure device useConsecutive PCI patientsJapanese multicenter registryAdjusted odds ratioLogistic regression analysisPCI patientsCathPCI RegistryCoronary interventionMulticenter registryBleeding rateJapanese patientsOdds ratioRisk scoreLower riskPatientsUS populationCathPCIJapanese populationPerformance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides
Sawano M, Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Sujino Y, Nagatomo Y, Kohno T, Anzai T, Fukuda K, Yoshikawa T. Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides. ESC Heart Failure 2018, 5: 610-619. PMID: 29520978, PMCID: PMC6073038, DOI: 10.1002/ehf2.12278.Peer-Reviewed Original ResearchConceptsMAGGIC scoreBNP levelsB-type natriuretic peptide levelsAcute Heart Failure registryChronic Heart Failure (MAGGIC) scoreConsecutive acute HF patientsHeart failure patient outcomesHeart Failure Risk ScoreMeta-Analysis Global GroupAcute HF patientsHeart Failure RegistryHeart failure scoreProspective multicentre registryIncremental prognostic valueNatriuretic peptide levelsHeart failure patientsMulticentre registryHF patientsFailure patientsYear mortalityNatriuretic peptidePatient mortalityPrognostic valueMean ageJapanese RegistryContemporary use and trends in percutaneous coronary intervention in Japan: an outline of the J-PCI registry
Sawano M, Yamaji K, Kohsaka S, Inohara T, Numasawa Y, Ando H, Iida O, Shinke T, Ishii H, Amano T. Contemporary use and trends in percutaneous coronary intervention in Japan: an outline of the J-PCI registry. Cardiovascular Intervention And Therapeutics 2020, 35: 218-226. PMID: 32440831, PMCID: PMC7295726, DOI: 10.1007/s12928-020-00669-z.Peer-Reviewed Original Research
2023
Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry
Kuno T, Ohata T, Nakamaru R, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry. Scientific Reports 2023, 13: 20318. PMID: 37985895, PMCID: PMC10662469, DOI: 10.1038/s41598-023-47444-7.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLong-term outcomesCoronary dissectionPrimary endpointCoronary perforationCoronary interventionHeart failurePrimary outcomeMultivariable Cox hazards regression modelIndex percutaneous coronary interventionCox hazard regression modelPoor long-term outcomesIatrogenic coronary dissectionJapanese multicenter registryMulticenter prospective registryCoronary artery bypassAcute coronary syndromeHeart failure readmissionContrast medium extravasationHazards regression modelsPersistent filling defectSignificant differencesHigh rateCause deathArtery bypassOne‐year outcomes of patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy catheter: Insights from the J‐PCI OUTCOME registry
Numasawa Y, Sawano M, Ishii H, Kohsaka S, Kikuta Y, Matoba T, Amano T, Kozuma K, Investigators T. One‐year outcomes of patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy catheter: Insights from the J‐PCI OUTCOME registry. Catheterization And Cardiovascular Interventions 2023, 102: 1229-1237. PMID: 37943854, DOI: 10.1002/ccd.30895.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsDirectional coronary atherectomyPercutaneous coronary interventionStable coronary artery diseaseOne-year outcomesCoronary artery diseaseMajor bleedingCoronary interventionUnstable anginaArtery diseaseDCA groupContemporary real-world practiceDrug-coated balloon angioplastyOne-year clinical outcomesJapanese nationwide registryNonfatal major bleedingAdverse cardiovascular eventsCardiovascular deathCardiovascular eventsCause mortalityMidterm outcomesBaseline characteristicsCardiovascular mortalityCoronary atherectomyNationwide registryGender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan
Kuno T, Miyamoto Y, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan. The American Journal Of Cardiology 2023, 206: 151-160. PMID: 37703680, DOI: 10.1016/j.amjcard.2023.08.106.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary end pointLong-term outcomesYounger patientsCause deathCoronary interventionOlder patientsMale patientsAcute coronary syndrome casesPrimary end point ratesLong-term outcome analysisST-elevation myocardial infarctionEnd pointUnderwent Percutaneous Coronary InterventionWorse long-term outcomesYoung womenCoronary artery bypassAcute coronary syndromeConsecutive young patientsYoung female patientProportion of smokingNoncardiac deathArtery bypassCoronary syndromeMulticenter registryIschemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry)
Tobe A, Sawano M, Kohsaka S, Ishii H, Tanaka A, Numasawa Y, Amano T, Nakamura M, Ikari Y, Murohara T. Ischemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry). The American Journal Of Cardiology 2023, 195: 37-44. PMID: 37004333, DOI: 10.1016/j.amjcard.2023.02.027.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePercutaneous coronary interventionPresence of CKDCKD stages 1Ischemic eventsAdjustment of covariatesHigh riskPCI registryCoronary interventionKidney diseaseNew-generation drug-eluting stent implantationDrug-eluting stent implantationUnderwent Percutaneous Coronary InterventionCKD stage 3Stage 1Bleeding eventsBleeding outcomesDialysis groupOral anticoagulantsCKD 3Renal functionStent implantationIncidence ratePatientsCare delivery
2022
Machine learning models for prediction of adverse events after percutaneous coronary intervention
Niimi N, Shiraishi Y, Sawano M, Ikemura N, Inohara T, Ueda I, Fukuda K, Kohsaka S. Machine learning models for prediction of adverse events after percutaneous coronary intervention. Scientific Reports 2022, 12: 6262. PMID: 35428765, PMCID: PMC9012739, DOI: 10.1038/s41598-022-10346-1.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse eventsRisk scoreHospital mortalityCoronary interventionConsecutive coronary artery disease patientsCoronary artery disease patientsAdverse periprocedural eventsLow-risk patientsMajor adverse eventsGood discriminationMulticenter registryPeriprocedural eventsDisease patientsClinical decisionLogistic regressionSpecific interventionsRisk predictionOverall risk predictionPatientsScoresInterventionMortalityAdequate discriminationOutcomesJapanese Nationwide PCI (J-PCI) Registry Annual Report 2019: patient demographics and in-hospital outcomes
Ando H, Yamaji K, Kohsaka S, Ishii H, Wada H, Yamada S, Sawano M, Inohara T, Numasawa Y, Ikari Y, Amano T. Japanese Nationwide PCI (J-PCI) Registry Annual Report 2019: patient demographics and in-hospital outcomes. Cardiovascular Intervention And Therapeutics 2022, 37: 243-247. PMID: 35020153, PMCID: PMC8753025, DOI: 10.1007/s12928-021-00832-0.Peer-Reviewed Original ResearchOne-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry
Otowa K, Kohsaka S, Sawano M, Matsuura S, Chikata A, Maruyama M, Usuda K, Watanabe T, Ishii H, Amano T, Nakamura M, Ikari Y. One-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry. American Heart Journal 2022, 246: 105-116. PMID: 35016854, DOI: 10.1016/j.ahj.2022.01.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse cardiovascular eventsLong-term outcomesCardiovascular eventsNonagenarian patientsCardiovascular mortalityCoronary interventionOutcomes RegistryMajor adverse cardiovascular eventsCV death rateMajor bleeding eventsOne-year outcomesNationwide registration systemPatient-level dataLong-term survivalYears of ageMultivariate regression analysisBleeding eventsCardiogenic shockMajor bleedingOral anticoagulantsAdverse eventsElder patientsCardiac arrestLesion characteristics
2021
One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―
Sawano M, Kohsaka S, Ishii H, Numasawa Y, Yamaji K, Inohara T, Amano T, Ikari Y, Nakamura M. One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―. Circulation Journal 2021, 85: 1756-1767. PMID: 34162778, DOI: 10.1253/circj.cj-21-0098.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionST-elevation myocardial infarctionHeart failureHospital survivorsCoronary interventionIschemic strokeUnstable anginaMyocardial infarctionHigh riskAcute myocardial infarction populationNon-fatal ischemic strokeLate adverse cardiac eventsJapanese nationwide cohortJapanese nationwide registryNon-cardiac deathAcute heart failureAdverse cardiac eventsAcute coronary syndromeHeart failure eventsOne-year outcomesElevation myocardial infarctionSudden cardiac deathMyocardial infarction populationQuality of careACS patients
2020
Association of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study
Kuno T, Numasawa Y, Mikami T, Niimi N, Sawano M, Kodaira M, Suzuki M, Ueno K, Ueda I, Fukuda K, Kohsaka S. Association of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study. Heart And Vessels 2020, 36: 330-336. PMID: 33034713, DOI: 10.1007/s00380-020-01706-w.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPercutaneous coronary interventionRisk of AKIHemoglobin dropAKI incidenceKidney injuryCoronary interventionHemoglobin levelsProspective multi-center studySerum creatinine levelsMulti-center studyRelative decreaseConsecutive patientsCreatinine levelsIndependent predictorsRisk factorsHemoglobin changeHigh riskAbsolute decreaseLogistic regressionPatientsIncidenceHemoglobinInjuryDlIndependent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention
Kimura M, Kohno T, Sawano M, Heidenreich P, Ueda I, Takahashi T, Matsubara T, Ueno K, Hayashida K, Yuasa S, Ohki T, Fukuda K, Kohsaka S. Independent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention. Journal Of Cardiology 2020, 77: 41-47. PMID: 32888830, DOI: 10.1016/j.jjcc.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedCause of DeathFemaleHeart Disease Risk FactorsHeart FailureHospitalizationHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionPostoperative ComplicationsProportional Hazards ModelsRegistriesStrokeStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular systolic dysfunctionLeft ventricular ejection fractionMajor adverse cardiovascular eventsClinical heart failureNon-cardiac deathHeart failureLong-term outcomesHF hospitalizationIncidence of MACEAdverse long-term clinical outcomesLong-term clinical outcomesPercutaneous coronary intervention outcomesClinical HF symptomsMulticenter registry studyAdverse cardiovascular eventsCoronary artery bypassVentricular systolic dysfunctionAcute coronary syndromePercutaneous coronary interventionVentricular ejection fractionPost-procedural outcomesCause deathArtery bypassCardiovascular eventsCoronary syndromeIschemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Ikemura N, Ueno K, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment. JAMA Network Open 2020, 3: e202004. PMID: 32239221, PMCID: PMC7118520, DOI: 10.1001/jamanetworkopen.2020.2004.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAspirinBrain IschemiaCase-Control StudiesClopidogrelDeathDrug Therapy, CombinationFemaleHemorrhageHumansJapanMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrasugrel HydrochlorideRegistriesRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentStrokeConceptsLow-dose prasugrelPercutaneous coronary interventionPrimary ischemic eventsAcute coronary syndromeBleeding eventsIschemic eventsCoronary syndromeST-segment elevation myocardial infarctionAcute Coronary Syndrome AssociatedPropensity score-matched analysisHigh-bleeding riskStandard-dose clopidogrelChronic kidney diseaseElevation myocardial infarctionPresent cohort studyShort-term outcomesEast Asian patientsReal-world outcomesPrasugrel treatmentClopidogrel administrationP2Y12 inhibitorsBaseline characteristicsClopidogrel treatmentCohort studyCoronary intervention
2019
In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry
Tani H, Sawano M, Numasawa Y, Kobayashi Y, Suzuki M, Noma S, Shiraishi Y, Ueda I, Fukuda K, Kohsaka S. In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry. Journal Of Cardiology 2019, 75: 635-640. PMID: 31899113, DOI: 10.1016/j.jjcc.2019.11.006.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePercutaneous coronary interventionCardiogenic shockMortality rateACS patientsHospital mortalityCoronary syndromeHospital outcomesHigh riskLeft main coronary artery diseaseMain coronary artery diseasePresence of CSST-elevation myocardial infarctionPercutaneous coronary intervention registryContemporary risk modelsCoronary lesion characteristicsLeft main diseaseCoronary artery bypassHospital mortality rateDe novo patientsElevation myocardial infarctionCoronary artery diseaseCoronary Intervention RegistryShort-term outcomesKey clinical characteristicsOutcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
Kodaira M, Sawano M, Kuno T, Numasawa Y, Noma S, Suzuki M, Imaeda S, Ueda I, Fukuda K, Kohsaka S. Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study. PLOS ONE 2019, 14: e0223215. PMID: 31618228, PMCID: PMC6795465, DOI: 10.1371/journal.pone.0223215.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overCerebrovascular DisordersFemaleHospital MortalityHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPeripheral Vascular DiseasesPostoperative HemorrhageRadial ArteryRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeConceptsTransradial coronary interventionAcute coronary syndromePeripheral arterial diseaseCerebrovascular diseaseCoronary interventionVascular diseaseRetrospective multicenter cohort studyAcute coronary syndrome patientsPercutaneous coronary intervention registryMulticenter cohort studyCoronary syndrome patientsCoronary Intervention RegistryIncidence of deathCoronary syndromeCohort studyIntervention RegistryArterial diseaseAdverse outcomesRisk factorsPatient outcomesAccess siteSyndrome patientsHigh riskComplicationsPatientsReal-world use of intravascular ultrasound in Japan: a report from contemporary multicenter PCI registry
Kuno T, Numasawa Y, Sawano M, Abe T, Ueda I, Kodaira M, Suzuki M, Noma S, Nakamura I, Negishi K, Ishikawa S, Fukuda K, Kohsaka S. Real-world use of intravascular ultrasound in Japan: a report from contemporary multicenter PCI registry. Heart And Vessels 2019, 34: 1728-1739. PMID: 31129872, DOI: 10.1007/s00380-019-01427-9.Peer-Reviewed Original ResearchConceptsElective percutaneous coronary interventionPercutaneous coronary interventionEmergent percutaneous coronary interventionNon-IVUS groupPCI-related complicationsCoronary dissectionIntravascular ultrasoundIVUS usePCI registryMultivariate logistic regression analysisPlain old balloon angioplastyElective PCI patientsJapanese PCI registryMulticenter PCI registrySevere coronary dissectionMore comorbid conditionsClinical trial dataLogistic regression analysisLow event ratesIVUS groupPCI patientsCoronary interventionConsecutive patientsIndependent predictorsClinical outcomesNovel Approach for Visualizing Multiple Domains of Quality of Life Scales
Ikemura N, Kimura T, Sawano M, Fukuda K, Takatsuki S, Spertus J, Kohsaka S. Novel Approach for Visualizing Multiple Domains of Quality of Life Scales. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005573. PMID: 31092021, DOI: 10.1161/circoutcomes.119.005573.Peer-Reviewed Original ResearchComparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry)
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Kadota K, Shiode N, Tanaka N, Amano T, Uemura S, Akasaka T, Morino Y, Fujii K, Hikichi H, Kohsaka S, Ishii H, Tanabe K, Ozaki Y, Sumitsuji S, Iida O, Hara H, Takashima H, Shirai S, Nanasato M, Inohara T, Ueda Y, Numasawa Y, Noma S. Comparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry). Journal Of The American Heart Association 2019, 8: e011183. PMID: 30791799, PMCID: PMC6474917, DOI: 10.1161/jaha.118.011017.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeOlder patientsHospital mortalityElderly patientsCoronary interventionNationwide registryYounger patientsTransradial interventionStable coronary artery diseaseConclusion Older patientsJapanese nationwide registryProspective nationwide registryChronic kidney diseaseCoronary artery diseaseComparison of outcomesYears of ageCardiac tamponadeCardiogenic shockCoronary syndromeHospital deathHospital outcomesPeriprocedural complicationsArtery diseaseBlood transfusion
2018
Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention
Shoji S, Kohsaka S, Kumamaru H, Sawano M, Shiraishi Y, Ueda I, Noma S, Suzuki M, Numasawa Y, Hayashida K, Yuasa S, Miyata H, Fukuda K. Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention. Circulation Cardiovascular Interventions 2018, 11: e006761. PMID: 30545258, DOI: 10.1161/circinterventions.118.006761.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPeriprocedural strokeTransradial interventionTransfemoral interventionCoronary interventionAccess siteElective percutaneous coronary interventionPropensity score-matched analysisMultivariable logistic regression analysisOptimal access siteProspective multicenter databaseAcute kidney injuryAcute coronary syndromeChronic kidney diseaseLife-threatening complicationsPeripheral artery diseaseLogistic regression analysisCoronary syndromeHemorrhagic eventsKidney injuryPCI complicationsArtery diseaseMulticenter databaseStroke patientsKidney disease