The modeled CA-125 elimination rate constant k (KELIM) score as a predictor of treatment response in patients with advanced high grade serous ovarian cancer (190)
Piedimonte S, Kim S, Clark M, Lheureux S, May T, Bernardini M, Atenafu E. The modeled CA-125 elimination rate constant k (KELIM) score as a predictor of treatment response in patients with advanced high grade serous ovarian cancer (190). Gynecologic Oncology 2022, 166: s109. DOI: 10.1016/s0090-8258(22)01417-2.Peer-Reviewed Original ResearchHigh-grade serous ovarian cancerAdvanced high-grade serous ovarian cancerPlatinum-free intervalSerous ovarian cancerNeoadjuvant chemotherapyOverall survivalCA 125BRCA statusOvarian cancerHigh CA 125 levelsMedian platinum-free intervalKaplan-Meier survival analysisGrade serous ovarian cancerBaseline CA-125Lower median PFSCA-125 levelsPlatinum-resistant diseasePlatinum-sensitive diseaseRetrospective cohort studyTertiary cancer centerDays of chemotherapySubset of patientsCA 125 valuesBRCA mutation statusSignificant differences