2024
The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID
Krumholz H, Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li S, Herrin J, Coppi A, Holub J, Henriquez Y, Johnson M, Goddard T, Rocco E, Hummel A, Al Mouslmani M, Putrino D, Carr K, Carvajal-Gonzalez S, Charnas L, De Jesus M, Ziegler F, Iwasaki A. The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID. The American Journal Of Medicine 2024 PMID: 38735354, DOI: 10.1016/j.amjmed.2024.04.030.Peer-Reviewed Original ResearchLC trialPROMIS-29Participants' homesTargeting viral persistencePlacebo-controlled trialDouble-blind studyElectronic health recordsCore Outcome MeasuresLong COVIDEQ-5D-5LRepeated measures analysisEvidence-based treatmentsPhase 2Double-blindParticipant-centred approachStudy drugPrimary endpointSecondary endpointsCommunity-dwellingHealth recordsHealthcare utilizationContiguous US statesViral persistencePatient groupDrug treatment
2023
Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry
Kuno T, Ohata T, Nakamaru R, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry. Scientific Reports 2023, 13: 20318. PMID: 37985895, PMCID: PMC10662469, DOI: 10.1038/s41598-023-47444-7.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLong-term outcomesCoronary dissectionPrimary endpointCoronary perforationCoronary interventionHeart failurePrimary outcomeMultivariable Cox hazards regression modelIndex percutaneous coronary interventionCox hazard regression modelPoor long-term outcomesIatrogenic coronary dissectionJapanese multicenter registryMulticenter prospective registryCoronary artery bypassAcute coronary syndromeHeart failure readmissionContrast medium extravasationHazards regression modelsPersistent filling defectSignificant differencesHigh rateCause deathArtery bypass
2014
Prognostic Implication of Physical Signs of Congestion in Acute Heart Failure Patients and Its Association with Steady-State Biomarker Levels
Negi S, Sawano M, Kohsaka S, Inohara T, Shiraishi Y, Kohno T, Maekawa Y, Sano M, Yoshikawa T, Fukuda K. Prognostic Implication of Physical Signs of Congestion in Acute Heart Failure Patients and Its Association with Steady-State Biomarker Levels. PLOS ONE 2014, 9: e96325. PMID: 24802880, PMCID: PMC4011709, DOI: 10.1371/journal.pone.0096325.Peer-Reviewed Original ResearchConceptsJugular venous distensionAcute heart failurePulmonary ralesTime of dischargePhysical findingsReadmission ratesAHF patientsAcute heart failure patientsElevated troponin T levelsSingle-center university hospitalConsecutive AHF patientsElevated TnT levelsParoxysmal nocturnal dyspneaNon-ischemic etiologyTroponin T levelsHeart failure patientsNon-ischemic cardiomyopathyLong-term outcomesTime of admissionThird heart soundNocturnal dyspneaMean followPrimary endpointVenous distensionFailure patients