Featured Publications
Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry
Sawano M, Spertus J, Masoudi F, Rumsfeld J, Numasawa Y, Inohara T, Kennedy K, Ueda I, Miyata H, Fukuda K, Kohsaka S. Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry. American Heart Journal 2021, 235: 113-124. PMID: 33472053, DOI: 10.1016/j.ahj.2021.01.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransfemoral approachTransradial approachNational Cardiovascular Data Registry CathPCI RegistryVascular closure device usePercutaneous coronary intervention outcomesMultivariable logistic regression analysisClosure device useConsecutive PCI patientsJapanese multicenter registryAdjusted odds ratioLogistic regression analysisPCI patientsCathPCI RegistryCoronary interventionMulticenter registryBleeding rateJapanese patientsOdds ratioRisk scoreLower riskPatientsUS populationCathPCIJapanese population
2024
Cardiac arrest and post-discharge mortality in patients with myocardial infarction: A large-scale nationwide registry analysis
Ando H, Sawano M, Kohsaka S, Ishii H, Tajima A, Suzuki W, Kunimura A, Nakano Y, Kozuma K, Amano T. Cardiac arrest and post-discharge mortality in patients with myocardial infarction: A large-scale nationwide registry analysis. Resuscitation Plus 2024, 18: 100647. PMID: 38737095, PMCID: PMC11088348, DOI: 10.1016/j.resplu.2024.100647.Peer-Reviewed Original ResearchAcute myocardial infarctionPost-discharge mortalityCardiac arrestAcute myocardial infarction managementPercutaneous coronary interventionConcomitant cardiac arrestMyocardial infarctionPost-discharge outcomesRegistry of percutaneous coronary interventionsCoronary interventionLong-term mortalityNational registryOutcomes RegistryPost-discharge outcomes of patientsJ-PCIInterventionAnalysed dataComplication of acute myocardial infarctionAge groupsRegistry analysisMortalityShort-term outcomesOutcomes of patientsInfarctionMultivariate analysis
2023
Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry
Kuno T, Ohata T, Nakamaru R, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry. Scientific Reports 2023, 13: 20318. PMID: 37985895, PMCID: PMC10662469, DOI: 10.1038/s41598-023-47444-7.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLong-term outcomesCoronary dissectionPrimary endpointCoronary perforationCoronary interventionHeart failurePrimary outcomeMultivariable Cox hazards regression modelIndex percutaneous coronary interventionCox hazard regression modelPoor long-term outcomesIatrogenic coronary dissectionJapanese multicenter registryMulticenter prospective registryCoronary artery bypassAcute coronary syndromeHeart failure readmissionContrast medium extravasationHazards regression modelsPersistent filling defectSignificant differencesHigh rateCause deathArtery bypassOne‐year outcomes of patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy catheter: Insights from the J‐PCI OUTCOME registry
Numasawa Y, Sawano M, Ishii H, Kohsaka S, Kikuta Y, Matoba T, Amano T, Kozuma K, Investigators T. One‐year outcomes of patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy catheter: Insights from the J‐PCI OUTCOME registry. Catheterization And Cardiovascular Interventions 2023, 102: 1229-1237. PMID: 37943854, DOI: 10.1002/ccd.30895.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsDirectional coronary atherectomyPercutaneous coronary interventionStable coronary artery diseaseOne-year outcomesCoronary artery diseaseMajor bleedingCoronary interventionUnstable anginaArtery diseaseDCA groupContemporary real-world practiceDrug-coated balloon angioplastyOne-year clinical outcomesJapanese nationwide registryNonfatal major bleedingAdverse cardiovascular eventsCardiovascular deathCardiovascular eventsCause mortalityMidterm outcomesBaseline characteristicsCardiovascular mortalityCoronary atherectomyNationwide registryTransradial intervention in dialysis patients undergoing percutaneous coronary intervention: a Japanese nationwide registry study
Kuno T, Yamaji K, Aikawa T, Sawano M, Ando T, Numasawa Y, Wada H, Amano T, Kozuma K, Kohsaka S. Transradial intervention in dialysis patients undergoing percutaneous coronary intervention: a Japanese nationwide registry study. European Heart Journal Open 2023, 3: oead116. PMID: 38105921, PMCID: PMC10721448, DOI: 10.1093/ehjopen/oead116.Peer-Reviewed Original ResearchPercutaneous coronary interventionAccess site bleedingTransradial interventionHospital deathTransfemoral interventionPeriprocedural complicationsSite bleedingCoronary interventionDialysis patientsAccess siteLower riskNationwide registry studyChronic coronary syndromeHospital complicationsCoronary syndromeRegistry studySecondary outcomesPrimary outcomePatient populationBleeding rateRegistry dataComplicationsPatientsTRI groupDialysisGender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan
Kuno T, Miyamoto Y, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan. The American Journal Of Cardiology 2023, 206: 151-160. PMID: 37703680, DOI: 10.1016/j.amjcard.2023.08.106.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary end pointLong-term outcomesYounger patientsCause deathCoronary interventionOlder patientsMale patientsAcute coronary syndrome casesPrimary end point ratesLong-term outcome analysisST-elevation myocardial infarctionEnd pointUnderwent Percutaneous Coronary InterventionWorse long-term outcomesYoung womenCoronary artery bypassAcute coronary syndromeConsecutive young patientsYoung female patientProportion of smokingNoncardiac deathArtery bypassCoronary syndromeMulticenter registryIschemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry)
Tobe A, Sawano M, Kohsaka S, Ishii H, Tanaka A, Numasawa Y, Amano T, Nakamura M, Ikari Y, Murohara T. Ischemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry). The American Journal Of Cardiology 2023, 195: 37-44. PMID: 37004333, DOI: 10.1016/j.amjcard.2023.02.027.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePercutaneous coronary interventionPresence of CKDCKD stages 1Ischemic eventsAdjustment of covariatesHigh riskPCI registryCoronary interventionKidney diseaseNew-generation drug-eluting stent implantationDrug-eluting stent implantationUnderwent Percutaneous Coronary InterventionCKD stage 3Stage 1Bleeding eventsBleeding outcomesDialysis groupOral anticoagulantsCKD 3Renal functionStent implantationIncidence ratePatientsCare deliveryGenetic Backgrounds Associated With Stent Thrombosis A Pilot Study From a Percutaneous Coronary Intervention Registry
Shoji S, Sawano M, Inohara T, Hiraide T, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Genetic Backgrounds Associated With Stent Thrombosis A Pilot Study From a Percutaneous Coronary Intervention Registry. JACC Advances 2023, 2: 100172. PMID: 38939036, PMCID: PMC11198226, DOI: 10.1016/j.jacadv.2022.100172.Peer-Reviewed Original ResearchEarly stent thrombosisLST/VLSTPercutaneous coronary interventionStent thrombosisPolygenic risk scoresCoronary interventionMulticenter PCI registryLate stent thrombosisA Pilot StudyDifferent genetic predispositionPCI patientsPCI registrySignificant single nucleotide polymorphismsPathophysiologic characteristicsPatient populationFatal eventsRisk scoreGenetic predispositionVLSTThrombosisPatientsPilot studyRegistryRisk predictionSingle nucleotide polymorphisms
2022
Overview of in‐hospital outcomes in patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Amano T, Nakamura M, Ikari Y, Investigators J. Overview of in‐hospital outcomes in patients undergoing percutaneous coronary intervention with the revived directional coronary atherectomy. Catheterization And Cardiovascular Interventions 2022, 100: 51-58. PMID: 35592940, DOI: 10.1002/ccd.30233.Peer-Reviewed Original ResearchConceptsStable coronary artery diseaseCoronary artery diseaseHospital outcomesUnstable anginaArtery diseaseDCA groupContemporary real-world practiceDrug-coated balloon angioplastyPercutaneous coronary intervention registryHospital adverse outcomesLeft main trunkChronic kidney diseaseDirectional coronary atherectomyPercutaneous coronary interventionCoronary Intervention RegistryLow complication rateTotal contrast volumePreferred treatment strategyPeriprocedural complicationsArtery lesionsBaseline characteristicsComplication rateCoronary atherectomyCoronary interventionIntervention RegistryMachine learning models for prediction of adverse events after percutaneous coronary intervention
Niimi N, Shiraishi Y, Sawano M, Ikemura N, Inohara T, Ueda I, Fukuda K, Kohsaka S. Machine learning models for prediction of adverse events after percutaneous coronary intervention. Scientific Reports 2022, 12: 6262. PMID: 35428765, PMCID: PMC9012739, DOI: 10.1038/s41598-022-10346-1.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse eventsRisk scoreHospital mortalityCoronary interventionConsecutive coronary artery disease patientsCoronary artery disease patientsAdverse periprocedural eventsLow-risk patientsMajor adverse eventsGood discriminationMulticenter registryPeriprocedural eventsDisease patientsClinical decisionLogistic regressionSpecific interventionsRisk predictionOverall risk predictionPatientsScoresInterventionMortalityAdequate discriminationOutcomesOne-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry
Otowa K, Kohsaka S, Sawano M, Matsuura S, Chikata A, Maruyama M, Usuda K, Watanabe T, Ishii H, Amano T, Nakamura M, Ikari Y. One-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry. American Heart Journal 2022, 246: 105-116. PMID: 35016854, DOI: 10.1016/j.ahj.2022.01.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse cardiovascular eventsLong-term outcomesCardiovascular eventsNonagenarian patientsCardiovascular mortalityCoronary interventionOutcomes RegistryMajor adverse cardiovascular eventsCV death rateMajor bleeding eventsOne-year outcomesNationwide registration systemPatient-level dataLong-term survivalYears of ageMultivariate regression analysisBleeding eventsCardiogenic shockMajor bleedingOral anticoagulantsAdverse eventsElder patientsCardiac arrestLesion characteristics
2021
Evidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Noma S, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Evidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention. Journal Of The American Heart Association 2021, 10: e020047. PMID: 34310187, PMCID: PMC8475676, DOI: 10.1161/jaha.120.020047.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overClinical Decision-MakingContrast MediaDatabases, FactualEvidence-Based MedicineFemaleHumansIncidenceJapanKidneyKidney Function TestsMaleMiddle AgedPercutaneous Coronary InterventionProfessional Practice GapsProtective FactorsQuality ImprovementQuality Indicators, Health CareRadiography, InterventionalRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeConceptsAcute kidney injuryPercutaneous coronary interventionAKI risk scoreBaseline renal functionContrast volumeCoronary interventionRisk scoreAKI riskKidney injuryRenal functionAcute coronary syndrome presentationBackground Acute kidney injuryIntra-aortic balloon pumpMultivariable linear regression analysisContrast volume usagePreprocedural risk assessmentChronic kidney diseaseAvailable risk scoresCommon complicationBalloon pumpHeart failureSusceptible patientsOverall incidenceSyndrome presentationKidney diseaseOne-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―
Sawano M, Kohsaka S, Ishii H, Numasawa Y, Yamaji K, Inohara T, Amano T, Ikari Y, Nakamura M. One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―. Circulation Journal 2021, 85: 1756-1767. PMID: 34162778, DOI: 10.1253/circj.cj-21-0098.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionST-elevation myocardial infarctionHeart failureHospital survivorsCoronary interventionIschemic strokeUnstable anginaMyocardial infarctionHigh riskAcute myocardial infarction populationNon-fatal ischemic strokeLate adverse cardiac eventsJapanese nationwide cohortJapanese nationwide registryNon-cardiac deathAcute heart failureAdverse cardiac eventsAcute coronary syndromeHeart failure eventsOne-year outcomesElevation myocardial infarctionSudden cardiac deathMyocardial infarction populationQuality of careACS patientsFemale sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis
Kodaira M, Sawano M, Tanaka M, Kuno T, Numasawa Y, Ueda I, Fukuda K, Kohsaka S. Female sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis. Journal Of Cardiology 2021, 78: 431-438. PMID: 34172350, DOI: 10.1016/j.jjcc.2021.05.016.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeFine-Gray modelPrimary outcomeFemale sexPercutaneous coronary intervention patientsLower body mass indexEtiology of readmissionMulticenter PCI registryPrevious heart failureUnadjusted readmission ratesAdjusted hazard ratioHigh bleeding riskBody mass indexLong-term outcomesCox regression modelACS survivorsCumulative incidence functionMajor bleedingMore comorbiditiesBleeding riskCoronary syndromeIntervention patientsPCI registryCoronary intervention
2020
Association of the Hemoglobin to Serum Creatinine Ratio with In-Hospital Adverse Outcomes after Percutaneous Coronary Intervention among Non-Dialysis Patients: Insights from a Japanese Nationwide Registry (J-PCI Registry)
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Ikari Y. Association of the Hemoglobin to Serum Creatinine Ratio with In-Hospital Adverse Outcomes after Percutaneous Coronary Intervention among Non-Dialysis Patients: Insights from a Japanese Nationwide Registry (J-PCI Registry). Journal Of Clinical Medicine 2020, 9: 3612. PMID: 33182592, PMCID: PMC7696709, DOI: 10.3390/jcm9113612.Peer-Reviewed Original ResearchPercutaneous coronary interventionNon-dialysis patientsHospital adverse outcomesJapanese nationwide registryAdverse outcomesHospital mortalityCoronary interventionNationwide registryCr ratioComplex coronary artery diseaseIn-Hospital Adverse OutcomesHospital clinical outcomesSpline curve analysisHigher creatinine levelsCoronary artery diseaseSerum creatinine ratioBaseline hemoglobinMore comorbiditiesJapanese medical institutionsBaseline characteristicsCreatinine levelsRenal functionArtery diseaseCreatinine ratioLower hemoglobinAssociation of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study
Kuno T, Numasawa Y, Mikami T, Niimi N, Sawano M, Kodaira M, Suzuki M, Ueno K, Ueda I, Fukuda K, Kohsaka S. Association of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study. Heart And Vessels 2020, 36: 330-336. PMID: 33034713, DOI: 10.1007/s00380-020-01706-w.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPercutaneous coronary interventionRisk of AKIHemoglobin dropAKI incidenceKidney injuryCoronary interventionHemoglobin levelsProspective multi-center studySerum creatinine levelsMulti-center studyRelative decreaseConsecutive patientsCreatinine levelsIndependent predictorsRisk factorsHemoglobin changeHigh riskAbsolute decreaseLogistic regressionPatientsIncidenceHemoglobinInjuryDlGuideline-Based Medications for Older Adults Discharged after Percutaneous Coronary Intervention in a Suburban City of Japan: A Cohort Study Using Claims Data
Shimada K, Hamada S, Sawano M, Yamamoto H, Yoshie S, Iijima K, Miyata H. Guideline-Based Medications for Older Adults Discharged after Percutaneous Coronary Intervention in a Suburban City of Japan: A Cohort Study Using Claims Data. The Tohoku Journal Of Experimental Medicine 2020, 252: 143-152. PMID: 33028759, DOI: 10.1620/tjem.252.143.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsFemaleGeriatricsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInsurance Claim ReviewJapanMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPatient DischargePercutaneous Coronary InterventionPractice Guidelines as TopicRetrospective StudiesSecondary PreventionConceptsPercutaneous coronary interventionGuideline-based medicationsSecondary preventionΒ-blockersCohort studyCoronary interventionPrescription ratesClaims dataMultivariable logistic regression analysisOlder groupOlder adultsPrescription of antiplateletACEI/ARBRetrospective cohort studyAssociation of ageLogistic regression analysisCardiovascular eventsReceptor blockersAdjusted analysisBetter prognosisEnzyme inhibitorsMedicationsCommunity settingsStatinsPreventionApplicability and Eligibility of the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) for Patients who Underwent Revascularization with Percutaneous Coronary Intervention
Niimi N, Sawano M, Ikemura N, Nagai T, Nakano S, Shoji S, Shiraishi Y, Ueda I, Numasawa Y, Suzuki M, Noma S, Fukuda K, Kohsaka S. Applicability and Eligibility of the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) for Patients who Underwent Revascularization with Percutaneous Coronary Intervention. Journal Of Clinical Medicine 2020, 9: 2889. PMID: 32906673, PMCID: PMC7564619, DOI: 10.3390/jcm9092889.Peer-Reviewed Original ResearchPercutaneous coronary interventionNon-eligible patientsComparative Health EffectivenessSevere ischemiaEligible patientsBaseline characteristicsCoronary interventionRCT patientsStable ischemic heart disease patientsHealth effectivenessMajor adverse cardiac eventsIschemic heart disease patientsRole of revascularizationAdverse cardiac eventsEarly invasive strategyInvasive Approaches (ISCHEMIA) trialHeart disease patientsInternational studiesSIHD patientsMulticenter registryPCI patientsCardiac eventsISCHEMIA trialDisease patientsBaseline cohortAntithrombotic Strategy for Patients with Acute Coronary Syndrome: A Perspective from East Asia
Numasawa Y, Sawano M, Fukuoka R, Ejiri K, Kuno T, Shoji S, Kohsaka S. Antithrombotic Strategy for Patients with Acute Coronary Syndrome: A Perspective from East Asia. Journal Of Clinical Medicine 2020, 9: 1963. PMID: 32585929, PMCID: PMC7356748, DOI: 10.3390/jcm9061963.Peer-Reviewed Original ResearchAcute coronary syndromeDual antiplatelet therapyComposite ischemic eventsNovel P2Y12 inhibitorsAntithrombotic strategiesP2Y12 inhibitorsCoronary syndromeIschemic eventsWestern patientsTreatment platelet reactivityUse of clopidogrelPercutaneous coronary interventionCurrent clinical guidelinesStandard of careEast Asian patientsBorderline statistical differenceAntiplatelet therapyAntithrombotic therapyCoronary interventionClinical outcomesPlatelet reactivityAsian patientsHemorrhagic diathesisClinical guidelinesClinical studiesIschemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Ikemura N, Ueno K, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment. JAMA Network Open 2020, 3: e202004. PMID: 32239221, PMCID: PMC7118520, DOI: 10.1001/jamanetworkopen.2020.2004.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAspirinBrain IschemiaCase-Control StudiesClopidogrelDeathDrug Therapy, CombinationFemaleHemorrhageHumansJapanMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrasugrel HydrochlorideRegistriesRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentStrokeConceptsLow-dose prasugrelPercutaneous coronary interventionPrimary ischemic eventsAcute coronary syndromeBleeding eventsIschemic eventsCoronary syndromeST-segment elevation myocardial infarctionAcute Coronary Syndrome AssociatedPropensity score-matched analysisHigh-bleeding riskStandard-dose clopidogrelChronic kidney diseaseElevation myocardial infarctionPresent cohort studyShort-term outcomesEast Asian patientsReal-world outcomesPrasugrel treatmentClopidogrel administrationP2Y12 inhibitorsBaseline characteristicsClopidogrel treatmentCohort studyCoronary intervention