2023
Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study
Pieri O, Bezerra F, Coelho P, Enk M, Favre T, Graeff-Teixeira C, Oliveira R, Reis M, Andrade L, Beck L, Favero V, Fialho T, Guimarães R, Oliveira B, Pascoal V, Pinheiro M, Santos R, Silva L, Siqueira I, Souza R, Katz N. Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0238-2022. PMID: 36700600, PMCID: PMC9870275, DOI: 10.1590/0037-8682-0238-2022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, HelminthBrazilFecesHumansPoint-of-Care SystemsPrevalenceSchistosoma mansoniSchistosomiasis mansoniSensitivity and SpecificityConceptsCathodic antigenKato-KatzUrine-based pointSchistosomiasis mansoni infectionDifferent prevalence estimatesCare diagnostic testsSchistosomiasis elimination programmesWorld Health OrganizationMansoni infectionMulticenter studyStool samplesUrine pointPrevalence estimatesS. mansoniElimination programInfection statusDiagnostic testsHealth OrganizationUrine samplesHelmintexAntigenInfectionPrevalenceMansoniCare
2022
Evidence for local transmission and maintenance of schistosomiasis in an urban neighbourhood in Northeast Brazil
Chaves C, Sabino‐Santos G, Cedraz F, Santos‐Muccillo P, Filho J, Zanardi V, Moretto V, Santos A, Simões F, Barbosa L, Silva L, Reis M, Blanton R. Evidence for local transmission and maintenance of schistosomiasis in an urban neighbourhood in Northeast Brazil. Transboundary And Emerging Diseases 2022, 69: 3153-3159. PMID: 36057790, PMCID: PMC11013574, DOI: 10.1111/tbed.14692.Peer-Reviewed Original ResearchConceptsLocal transmissionSchistosoma mansoni infectionRural-urban migrationImportant demographic shiftPatterns of urbanizationUrban schistosomiasisMansoni infectionEpidemiological dataUrban neighborhoodsDemographic shiftsSchistosomiasisLocal transmission cyclesRural areasTransmission cycleUrban populationMetropolitan areaSame cityNeighborhoodUrbanizationCryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
Long J, Taylor S, Barbosa L, Silva L, Reis M, Blanton R. Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses. Scientific Reports 2022, 12: 1059. PMID: 35058485, PMCID: PMC8776789, DOI: 10.1038/s41598-022-04776-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrazilCluster AnalysisGenetics, PopulationHost-Parasite InteractionsHumansMicrosatellite RepeatsSchistosoma mansoniSchistosomiasis mansoni
2019
Prevalence of Infection of Biomphalaria glabrata by Schistosoma mansoni and the risk of urban Schistosomiasis mansoni in Salvador, Bahia, Brazil
Zanardi V, Barbosa L, Simões F, Thiengo S, Blanton R, Ribeiro Junior G, Silva L, Reis M. Prevalence of Infection of Biomphalaria glabrata by Schistosoma mansoni and the risk of urban Schistosomiasis mansoni in Salvador, Bahia, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2019, 52: e20190171. PMID: 31508782, DOI: 10.1590/0037-8682-0171-2019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomphalariaDisease VectorsHumansReal-Time Polymerase Chain ReactionRNA, Ribosomal, 18SSchistosoma mansoniSchistosomiasis mansoniUrban PopulationConceptsMansoni infectionS. mansoniSubunit-specific primersSchistosoma mansoni infectionS. mansoni infectionB. glabrataS. mansoni prevalenceCercarial sheddingReal-time polymerase chain reactionPublic health planningTime polymerase chain reactionPrevalence of infectionS. mansoni DNABiomphalaria glabrataSchistosomiasis mansoniPolymerase chain reactionHigh prevalenceHealth planningSchistosoma mansoniInfectionPrevalenceIncidence of schistosomiasisMansoniSchistosomiasis transmissionChain reaction
2007
Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens
Reis E, Azevedo T, McBride A, Harn D, Reis M. Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens. Scandinavian Journal Of Immunology 2007, 66: 662-670. PMID: 18021364, DOI: 10.1111/j.1365-3083.2007.02024.x.Peer-Reviewed Original ResearchConceptsSchistosoma mansoni soluble egg antigenNaïve human peripheral blood mononuclear cellsSoluble egg antigenIL-10Egg antigenIL-5T cellsT helper cell responsesHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsDonor dendritic cellsTh2-type responseTh2-like responseBlood mononuclear cellsPronounced CD4Dendritic cellsIL-12p40Immune suppressionIL-6Mononuclear cellsCytokine secretionDonor responsesIFN-gammaCD4Day 7
2004
Childhood stunting in Northeast Brazil: the role of Schistosoma mansoni infection and inadequate dietary intake
Assis A, Prado M, Barreto M, Reis M, Conceição Pinheiro S, Parraga I, Blanton R. Childhood stunting in Northeast Brazil: the role of Schistosoma mansoni infection and inadequate dietary intake. European Journal Of Clinical Nutrition 2004, 58: 1022-1029. PMID: 15220944, DOI: 10.1038/sj.ejcn.1601926.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnimalsBody HeightBrazilChildChild DevelopmentChild Nutritional Physiological PhenomenaCross-Sectional StudiesDietDietary CarbohydratesDietary FatsDietary ProteinsEnergy IntakeFecesFemaleGrowth DisordersHumansIntestinal Diseases, ParasiticLogistic ModelsMaleSchistosomiasis mansoniConceptsSchistosoma mansoni infectionS. mansoni infectionInadequate dietary intakeMansoni infectionDietary intakeS. mansoniHeavy S. mansoni infectionS. mansoni endemic areasDevelopment of stuntingRisk of stuntingCross-sectional studyUninfected childrenNutritional interventionDietary measuresInadequate intakeCarbohydrate intakeStool samplesHigh riskMedian proteinEndemic areasParasitic infectionsCaloric consumptionChildhood stuntingAge groupsAdequate diet
1998
Schistosoma mansoni infection and nutritional status in schoolchildren: a randomized, double-blind trial in northeastern Brazil 1 2 3
Assis A, Barreto M, Prado M, Reis M, Parraga I, Blanton R. Schistosoma mansoni infection and nutritional status in schoolchildren: a randomized, double-blind trial in northeastern Brazil 1 2 3. American Journal Of Clinical Nutrition 1998, 68: 1247-1253. PMID: 9846854, DOI: 10.1093/ajcn/68.6.1247.Peer-Reviewed Original ResearchConceptsBody mass indexNutritional statusMidarm circumferenceMansoni infectionMass indexSchistosome infectionChronic S. mansoni infectionDouble-blind trialDouble-blind fashionSchistosoma mansoni infectionS. mansoni infectionTriceps skinfold thicknessArm muscle areaPlacebo groupBrazilian schoolchildrenAnthropometric measurementsAnthropometric measuresSkinfold thicknessRate of improvementUntreated boysInfectionMuscle areaSignificant differencesSignificant increaseShort-term growth
1996
Gender differences in growth of school-aged children with schistosomiasis and geohelminth infection.
Parraga I, Assis A, Prado M, Barreto M, Reis M, King C, Blanton R. Gender differences in growth of school-aged children with schistosomiasis and geohelminth infection. American Journal Of Tropical Medicine And Hygiene 1996, 55: 150-6. PMID: 8780452, DOI: 10.4269/ajtmh.1996.55.150.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnalysis of VarianceAnthropometryAscariasisBody CompositionBrazilCase-Control StudiesChildDouble-Blind MethodFecesFemaleGrowth DisordersHumansMaleNutrition DisordersNutritional StatusParasite Egg CountProspective StudiesSchistosomiasis mansoniSex CharacteristicsSocioeconomic FactorsTrichuriasisConceptsUpper arm circumferenceTriceps skinfoldS. mansoniS. mansoni-infected childrenMid-upper arm circumferenceModerate-intensity infectionDevelopment of malnutritionEffect of treatmentSubscapular skinfold measurementsInfected boysInfected childrenArm circumferenceGeohelminth infectionsSchool-aged childrenIntensity of infectionBrazilian schoolchildrenAnthropometric measurementsChronic malnutritionIntensity infectionsControl childrenGrowth retardationGrowth deficitsSchistosoma mansoniSkinfold measurementsInfection
1994
Failure of schistosomiasis to significantly decrease testosterone levels in Brazilian men.
Skelly P, Secor W, Reis M, Ramos E, Carmo T, Peixoto E, Harn D. Failure of schistosomiasis to significantly decrease testosterone levels in Brazilian men. American Journal Of Tropical Medicine And Hygiene 1994, 51: 40-4. PMID: 8059914, DOI: 10.4269/ajtmh.1994.51.40.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsBrazilFecesHumansLeast-Squares AnalysisMaleParasite Egg CountRegression AnalysisSchistosomiasis mansoniTestosteroneConceptsTestosterone levelsSevere hepatosplenic diseaseSchistosoma mansoni infectionSerum testosterone levelsUsual side effectsYears of ageHepatosplenic diseaseEffect of ageMansoni infectionIntestinal schistosomiasisSide effectsNormal rangeHuman schistosomiasisBrazilian menHost castrationSchistosomiasisParasite loadBrazilian malesHuman malesCastrationAgeNegative correlationMalesVertebrate hostsLevels
1987
Functional significance of periovular granuloma in schistosomiasis.
Reis M, Andrade Z. Functional significance of periovular granuloma in schistosomiasis. Brazilian Journal Of Medical And Biological Research 1987, 20: 55-62. PMID: 3120841.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGranulomaIntestinesLiverLungMiceParasite Egg CountSchistosoma mansoniSchistosomiasis mansoniSchistosomicidesConceptsPeriovular granulomasSchistosoma mansoni cercariaeCurative chemotherapyLate infectionMansoni cercariaeGranulomasPresent findingsSchistosomiasisDifferent organsHost tissuesFunctional significanceTissuePrevious studiesChemotherapyDifferent morphological typesViable eggsInfectionMiceSecretionWeeks
1986
Stage and species specificity of antigens encoded by two geographic strains of Schistosoma mansoni mRNA.
Blanton R, Horowitz S, Reis M, Rottman F, Andrade Z, Mahmoud A. Stage and species specificity of antigens encoded by two geographic strains of Schistosoma mansoni mRNA. Journal Of Parasitology 1986, 72: 445-53. PMID: 3091803, DOI: 10.2307/3281685.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, HelminthBrazilCross ReactionsHumansMiceMice, Inbred C57BLMolecular WeightProtein BiosynthesisPuerto RicoRNA, MessengerSchistosoma haematobiumSchistosoma japonicumSchistosoma mansoniSchistosomiasis haematobiaSchistosomiasis japonicaSchistosomiasis mansoniSpecies SpecificityConceptsS. mansoniImmune human seraAntigen of MrGroup of antigensAdult worm mRNAAntigenic poolSchistosome infectionIntensity of infectionSchistosoma haematobiumIndividual seraAntigenAntigenic specificityAntigenic differencesSerumSchistosoma japonicumCross-reactive proteinEgg countsBrazilian parasitesInfectionMansoniMolecular weight proteinsHuman serumDifferent geographic strainsSpecies specificityHigh molecular weight proteins