2024
A Novel Risk Score for Major Bleeding in Japanese Patients with Non-Valvular Atrial Fibrillation: The J-RISK AF Study
Akao M, Tomita H, Nakai M, Kodani E, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Okamura T, Sasahara Y, Okumura K, Group O. A Novel Risk Score for Major Bleeding in Japanese Patients with Non-Valvular Atrial Fibrillation: The J-RISK AF Study. Journal Of Atherosclerosis And Thrombosis 2024, 31: 1591-1606. PMID: 38811233, PMCID: PMC11537787, DOI: 10.5551/jat.64842.Peer-Reviewed Original ResearchNon-valvular atrial fibrillationOral anticoagulantsRisk stratification systemJapanese patientsHAS-BLEDAtrial fibrillationNon-valvular atrial fibrillation patientsMultivariate Cox proportional hazards analysisConcomitant antiplatelet agentsAF studyCox proportional hazards analysisRisk scoreStratification systemBleeding risk stratificationFollow-up periodNovel risk scoreProportional hazards analysisRisk of ischemic strokeAF RegistryNon-valvularBleeding historyMajor bleedingRisk stratificationAntiplatelet agentsBleeding
2022
Impact of baseline blood pressure on adverse outcomes in Japanese patients with non-valvular atrial fibrillation: the J-RISK AF
Kodani E, Tomita H, Nakai M, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y, Okumura K, Group F. Impact of baseline blood pressure on adverse outcomes in Japanese patients with non-valvular atrial fibrillation: the J-RISK AF. European Heart Journal Open 2022, 2: oeac081. PMID: 36583077, PMCID: PMC9793850, DOI: 10.1093/ehjopen/oeac081.Peer-Reviewed Original ResearchSystolic baseline blood pressureBaseline blood pressureAtrial fibrillationMajor bleedingHazard ratioAF RegistryJapanese patientsCardiovascular deathIschemic strokeBlood pressureAdverse outcomesBaseline systolic BPNon-valvular AF patientsNon-valvular atrial fibrillationFushimi AF RegistryJ-RHYTHM RegistryIndependent risk factorBaseline BP valuesLarge-scale cohortCause deathAdverse eventsCardiovascular mortalityAF patientsPooled analysisRisk factorsUsefulness of echocardiographic parameters in predicting the incidence of ischemic stroke in Japanese patients with non-valvular atrial fibrillation
Tezuka Y, Akao M, Suzuki S, Yamashita T, Kodani E, Tsuda T, Hayashi K, Furusho H, Sawano M, Fukuda K, Nakai M, Sasahara Y, Miyamoto Y, Tomita H, Okumura K. Usefulness of echocardiographic parameters in predicting the incidence of ischemic stroke in Japanese patients with non-valvular atrial fibrillation. European Heart Journal 2022, 43: ehac544.548. DOI: 10.1093/eurheartj/ehac544.548.Peer-Reviewed Original ResearchIncidence of ISRelative wall thicknessPrescription of OACsCHA2DS2-VASc scoreIschemic strokeLV ejection fractionOral anticoagulantsAtrial fibrillationJapanese patientsNVAF patientsEchocardiographic parametersEjection fractionRisk factorsNon-valvular atrial fibrillation patientsHigher relative wall thicknessNon-valvular atrial fibrillationLV end-diastolic dimensionEcho parametersEnd-diastolic dimensionAtrial fibrillation patientsCo-existing diseasesKaplan-Meier analysisParasternal long-axis viewNovel risk scoreBackground Atrial fibrillation
2020
Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation
Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y. Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation. JAMA Network Open 2020, 3: e202881. PMID: 32293685, PMCID: PMC7160687, DOI: 10.1001/jamanetworkopen.2020.2881.Peer-Reviewed Original ResearchConceptsNonvalvular atrial fibrillationFushimi AF RegistryJ-RHYTHM RegistryRisk stratification schemesIschemic strokeAF RegistryBody mass indexRisk factorsAtrial fibrillationJapanese patientsPermanent AFPrevious strokeMass indexShinken DatabaseStratification schemesCox proportional hazards analysisLower body mass indexOral anticoagulant useIndependent risk factorProportional hazards analysisSignificant risk factorsIndividual patient dataValvular AFAnticoagulant useCohort study