2011
Lymphocyte Surface Molecule Expression on Basal State and After Challenge: Association of Clinical Profile, Inflammation, Hematological and Biochemical Markers in Sickle Cell Anemia Patients
Cerqueira B, Vilas-Boas W, Zanette A, Clarencio J, Salvino M, Cezar R, Andrade D, Reis M, Goncalves M. Lymphocyte Surface Molecule Expression on Basal State and After Challenge: Association of Clinical Profile, Inflammation, Hematological and Biochemical Markers in Sickle Cell Anemia Patients. Blood 2011, 118: 2146. DOI: 10.1182/blood.v118.21.2146.2146.Peer-Reviewed Original ResearchSickle cell anemia patientsSoluble adhesion moleculesSickle cell anemiaSurface molecule expressionSCA patientsControl groupAnemia patientsAdhesion moleculesLymphocyte expressionLPS challengeMedical historyCD18 expressionMolecule expressionSoluble vascular adhesion moleculeBasal statePro-inflammatory interactionsEffector immune responsesVaso-occlusive episodesExpression of CD62LMarkers of inflammationChronic inflammatory stateTNF-alpha valuesVascular adhesion moleculesComplete medical historyExpression of CD11bTNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia
Cajado C, Cerqueira B, Couto F, Moura-Neto J, Vilas-Boas W, Dorea M, Lyra I, Barbosa C, Reis M, Goncalves M. TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia. Cytokine 2011, 56: 312-317. PMID: 21802960, DOI: 10.1016/j.cyto.2011.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesAnemia, Sickle CellBiomarkersCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayHaplotypesHumansInterleukin-8Medical History TakingPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthTumor Necrosis Factor-alphaConceptsSickle cell anemiaTNF-alpha -308GT gene polymorphismGene polymorphismsIL-8Serum levelsMedical historyTNF-alphaCell anemiaHigher TNF-alpha levelsIL-8 gene polymorphismsA alleleClassical biomarkersSteady-state sickle cell anemiaTNF-alpha levelsHeterogeneous clinical outcomesLogistic regression analysisYears of ageCytokine levelsClinical outcomesImmunological biomarkersHealthy controlsPatient outcomesInterleukin-8SCA patients
2010
CD32, CD18, CD11b and CD62L Expression on Monocyte without and After Lipopolysaccharide (LPS) Challenge: Association with Inflammatory and Hemolysis Markers In Sickle Cell Anemia.
Cerqueira B, Vilas-Boas W, Neto J, Clarencio J, Andrade D, Cezar R, Zanette A, Reis M, Goncalves M. CD32, CD18, CD11b and CD62L Expression on Monocyte without and After Lipopolysaccharide (LPS) Challenge: Association with Inflammatory and Hemolysis Markers In Sickle Cell Anemia. Blood 2010, 116: 1655. DOI: 10.1182/blood.v116.21.1655.1655.Peer-Reviewed Original ResearchSickle cell anemiaVaso-occlusive episodesExpression of CD11bMonocyte expressionSCA patientsControl groupCell anemiaRed blood cellsMedical historyLipid metabolismHemoglobin SMarkers of hemolysisSurface molecule expressionComplete medical historySurface moleculesMonocyte surface moleculesSickle red blood cellsProinflammatory interactionsCD62L expressionOutpatient clinicCD32 expressionVascular occlusionHemolysis markersSplenic sequestrationTNF-alpha
2009
Adhesion Molecules Interaction with Markers of Lipid Metabolism, Hemolysis, Endothelial Dysfunction and Medical Histories Among Steady-State Sickle Cell Anemia Patients.
Cerqueira B, Boas W, Clarêncio J, Andrade D, Zanette A, Reis M, Neto J, Cesar R, Goncalves M. Adhesion Molecules Interaction with Markers of Lipid Metabolism, Hemolysis, Endothelial Dysfunction and Medical Histories Among Steady-State Sickle Cell Anemia Patients. Blood 2009, 114: 2553. DOI: 10.1182/blood.v114.22.2553.2553.Peer-Reviewed Original ResearchSickle cell anemia patientsSickle cell anemiaSoluble adhesion moleculesHigher serum levelsMedical historyAnemia patientsAdhesion moleculesEndothelial dysfunctionSerum levelsICAM-1Aspartate transferaseSteady-state sickle cell anemia patientsDensity lipoproteinControl groupVCAM-1 adhesion moleculesLipid metabolismChronic clinical complicationsVaso-occlusive painSurface adhesion molecule expressionNeutrophil adhesion moleculesSoluble ICAM-1Complete medical historyAdhesion molecule expressionHigh-density lipoproteinLow-density lipoprotein
2008
Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil
Adorno E, Zanette Â, Lyra I, Seixas M, Reis M, Gonçalves M. Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil. Genetics And Molecular Biology 2008, 31: 621-625. DOI: 10.1590/s1415-47572008000400003.Peer-Reviewed Original ResearchSevere sickle cell anemiaSickle cell anemiaCell anemiaBeta S-globin gene haplotypesMean hemoglobin concentrationLow mean corpuscular volumeMean corpuscular volumeErythrocyte transfusionCerebrovascular accidentHigher mean hemoglobin concentrationHigh HbF levelsClinical dataCAR haplotypeHemoglobin concentrationCorpuscular volumeCorpuscular hemoglobinOutpatientsHbF levelsFetal hemoglobinAnemiaPCR-RFLPCarrier valuesHemoglobinGene haplotypesMolecular characteristics