2021
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
Jacob-Nascimento L, Carvalho C, Silva M, Kikuti M, Anjos R, Fradico J, Campi-Azevedo A, Tauro L, Campos G, dos Santos Moreira P, Portilho M, Martins-Filho O, Ribeiro G, Reis M. Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection. Frontiers In Immunology 2021, 12: 744183. PMID: 34659240, PMCID: PMC8517435, DOI: 10.3389/fimmu.2021.744183.Peer-Reviewed Original ResearchConceptsChikungunya virus infectionCHIKV infectionHealthy controlsIL-12IL-1βVirus infectionFlow cytometric bead arrayAcute phase immune responseAcute CHIKV infectionAnti-CHIKV IgMAcute-phase samplesCytometric bead arrayAcute febrile diseaseAcute-phase levelsCHIKV patientsSerum chemokinesCXCL10 levelsPain persistenceIL-10Cytokine kineticsMultivariable analysisCXCL8 levelsIL-6Female sexIL-2
2008
Schistosoma mansoni Triose Phosphate Isomerase Peptide MAP4 is Able to Trigger Naïve Donor Immune Response Towards a Type‐1 Cytokine Profile
Reis E, Carmo T, Athanazio R, Reis M, Harn D. Schistosoma mansoni Triose Phosphate Isomerase Peptide MAP4 is Able to Trigger Naïve Donor Immune Response Towards a Type‐1 Cytokine Profile. Scandinavian Journal Of Immunology 2008, 68: 169-176. PMID: 18565118, DOI: 10.1111/j.1365-3083.2008.02131.x.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsSchistosoma mansoni soluble egg antigenDendritic cellsCytokine productionAutologous peripheral blood mononuclear cellsType 1 cytokine profileMonocyte-derived dendritic cellsDonor dendritic cellsDonor immune responsesTh1-type responseT cell subsetsBlood mononuclear cellsIFN-gamma productionT cell epitopesMultiple antigen peptideMajor cell populationRecall stimulationCytokine profileIL-10Egg antigenMononuclear cellsT cellsImmune responseIFN-gammaMouse model
2007
Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens
Reis E, Azevedo T, McBride A, Harn D, Reis M. Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens. Scandinavian Journal Of Immunology 2007, 66: 662-670. PMID: 18021364, DOI: 10.1111/j.1365-3083.2007.02024.x.Peer-Reviewed Original ResearchConceptsSchistosoma mansoni soluble egg antigenNaïve human peripheral blood mononuclear cellsSoluble egg antigenIL-10Egg antigenIL-5T cellsT helper cell responsesHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsDonor dendritic cellsTh2-type responseTh2-like responseBlood mononuclear cellsPronounced CD4Dendritic cellsIL-12p40Immune suppressionIL-6Mononuclear cellsCytokine secretionDonor responsesIFN-gammaCD4Day 7