Featured Publications
Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry
Sawano M, Spertus J, Masoudi F, Rumsfeld J, Numasawa Y, Inohara T, Kennedy K, Ueda I, Miyata H, Fukuda K, Kohsaka S. Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry. American Heart Journal 2021, 235: 113-124. PMID: 33472053, DOI: 10.1016/j.ahj.2021.01.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransfemoral approachTransradial approachNational Cardiovascular Data Registry CathPCI RegistryVascular closure device usePercutaneous coronary intervention outcomesMultivariable logistic regression analysisClosure device useConsecutive PCI patientsJapanese multicenter registryAdjusted odds ratioLogistic regression analysisPCI patientsCathPCI RegistryCoronary interventionMulticenter registryBleeding rateJapanese patientsOdds ratioRisk scoreLower riskPatientsUS populationCathPCIJapanese population
2024
A Novel Risk Score for Major Bleeding in Japanese Patients with Non-Valvular Atrial Fibrillation: The J-RISK AF Study
Akao M, Tomita H, Nakai M, Kodani E, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Okamura T, Sasahara Y, Okumura K, Group O. A Novel Risk Score for Major Bleeding in Japanese Patients with Non-Valvular Atrial Fibrillation: The J-RISK AF Study. Journal Of Atherosclerosis And Thrombosis 2024, 31: 1591-1606. PMID: 38811233, PMCID: PMC11537787, DOI: 10.5551/jat.64842.Peer-Reviewed Original ResearchNon-valvular atrial fibrillationOral anticoagulantsRisk stratification systemJapanese patientsHAS-BLEDAtrial fibrillationNon-valvular atrial fibrillation patientsMultivariate Cox proportional hazards analysisConcomitant antiplatelet agentsAF studyCox proportional hazards analysisRisk scoreStratification systemBleeding risk stratificationFollow-up periodNovel risk scoreProportional hazards analysisRisk of ischemic strokeAF RegistryNon-valvularBleeding historyMajor bleedingRisk stratificationAntiplatelet agentsBleeding
2022
Impact of baseline blood pressure on adverse outcomes in Japanese patients with non-valvular atrial fibrillation: the J-RISK AF
Kodani E, Tomita H, Nakai M, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y, Okumura K, Group F. Impact of baseline blood pressure on adverse outcomes in Japanese patients with non-valvular atrial fibrillation: the J-RISK AF. European Heart Journal Open 2022, 2: oeac081. PMID: 36583077, PMCID: PMC9793850, DOI: 10.1093/ehjopen/oeac081.Peer-Reviewed Original ResearchSystolic baseline blood pressureBaseline blood pressureAtrial fibrillationMajor bleedingHazard ratioAF RegistryJapanese patientsCardiovascular deathIschemic strokeBlood pressureAdverse outcomesBaseline systolic BPNon-valvular AF patientsNon-valvular atrial fibrillationFushimi AF RegistryJ-RHYTHM RegistryIndependent risk factorBaseline BP valuesLarge-scale cohortCause deathAdverse eventsCardiovascular mortalityAF patientsPooled analysisRisk factorsUsefulness of echocardiographic parameters in predicting the incidence of ischemic stroke in Japanese patients with non-valvular atrial fibrillation
Tezuka Y, Akao M, Suzuki S, Yamashita T, Kodani E, Tsuda T, Hayashi K, Furusho H, Sawano M, Fukuda K, Nakai M, Sasahara Y, Miyamoto Y, Tomita H, Okumura K. Usefulness of echocardiographic parameters in predicting the incidence of ischemic stroke in Japanese patients with non-valvular atrial fibrillation. European Heart Journal 2022, 43: ehac544.548. DOI: 10.1093/eurheartj/ehac544.548.Peer-Reviewed Original ResearchIncidence of ISRelative wall thicknessPrescription of OACsCHA2DS2-VASc scoreIschemic strokeLV ejection fractionOral anticoagulantsAtrial fibrillationJapanese patientsNVAF patientsEchocardiographic parametersEjection fractionRisk factorsNon-valvular atrial fibrillation patientsHigher relative wall thicknessNon-valvular atrial fibrillationLV end-diastolic dimensionEcho parametersEnd-diastolic dimensionAtrial fibrillation patientsCo-existing diseasesKaplan-Meier analysisParasternal long-axis viewNovel risk scoreBackground Atrial fibrillation
2020
Association between bleeding avoidance and outcomes: Japanese coronary intervention registry report in collaboration with ACC-NCDR
Sawano M, Numasawa Y, Spertus J, Kennedy K, Inohara T, Miyata H, Fukuda K, Rumsfeld J, Masoudi F, Kohsaka S. Association between bleeding avoidance and outcomes: Japanese coronary intervention registry report in collaboration with ACC-NCDR. European Heart Journal 2020, 41: ehaa946.2512. DOI: 10.1093/ehjci/ehaa946.2512.Peer-Reviewed Original ResearchRadial accessBleeding rateJapanese patientsBAS useRisk scoreNational Cardiovascular Data Registry CathPCIClosure device useConsecutive Japanese patientsMultivariable logistic modelVascular closure deviceQuality improvement initiativesHigh-quality careFemoral accessRegistry reportsElective casesClosure deviceStudy populationAmerican CollegeEmergent casesACC-NCDRCathPCIQuality careAccess useObserved bleedingStudy periodAssociation of Second-Generation Drug-Eluting Stent Length With 2-Year Adverse Clinical Outcomes Among Japanese Patients With Ischemic Heart Disease
Ejiri K, Sawano M, Numasawa Y, Noma S, Ito H, Fukuda K, Kohsaka S. Association of Second-Generation Drug-Eluting Stent Length With 2-Year Adverse Clinical Outcomes Among Japanese Patients With Ischemic Heart Disease. JAMA Network Open 2020, 3: e2012546. PMID: 32756926, PMCID: PMC7407091, DOI: 10.1001/jamanetworkopen.2020.12546.Peer-Reviewed Original ResearchAdherence to antihypertensive medication and its predictors among non-elderly adults in Japan
Nishimura S, Kumamaru H, Shoji S, Sawano M, Kohsaka S, Miyata H. Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan. Hypertension Research 2020, 43: 705-714. PMID: 32313192, DOI: 10.1038/s41440-020-0440-2.Peer-Reviewed Original ResearchConceptsLow adherenceAntihypertensive medicationsAntihypertensive drugsJapanese patientsLarge administrative claims databaseAntihypertensive drug usersInitiation of angiotensinAdministrative claims databaseSuboptimal clinical outcomesProportion of daysNon-elderly adultsLogistic regression analysisHypertensive patientsThiazide diureticsClinical outcomesClaims databaseFemale sexHigh adherencePatientsEnzyme inhibitorsDrug usersYounger ageTargeted interventionsFacility characteristicsLarge hospitalsRisk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation
Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y. Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation. JAMA Network Open 2020, 3: e202881. PMID: 32293685, PMCID: PMC7160687, DOI: 10.1001/jamanetworkopen.2020.2881.Peer-Reviewed Original ResearchConceptsNonvalvular atrial fibrillationFushimi AF RegistryJ-RHYTHM RegistryRisk stratification schemesIschemic strokeAF RegistryBody mass indexRisk factorsAtrial fibrillationJapanese patientsPermanent AFPrevious strokeMass indexShinken DatabaseStratification schemesCox proportional hazards analysisLower body mass indexOral anticoagulant useIndependent risk factorProportional hazards analysisSignificant risk factorsIndividual patient dataValvular AFAnticoagulant useCohort studyPrediction of sudden cardiac death in Japanese heart failure patients: international validation of the Seattle Proportional Risk Model.
Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardas T, Levy W, Yoshikawa T. Prediction of sudden cardiac death in Japanese heart failure patients: international validation of the Seattle Proportional Risk Model. EP Europace 2020, 22: 588-597. PMID: 32155253, DOI: 10.1093/europace/euaa002.Peer-Reviewed Original ResearchConceptsSeattle Proportional Risk ModelSudden cardiac deathHF patientsProportional risk modelCardiac deathHeart failureIncidence of SCDJapanese heart failure patientsAcute HF patientsICD eligibility criteriaReduced ejection fractionHeart failure patientsHosmer-Lemeshow statisticHF registryAcute decompensationCumulative incidenceFailure patientsEjection fractionC-statisticJapanese RegistryJapanese patientsC-indexSCD predictionEligibility criteriaPatients
2019
Discrepancy between patient-reported quality of life and the prognostic assessment of Japanese patients hospitalized with acute heart failure
Shoji S, Shiraishi Y, Sawano M, Katsumata Y, Yuasa S, Kohno T, Fukuda K, Spertus J, Kohsaka S. Discrepancy between patient-reported quality of life and the prognostic assessment of Japanese patients hospitalized with acute heart failure. Heart And Vessels 2019, 34: 1464-1470. PMID: 30887105, DOI: 10.1007/s00380-019-01378-1.Peer-Reviewed Original ResearchConceptsClinical risk scorePatient-reported qualityLong-term prognosisHeart failureHHF patientsRisk scoreComposite outcomeAcute settingGWTG-HF risk scoreHospitalized HF patientsAcute heart failureChronic heart failurePrimary therapeutic targetHealth care providersFirst yearCause mortalityHF patientsHF readmissionPatient characteristicsIndependent predictorsAcute phasePrognostic indicatorJapanese patientsPrognostic assessmentCare providers