2022
Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesia, ObstetricalAnesthetics, LocalFemaleHumansInfant, NewbornPregnancyProcaineProspective StudiesConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2018
The use of acute normovolemic hemodilution in paediatric cardiac surgery
Crescini WM, Muralidaran A, Shen I, LeBlanc A, You J, Giacomuzzi C, Treggiari MM. The use of acute normovolemic hemodilution in paediatric cardiac surgery. Acta Anaesthesiologica Scandinavica 2018, 62: 756-764. PMID: 29504128, DOI: 10.1111/aas.13095.Peer-Reviewed Original ResearchConceptsAcute normovolemic hemodilutionPediatric cardiac surgery patientsCardiac surgery patientsBlood productsHospital stayBaseline characteristicsSurgery patientsBlood lossNormovolemic hemodilutionSingle-center retrospective cohort studyUse of ANHHigh blood loss surgeryLower postoperative blood lossCongenital Heart Surgery scoreAllogenic blood productsAllogeneic blood productsDuration of ICUPostoperative blood lossRetrospective cohort studyLower blood lossPediatric cardiac surgeryMonths of ageAnaesthesiologists classificationANH groupPerioperative transfusion