2024
Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis?
Jacob-Nascimento L, Portilho M, Anjos R, Moreira P, Stauber C, Weaver S, Kitron U, Reis M, Ribeiro G. Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis? Viruses 2024, 16: 235. PMID: 38400011, PMCID: PMC10891727, DOI: 10.3390/v16020235.Peer-Reviewed Original ResearchConceptsChikungunya virus infectionAcute-phase seraOral fluidChikungunya virusIgM seroconversionChikungunya virus diagnosisUrine samplesAcute febrile illnessConvalescent-phase seraAcute chikungunyaChikungunya patientsChikungunya virus RNADisease courseFebrile illnessPaired seraRT-qPCRAcute phaseIgM detectionConvalescent-phasePatientsControl group samplesSerumUrineCHIKV transmissionIgM
2020
Changes in the dynamics of dengue incidence in South and Central America are possibly due to cross‐population immunity after Zika virus epidemics
Mugabe V, Borja L, Cardoso C, Weaver S, Reis M, Kitron U, Ribeiro G. Changes in the dynamics of dengue incidence in South and Central America are possibly due to cross‐population immunity after Zika virus epidemics. Tropical Medicine And International Health 2020, 26: 272-280. PMID: 33190402, DOI: 10.1111/tmi.13526.Peer-Reviewed Original ResearchConceptsDengue casesLaboratory-confirmed dengue casesDENV vaccine developmentSignificant public health implicationsDengue virus infectionDengue incidenceLong-term surveillance studyCross-species immunityPublic health implicationsIncidence of dengueVirus immunityVirus infectionEpidemiological dataSurveillance studyDengue feverZika virusDisease severityVaccine developmentIncidenceZika epidemicAnnual dengue incidenceZika outbreakHealth implicationsImmunityOverall rate
2019
Evaluation of two commercially available chikungunya virus IgM enzyme-linked immunoassays (ELISA) in a setting of concomitant transmission of chikungunya, dengue and Zika viruses
Kikuti M, Tauro L, Moreira P, Nascimento L, Portilho M, Soares G, Weaver S, Reis M, Kitron U, Ribeiro G. Evaluation of two commercially available chikungunya virus IgM enzyme-linked immunoassays (ELISA) in a setting of concomitant transmission of chikungunya, dengue and Zika viruses. International Journal Of Infectious Diseases 2019, 91: 38-43. PMID: 31704226, DOI: 10.1016/j.ijid.2019.11.001.Peer-Reviewed Original ResearchConceptsConvalescent samplesIgM enzymeRT-PCRZika virus transmissionNegative patientsCHIKV infectionAcute samplesZIKV casesConvalescent seraSurveillance studyCHIKV transmissionZika virusCHIKV casesDiagnostic performanceLow specificityVirus transmissionEquivocal resultsTest sensitivitySerumELISA specificityPatientsHigh rateDengueConcomitant transmissionMore equivocal resultsAccuracy of the SD BIOLINE Dengue Duo for rapid point-of-care diagnosis of dengue
Kikuti M, Cruz J, Rodrigues M, Tavares A, Paploski I, Silva M, Santana P, Tauro L, Silva G, Campos G, Araújo J, Kitron U, Reis M, Ribeiro G. Accuracy of the SD BIOLINE Dengue Duo for rapid point-of-care diagnosis of dengue. PLOS ONE 2019, 14: e0213301. PMID: 30840708, PMCID: PMC6402663, DOI: 10.1371/journal.pone.0213301.Peer-Reviewed Original ResearchConceptsRapid diagnosis testsNon-dengue febrile patientsFebrile patientsHealthy controlsBlood donorsLaboratory-confirmed dengue casesSD BIOLINE Dengue DuoSecondary DENV infectionDengue virus antigenAcute-phase seraDengue diagnostic testsRepresentative serum samplesDengue-endemic regionsDengue-endemic areasSample of casesDENV antibodiesDENV infectionNS1 ELISAPrimary infectionDengue diagnosisMedical treatment decisionsTreatment decisionsVirus antigenRDT accuracyRDT sensitivity
2001
Referral pattern of leptospirosis cases during a large urban epidemic of dengue.
Flannery B, Pereira MM, Velloso L de F, Carvalho C de C, De Codes LG, Orrico G de S, Dourado CM, Riley LW, Reis MG, Ko AI. Referral pattern of leptospirosis cases during a large urban epidemic of dengue. American Journal Of Tropical Medicine And Hygiene 2001, 65: 657-63. PMID: 11716133, DOI: 10.4269/ajtmh.2001.65.657.Peer-Reviewed Original ResearchConceptsInfectious diseases reference hospitalFirst medical evaluationLarge urban epidemicDays of illnessInfectious Diseases HospitalIntensive care unitOnset of illnessCases of leptospirosisDiagnosis of dengueDiseases HospitalCare unitInitial diagnosisReference hospitalReferral patternsAmbulatory clinicsLeptospirosis epidemicMedical evaluationConcurrent epidemicsDengue diagnosisDiagnostic confusionUrban epidemicEarly symptomsHigh mortalityLeptospirosis casesLeptospirosis
1999
Urban epidemic of severe leptospirosis in Brazil
Ko A, Reis M, Dourado C, Johnson W, Riley L, Group S. Urban epidemic of severe leptospirosis in Brazil. The Lancet 1999, 354: 820-825. PMID: 10485724, DOI: 10.1016/s0140-6736(99)80012-9.Peer-Reviewed Original ResearchConceptsDengue feverInfectious disease referral hospitalAggressive supportive careEpidemic of leptospirosisStrong independent predictorPositive blood culturesLarge urban outbreaksIdentification of leptospiresRenal insufficiencyRespiratory insufficiencySevere leptospirosisSupportive careIndependent predictorsReferral hospitalOutpatient clinicSevere anemiaSevere manifestationsActive surveillanceMental statusRisk factorsBlood culturesDiagnostic confusionUrban epidemicMicroagglutination testUrban outbreaks