2010
Iinsulin Levels and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) May Explain a Possible Important Role of the Pancreas In Sickle Cell Disease Patients Outcome
Seixas M, Lopes V, Cezar R, Carvalho G, Rocha L, Lyra I, Reis M, Goncalves M. Iinsulin Levels and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) May Explain a Possible Important Role of the Pancreas In Sickle Cell Disease Patients Outcome. Blood 2010, 116: 4811. DOI: 10.1182/blood.v116.21.4811.4811.Peer-Reviewed Original ResearchSickle cell diseaseC-reactive proteinInsulin levelsBlood cell countSCD patientsAspartate aminotransferaseHOMA-IRWBC countLactate dehydrogenaseHemoglobin concentrationCell countSeverity of SCDChronic sub-clinical inflammationWhite blood cell countSub-clinical inflammationHigher insulin levelsRed blood cell countCross-sectional studyLower insulin levelsHigher ferritin concentrationsHigher haptoglobin concentrationsImportant biomarkerInflammatory markersPain episodesChronic inflammation
2009
Lipoprotein Cholesterol and Triglyceride in Children with Steady-State Sickle Cell Disease.
Seixas M, Rocha L, Carvalho M, Menezes J, Lyra I, Nascimento V, Couto R, Atta A, Reis M, Goncalves M. Lipoprotein Cholesterol and Triglyceride in Children with Steady-State Sickle Cell Disease. Blood 2009, 114: 1547. DOI: 10.1182/blood.v114.22.1547.1547.Peer-Reviewed Original ResearchHigh-density lipoprotein cholesterolLipoprotein cholesterolSickle cell disease pathogenesisPatients' medical recordsSickle cell diseasePro-fibrinolytic activityTotal cholesterolSignificant positive associationProspective studyMedical recordsSteady state childrenCell diseaseClinical dataHealthy subjectsDisease pathogenesisHematological analysisCholesterolCell counterPositive associationNegative associationElectronic cell counterAssociationPatientsPathogenesisMonocytes