2023
Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study
Pieri O, Bezerra F, Coelho P, Enk M, Favre T, Graeff-Teixeira C, Oliveira R, Reis M, Andrade L, Beck L, Favero V, Fialho T, Guimarães R, Oliveira B, Pascoal V, Pinheiro M, Santos R, Silva L, Siqueira I, Souza R, Katz N. Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0238-2022. PMID: 36700600, PMCID: PMC9870275, DOI: 10.1590/0037-8682-0238-2022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, HelminthBrazilFecesHumansPoint-of-Care SystemsPrevalenceSchistosoma mansoniSchistosomiasis mansoniSensitivity and SpecificityConceptsCathodic antigenKato-KatzUrine-based pointSchistosomiasis mansoni infectionDifferent prevalence estimatesCare diagnostic testsSchistosomiasis elimination programmesWorld Health OrganizationMansoni infectionMulticenter studyStool samplesUrine pointPrevalence estimatesS. mansoniElimination programInfection statusDiagnostic testsHealth OrganizationUrine samplesHelmintexAntigenInfectionPrevalenceMansoniCare
2022
Evidence for local transmission and maintenance of schistosomiasis in an urban neighbourhood in Northeast Brazil
Chaves C, Sabino‐Santos G, Cedraz F, Santos‐Muccillo P, Filho J, Zanardi V, Moretto V, Santos A, Simões F, Barbosa L, Silva L, Reis M, Blanton R. Evidence for local transmission and maintenance of schistosomiasis in an urban neighbourhood in Northeast Brazil. Transboundary And Emerging Diseases 2022, 69: 3153-3159. PMID: 36057790, PMCID: PMC11013574, DOI: 10.1111/tbed.14692.Peer-Reviewed Original ResearchConceptsLocal transmissionSchistosoma mansoni infectionRural-urban migrationImportant demographic shiftPatterns of urbanizationUrban schistosomiasisMansoni infectionEpidemiological dataUrban neighborhoodsDemographic shiftsSchistosomiasisLocal transmission cyclesRural areasTransmission cycleUrban populationMetropolitan areaSame cityNeighborhoodUrbanizationCryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses
Long J, Taylor S, Barbosa L, Silva L, Reis M, Blanton R. Cryptic population structure and transmission dynamics uncovered for Schistosoma mansoni populations by genetic analyses. Scientific Reports 2022, 12: 1059. PMID: 35058485, PMCID: PMC8776789, DOI: 10.1038/s41598-022-04776-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrazilCluster AnalysisGenetics, PopulationHost-Parasite InteractionsHumansMicrosatellite RepeatsSchistosoma mansoniSchistosomiasis mansoni
2021
A Schistosoma mansoni tri- and tetramer microsatellite catalog for genetic population diversity and differentiation
Kovach J, Long J, Barbosa L, Moura A, Silva L, Reis M, Blanton R. A Schistosoma mansoni tri- and tetramer microsatellite catalog for genetic population diversity and differentiation. International Journal For Parasitology 2021, 51: 1007-1014. PMID: 34022195, DOI: 10.1016/j.ijpara.2021.04.002.Peer-Reviewed Original Research
2019
Prevalence of Infection of Biomphalaria glabrata by Schistosoma mansoni and the risk of urban Schistosomiasis mansoni in Salvador, Bahia, Brazil
Zanardi V, Barbosa L, Simões F, Thiengo S, Blanton R, Ribeiro Junior G, Silva L, Reis M. Prevalence of Infection of Biomphalaria glabrata by Schistosoma mansoni and the risk of urban Schistosomiasis mansoni in Salvador, Bahia, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2019, 52: e20190171. PMID: 31508782, DOI: 10.1590/0037-8682-0171-2019.Peer-Reviewed Original ResearchConceptsMansoni infectionS. mansoniSubunit-specific primersSchistosoma mansoni infectionS. mansoni infectionB. glabrataS. mansoni prevalenceCercarial sheddingReal-time polymerase chain reactionPublic health planningTime polymerase chain reactionPrevalence of infectionS. mansoni DNABiomphalaria glabrataSchistosomiasis mansoniPolymerase chain reactionHigh prevalenceHealth planningSchistosoma mansoniInfectionPrevalenceIncidence of schistosomiasisMansoniSchistosomiasis transmissionChain reaction
2008
Schistosoma mansoni Triose Phosphate Isomerase Peptide MAP4 is Able to Trigger Naïve Donor Immune Response Towards a Type‐1 Cytokine Profile
Reis E, Carmo T, Athanazio R, Reis M, Harn D. Schistosoma mansoni Triose Phosphate Isomerase Peptide MAP4 is Able to Trigger Naïve Donor Immune Response Towards a Type‐1 Cytokine Profile. Scandinavian Journal Of Immunology 2008, 68: 169-176. PMID: 18565118, DOI: 10.1111/j.1365-3083.2008.02131.x.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsSchistosoma mansoni soluble egg antigenDendritic cellsCytokine productionAutologous peripheral blood mononuclear cellsType 1 cytokine profileMonocyte-derived dendritic cellsDonor dendritic cellsDonor immune responsesTh1-type responseT cell subsetsBlood mononuclear cellsIFN-gamma productionT cell epitopesMultiple antigen peptideMajor cell populationRecall stimulationCytokine profileIL-10Egg antigenMononuclear cellsT cellsImmune responseIFN-gammaMouse model
2007
Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens
Reis E, Azevedo T, McBride A, Harn D, Reis M. Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens. Scandinavian Journal Of Immunology 2007, 66: 662-670. PMID: 18021364, DOI: 10.1111/j.1365-3083.2007.02024.x.Peer-Reviewed Original ResearchConceptsSchistosoma mansoni soluble egg antigenNaïve human peripheral blood mononuclear cellsSoluble egg antigenIL-10Egg antigenIL-5T cellsT helper cell responsesHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsDonor dendritic cellsTh2-type responseTh2-like responseBlood mononuclear cellsPronounced CD4Dendritic cellsIL-12p40Immune suppressionIL-6Mononuclear cellsCytokine secretionDonor responsesIFN-gammaCD4Day 7
2000
Lower Hookworm Incidence, Prevalence, and Intensity of Infection in Children with a Bacillus Calmette-Guérin Vaccination Scar
Barreto M, Rodrigues L, Silva R, Assis A, Reis M, Santos C, Blanton R. Lower Hookworm Incidence, Prevalence, and Intensity of Infection in Children with a Bacillus Calmette-Guérin Vaccination Scar. The Journal Of Infectious Diseases 2000, 182: 1800-1803. PMID: 11069259, DOI: 10.1086/317627.Peer-Reviewed Original ResearchConceptsBCG vaccination scarBacillus Calmette-GuérinVaccination scarIntensity of infectionBacillus Calmette-Guérin (BCG) vaccination scarHuman immunodeficiency virus-infected adultsHuman immunological responsesOngoing prospective studyVaccination protectionIncidence ratiosProspective studyAdjusted prevalenceHookworm infectionCalmette-GuérinTrichuris trichiuraImmunological responseCommon vaccinesImmune systemHookworm prevalenceDifferent helminthsLogistic regressionPrevalenceSchistosoma mansoniIncidenceInfection
1989
Localization and pattern of expression of a female specific mRNA in Schistosoma mansoni
Reis M, Kuhns J, Blanton R, Davis A. Localization and pattern of expression of a female specific mRNA in Schistosoma mansoni. Molecular And Biochemical Parasitology 1989, 32: 113-119. PMID: 2927441, DOI: 10.1016/0166-6851(89)90062-5.Peer-Reviewed Original ResearchConceptsSex-specific gene expressionFemale-specific mRNAOpen reading frameFunction of eggsPattern of expressionMature female wormsNucleotide mRNACDNA sequenceReading frameGene expressionSpecific mRNAsFemale wormsFs800Central stretchAmino acidsVitelline cellsSitu hybridizationGenesMRNASchistosoma mansoniEgg productionExpressionWormsSequenceCDNA
1987
Functional significance of periovular granuloma in schistosomiasis.
Reis M, Andrade Z. Functional significance of periovular granuloma in schistosomiasis. Brazilian Journal Of Medical And Biological Research 1987, 20: 55-62. PMID: 3120841.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGranulomaIntestinesLiverLungMiceParasite Egg CountSchistosoma mansoniSchistosomiasis mansoniSchistosomicidesConceptsPeriovular granulomasSchistosoma mansoni cercariaeCurative chemotherapyLate infectionMansoni cercariaeGranulomasPresent findingsSchistosomiasisDifferent organsHost tissuesFunctional significanceTissuePrevious studiesChemotherapyDifferent morphological typesViable eggsInfectionMiceSecretionWeeks
1986
Stage and species specificity of antigens encoded by two geographic strains of Schistosoma mansoni mRNA.
Blanton R, Horowitz S, Reis M, Rottman F, Andrade Z, Mahmoud A. Stage and species specificity of antigens encoded by two geographic strains of Schistosoma mansoni mRNA. Journal Of Parasitology 1986, 72: 445-53. PMID: 3091803, DOI: 10.2307/3281685.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, HelminthBrazilCross ReactionsHumansMiceMice, Inbred C57BLMolecular WeightProtein BiosynthesisPuerto RicoRNA, MessengerSchistosoma haematobiumSchistosoma japonicumSchistosoma mansoniSchistosomiasis haematobiaSchistosomiasis japonicaSchistosomiasis mansoniSpecies SpecificityConceptsS. mansoniImmune human seraAntigen of MrGroup of antigensAdult worm mRNAAntigenic poolSchistosome infectionIntensity of infectionSchistosoma haematobiumIndividual seraAntigenAntigenic specificityAntigenic differencesSerumSchistosoma japonicumCross-reactive proteinEgg countsBrazilian parasitesInfectionMansoniMolecular weight proteinsHuman serumDifferent geographic strainsSpecies specificityHigh molecular weight proteins