The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts
Clark M, Jembere N, Kupets R. The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts. Preventive Medicine 2021, 150: 106641. PMID: 34048822, DOI: 10.1016/j.ypmed.2021.106641.Peer-Reviewed Original ResearchConceptsSchool-based human papillomavirus (HPV) vaccination programLower genital tract dysplasiaPre-invasive diseaseTreatment of HPVVaccination programGenital wartsCervical dysplasiaCytologic abnormalitiesRelative riskHuman papilloma virus vaccination programmesLow-grade cytologic abnormalitiesHuman papillomavirus vaccination programmeLower genital tractHigh-grade abnormalitiesRelative risk ratiosCervical conizationUnvaccinated womenVaccinated womenHPV vaccineColposcopy servicesUnvaccinated groupVaccinated groupRisk ratioCytology resultsAdministrative databasesEndometrial Carcinoma as the Presenting Malignancy in a Teenager With a Pathogenic TP53 Germline Mutation: A Case Report and Literature Review
Irshaid L, Clark M, Fadare O, Finberg KE, Parkash V. Endometrial Carcinoma as the Presenting Malignancy in a Teenager With a Pathogenic TP53 Germline Mutation: A Case Report and Literature Review. International Journal Of Gynecological Pathology 2021, 41: 258-267. PMID: 33990091, DOI: 10.1097/pgp.0000000000000792.Peer-Reviewed Original ResearchConceptsGermline TP53 mutationsEndometrial carcinomaTP53 mutationsGermline mutationsMissense substitution p.Predominant tumor typePremenopausal breast carcinomaAdrenal cortical tumorsTP53 geneTP53 germline mutationsSoft tissue sarcomasEndometrioid endometrial carcinomaEarly-onset malignanciesLi-Fraumeni syndromeAutosomal dominant disorderCortical tumorsPresenting tumourGynecologic malignanciesTissue sarcomasUterine carcinomaCase reportSpinal cordBreast carcinomaGrade 3Characteristic syndrome