2024
IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease
Serrano I, Ribeiro G, Santos R, Cruz J, Lanza F, dos Santos E, de Almeida M, de Souza Soares J, Luquetti A, Celedon P, Zanchin N, Santos F, dos Reis M. IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease. American Journal Of Tropical Medicine And Hygiene 2024, 110: 669-676. PMID: 38412539, PMCID: PMC10993828, DOI: 10.4269/ajtmh.23-0652.Peer-Reviewed Original ResearchClinical presentationChronic CDClinical formsSpectrum of clinical presentationsIg profilesSevere cardiac involvementChagas diseaseChronic Chagas diseaseSerum samplesDevelopment of tissue damageHost immune responseCross-sectional studyCardiac involvementIgG3 levelsImmunopathogenic mechanismsDisease progressionProgression of CDRecombinant chimeric proteinImmune responseIgG isotypeIgG3 isotypesTotal IgGMC groupSC groupDisease pathogenesis
2020
Transmission of Chikungunya Virus in a Brazilian Urban Slum - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC
Anjos RO, Mugabe VA, Moreira PSS, Carvalho CX, Portilho MM, Khouri R, Sacramento GA, Nery NRR, Reis MG, Kitron UD, Ko AI, Costa F, Ribeiro GS. Transmission of Chikungunya Virus in a Brazilian Urban Slum - Volume 26, Number 7—July 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 1364-1373. PMID: 32568045, PMCID: PMC7323528, DOI: 10.3201/eid2607.190846.Peer-Reviewed Original ResearchConceptsEpisodes of feverChikungunya outbreakInfectious Diseases journal - CDCSymptomatic infection ratePresumptive clinical diagnosisSufficient herd immunityCommunity-based studyFurther longitudinal studiesCHIKV seroprevalenceSeropositive personsVirus seroprevalenceClinical dataHerd immunityChikungunya virusInfection rateClinical diagnosisSerum samplesDisease pointUnpaved streetsArthralgiaLongitudinal studyFeverSeroprevalenceEpisodesOutbreak
2008
Distribution of Hepatitis C virus (HCV) genotypes in seropositive patients in the state of Alagoas, Brazil
Gonzaga R, Rodart I, Reis M, Neto C, Silva D. Distribution of Hepatitis C virus (HCV) genotypes in seropositive patients in the state of Alagoas, Brazil. Brazilian Journal Of Microbiology 2008, 39: 644-647. PMID: 24031281, PMCID: PMC3768450, DOI: 10.1590/s1517-83822008000400008.Peer-Reviewed Original ResearchAnti-HCV seropositive patientsHepatitis C virus genotypesC virus genotypesSeropositive patientsGenotype 1Genotype 2Nested-reverse transcription-polymerase chain reactionVirus genotypesDetectable HCV RNATranscription-polymerase chain reactionRestriction fragment length polymorphismGenotype-specific primersHCV RNAGenotype 3Subtype 1bSubtype 1aPatientsSerum samplesChain reactionSignificant differencesFragment length polymorphismState of AlagoasLength polymorphismCoinfectionPrevalence
2000
Hepatitis C virus genotypes in a northeastern area of Brazil.
Silva L, Paraná R, Souza S, Berby F, Kay A, Trepó C, Santana N, Cotrim H, Lyra L, Reis M. Hepatitis C virus genotypes in a northeastern area of Brazil. American Journal Of Tropical Medicine And Hygiene 2000, 62: 257-60. PMID: 10813481, DOI: 10.4269/ajtmh.2000.62.257.Peer-Reviewed Original ResearchConceptsHepatitis C virusReverse transcription-polymerase chain reactionC virusGenotyping of HCVTranscription-polymerase chain reactionSeropositive serum samplesGenotype-specific primersWarrants further investigationGenotype 3Subtype 1aAlanine aminotransferaseGenotype distributionAspartate aminotransferaseSerum samplesMixed genotypesChain reactionViral RNACity of SalvadorFurther investigationAminotransferaseVirusBrazilian samplePatientsHigh frequencyGenotypes