2022
Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil
Cruz J, Nery N, Sacramento G, Victoriano R, Montenegro A, Santana J, Costa F, Ko A, Reis M, Wunder E. Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil. Frontiers In Medicine 2022, 9: 862378. PMID: 35492362, PMCID: PMC9048256, DOI: 10.3389/fmed.2022.862378.Peer-Reviewed Original ResearchMicroscopic agglutination testAntibody kineticsEndemic areasReinfection eventsSubcohort of individualsBurden of leptospirosisLife-threatening diseaseProspective cohortClinical manifestationsAsymptomatic infectionHumoral responseRisk factorsImmune responseLeptospirosis infectionAgglutination testPaucity of informationSerological surveyLeptospirosisSample collection timeInfectionLeptospira interrogansSubcohortFurther studiesHigh rateDisease
2021
Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs
Santos A, dos Santos Ribeiro P, da França G, Souza F, Ramos E, Figueira C, Reis M, Costa F, Ristow P. Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. PLOS Neglected Tropical Diseases 2021, 15: e0009736. PMID: 34495971, PMCID: PMC8451993, DOI: 10.1371/journal.pntd.0009736.Peer-Reviewed Original ResearchConceptsRenal tubulesPathogenic LeptospiraPathogenesis of leptospirosisMain reservoir hostsNatural animal reservoirsBacterial carriageChronic colonizationLeptospiral colonizationRenal carriageAnimal reservoirsLeptospira interrogansLeptospirosisUrban slumsCausative agentLeptospiraTubulesPossible roleReservoir hostsCarriageNatural reservoirBiofilm formationOcclusion patternsBacterial survivalHost reservoirsR. norvegicus
2020
Early Release - Anicteric Leptospirosis-Associated Meningitis in a Tropical Urban Environment, Brazil - Volume 26, Number 9—September 2020 - Emerging Infectious Diseases journal - CDC
Nabity SA, Araújo GC, Hagan JE, Damião AO, Reis MG, Ko AI, Ribeiro GS. Early Release - Anicteric Leptospirosis-Associated Meningitis in a Tropical Urban Environment, Brazil - Volume 26, Number 9—September 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 2190-2192. PMID: 32818405, PMCID: PMC7454101, DOI: 10.3201/eid2609.191001.Peer-Reviewed Original Research
2010
Cytokines in experimental leptospirosis: Association with severe disease and postimmunization immune response
Chagas-Junior A, Athanazio D, Macedo J, Menezes M, Reis M, McBride F, McBride A. Cytokines in experimental leptospirosis: Association with severe disease and postimmunization immune response. International Journal Of Infectious Diseases 2010, 14: e189-e190. DOI: 10.1016/j.ijid.2010.02.1909.Peer-Reviewed Original Research
2007
Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection
de Faria M, Athanazio DA, Ramos E, Silva EF, Reis MG, Ko AI. Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection. Journal Of Comparative Pathology 2007, 137: 231-238. PMID: 17996544, DOI: 10.1016/j.jcpa.2007.08.001.Peer-Reviewed Original ResearchConceptsInterstitial nephritisPathology of leptospirosisKidneys of ratsMorphological alterationsPathogenesis of leptospirosisFiocruz L1-130Leptospiral diseaseWistar ratsLeptospira infectionPathological changesUrban outbreaksRecreational exposureHuman infectionsL1-130RatsWidespread anthropozoonosisKidneyLeptospira interrogansLeptospirosisNephritisInfectionDiseaseEmergent diseaseMammalian reservoirsHost resistance
2002
Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic.
Sarkar U, Nascimento S, Barbosa R, Martins R, Nuevo H, Kalofonos I, Kalafanos I, Grunstein I, Flannery B, Dias J, Riley L, Reis M, Ko A. Population-based case-control investigation of risk factors for leptospirosis during an urban epidemic. American Journal Of Tropical Medicine And Hygiene 2002, 66: 605-10. PMID: 12201599, DOI: 10.4269/ajtmh.2002.66.605.Peer-Reviewed Original ResearchConceptsRisk factorsUrban epidemicPopulation-based case-control studyPopulation-based case-control investigationIndependent risk factorLaboratory-confirmed casesHealthy neighbourhood controlsCase-control investigationCase-control studyCases of leptospirosisSevere leptospirosisWeil's syndromeWorkplace exposuresNeighborhood controlsHigh endemicityLeptospirosisFocused interventionsMore ratsSyndromeRatsEpidemicEnvironmental sourcesComplicationsFactorsMortality
2001
Referral pattern of leptospirosis cases during a large urban epidemic of dengue.
Flannery B, Pereira MM, Velloso L de F, Carvalho C de C, De Codes LG, Orrico G de S, Dourado CM, Riley LW, Reis MG, Ko AI. Referral pattern of leptospirosis cases during a large urban epidemic of dengue. American Journal Of Tropical Medicine And Hygiene 2001, 65: 657-63. PMID: 11716133, DOI: 10.4269/ajtmh.2001.65.657.Peer-Reviewed Original ResearchConceptsInfectious diseases reference hospitalFirst medical evaluationLarge urban epidemicDays of illnessInfectious Diseases HospitalIntensive care unitOnset of illnessCases of leptospirosisDiagnosis of dengueDiseases HospitalCare unitInitial diagnosisReference hospitalReferral patternsAmbulatory clinicsLeptospirosis epidemicMedical evaluationConcurrent epidemicsDengue diagnosisDiagnostic confusionUrban epidemicEarly symptomsHigh mortalityLeptospirosis casesLeptospirosisEvaluation of Recombinant Leptospira Antigen-Based Enzyme-Linked Immunosorbent Assays for the Serodiagnosis of Leptospirosis
Flannery B, Costa D, Carvalho F, Guerreiro H, Matsunaga J, Da Silva E, Ferreira A, Riley L, Reis M, Haake D, Ko A. Evaluation of Recombinant Leptospira Antigen-Based Enzyme-Linked Immunosorbent Assays for the Serodiagnosis of Leptospirosis. Journal Of Clinical Microbiology 2001, 39: 3303-3310. PMID: 11526167, PMCID: PMC88335, DOI: 10.1128/jcm.39.9.3303-3310.2001.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayIgG enzyme-linked immunosorbent assaySerodiagnosis of leptospirosisHealthy individualsImmunosorbent assayTest-positive individualsCases of leptospirosisHigh-incidence regionsLyme disease patientsMicroscopic agglutination testConvalescent phaseHepatitis patientsAcute phaseDengue patientsDisease patientsPatient seraHealthy residentsLeptospira antigensCutoff valueDiagnostic utilityPatientsAgglutination testUseful antigenLeptospirosisAntigenLeptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans
Guerreiro H, Croda J, Flannery B, Mazel M, Matsunaga J, Reis M, Levett P, Ko A, Haake D. Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans. Infection And Immunity 2001, 69: 4958-4968. PMID: 11447174, PMCID: PMC98588, DOI: 10.1128/iai.69.8.4958-4968.2001.Peer-Reviewed Original ResearchConceptsHumoral immune responseImmune responseNatural infectionLeptospiral proteinsInfection-associated antigenConvalescent-phase seraPositive reactionConvalescent phaseHumoral responseHealthy individualsHuman leptospirosisControl individualsVaccine designImmunodominant antigensQuantitative immunoblot analysisTwo-dimensional immunoblotsProtein antigensPathogenic leptospiral strainsGenus LeptospiraInfectionAntigenLeptospirosisSerumImmunodominant proteinsPatients