2022
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Eyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil. ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.Peer-Reviewed Original ResearchConceptsInfection riskSignificant global public health burdenCommunity-based cohort studyGlobal public health burdenPublic health burdenAgents of leptospirosisExposure of interestYears of agePublic health interventionsHigh-risk communitiesJoint spatial modellingZoonotic spilloverCohort studyHuman infection riskMale genderSerological evidenceHealth burdenLeptospira infectionLeptospiral infectionInfection rateHealth interventionsEco-epidemiological studiesHealth surveillanceFundação de Amparo à PesquisaOswaldo Cruz Foundation
2020
Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC
Hacker KP, Sacramento GA, Cruz JS, de Oliveira D, Nery N, Lindow JC, Carvalho M, Hagan J, Diggle PJ, Begon M, Reis MG, Wunder EA, Ko AI, Costa F. Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 311-314. PMID: 31961288, PMCID: PMC6986844, DOI: 10.3201/eid2602.190102.Peer-Reviewed Original Research
2007
Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection
de Faria M, Athanazio DA, Ramos E, Silva EF, Reis MG, Ko AI. Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection. Journal Of Comparative Pathology 2007, 137: 231-238. PMID: 17996544, DOI: 10.1016/j.jcpa.2007.08.001.Peer-Reviewed Original ResearchConceptsInterstitial nephritisPathology of leptospirosisKidneys of ratsMorphological alterationsPathogenesis of leptospirosisFiocruz L1-130Leptospiral diseaseWistar ratsLeptospira infectionPathological changesUrban outbreaksRecreational exposureHuman infectionsL1-130RatsWidespread anthropozoonosisKidneyLeptospira interrogansLeptospirosisNephritisInfectionDiseaseEmergent diseaseMammalian reservoirsHost resistance