2021
Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatients
2020
Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults.
Tiwary N, Treggiari MM, Yanez ND, Kirsch JR, Tekkali P, Taylor CC, Schenning KJ. Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults. Anesthesia & Analgesia 2020, 132: 1112-1119. PMID: 33002933, DOI: 10.1213/ane.0000000000005197.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnesthesia Recovery PeriodAnesthesia, GeneralCognitionCognitive DysfunctionElective Surgical ProceduresEmergence DeliriumFemaleHumansMaleMental Status and Dementia TestsPredictive Value of TestsPreoperative CareReproducibility of ResultsRisk AssessmentRisk FactorsTreatment OutcomeConceptsPostanesthesia care unitMini-Cog scorePACU deliriumDay of surgeryTimes higher oddsNormal cognitive functionCohort studyCognitive impairmentMini-CogPostoperative deliriumCognitive functionPreoperative clinicHigher oddsPatients meeting eligibility criteriaPostanesthesia Care Unit DeliriumShort Confusion Assessment MethodConfusion Assessment MethodOlder surgical patientsProspective cohort studyAnesthesiologists physical statusMultivariable logistic regressionMeeting eligibility criteriaSubjective memory impairmentOdds ratio analysisOlder patientsRandomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery
Togioka BM, Yanez D, Aziz MF, Higgins JR, Tekkali P, Treggiari MM. Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery. British Journal Of Anaesthesia 2020, 124: 553-561. PMID: 32139135, DOI: 10.1016/j.bja.2020.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCholinesterase InhibitorsDelayed Emergence from AnesthesiaDouble-Blind MethodFemaleHumansIntraoperative PeriodLung DiseasesMaleNeostigmineNeuromuscular BlockadeNeuromuscular JunctionNeuromuscular Nondepolarizing AgentsPatient ReadmissionPostoperative ComplicationsRocuroniumSugammadexConceptsPostoperative pulmonary complicationsResidual neuromuscular blockPulmonary complicationsDay hospital readmissionNeuromuscular blockPrimary endpointHospital readmissionDay hospital readmission rateOlder adultsHospital readmission ratesPhase 1 recoveryRocuronium reversalNeostigmine groupSecondary endpointsSugammadex groupReadmission ratesResidual paralysisSurgical closureSugammadexComplicationsNeostigmineLarger studySurgeryIncidenceEndpoint
2018
Right Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery
Yockelson SR, Heitner SB, Click S, Geleto G, Treggiari MM, Hutchens MP. Right Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2018, 33: 725-731. PMID: 30316640, PMCID: PMC6379134, DOI: 10.1053/j.jvca.2018.09.012.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRV systolic pressureSpeckle tracking echocardiographyCardiac surgeryAKI groupTransthoracic echocardiogramKidney injurySystolic pressureMyocardial performanceElevated RV systolic pressureRight ventricular myocardial performanceCardiovascular intensive care unitRetrospective observational cohort studyRV myocardial performancePreoperative serum creatinineCardiac surgery patientsCentral venous pressureObservational cohort studyVentricular systolic performanceSerum creatinine valuesVentricular myocardial performanceBody mass indexIntensive care unitIntravascular volume statusSpeckle-tracking analysis
2017
Process Improvement Initiative for the Perioperative Management of Patients With a Cardiovascular Implantable Electronic Device
Ellis MKM, Treggiari MM, Robertson JM, Rozner MA, Graven PF, Aziz MF, Merkel MJ, Kahl EA, Cohen NA, Stecker EC, Schulman PM. Process Improvement Initiative for the Perioperative Management of Patients With a Cardiovascular Implantable Electronic Device. Anesthesia & Analgesia 2017, 125: 58-65. PMID: 28319519, DOI: 10.1213/ane.0000000000001953.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedAged, 80 and overCardiac Surgical ProceduresCardiovascular SystemCohort StudiesDefibrillators, ImplantableFemaleHealth Care CostsHumansMaleMiddle AgedOperating RoomsOutcome and Process Assessment, Health CarePacemaker, ArtificialPatient SafetyPerioperative CarePerioperative PeriodRisk AssessmentTime FactorsConceptsCardiovascular implantable electronic devicesSafe perioperative carePreintervention periodPostintervention periodImplantable electronic devicesPerioperative carePerioperative surgical home modelPrimary end pointCohort of patientsSame eligibility criteriaLarge academic medical centerPatient Safety DatabaseImprovement initiativesAcademic medical centerAdequate patient safetyNew care modelsImproved operating room efficiencyBaseline characteristicsAdverse eventsPerioperative managementPotential confoundersConcurrent cohortDay surgerySurgical proceduresCare model
2014
Preoperative Consultations for Medicare Patients Undergoing Cataract Surgery
Thilen SR, Treggiari MM, Lange JM, Lowy E, Weaver EM, Wijeysundera DN. Preoperative Consultations for Medicare Patients Undergoing Cataract Surgery. JAMA Internal Medicine 2014, 174: 380-388. PMID: 24366269, PMCID: PMC4167873, DOI: 10.1001/jamainternmed.2013.13426.Peer-Reviewed Original ResearchConceptsPreoperative consultationCataract surgeryHierarchical logistic regression modelingPatients 66 yearsElective surgical proceduresLogistic regression modelingIndex surgeryCohort studyEntire cohortElective proceduresSurgical proceduresMAIN OUTCOMEMedicare beneficiariesSurgeryMedicare Part BAnesthesia providersNational random sampleUrban residenceTemporal trendsRegression modelingConsultationCohortFacility typeSuch consultationsClear guidelines
2013
Patterns of Preoperative Consultation and Surgical Specialty in an Integrated Healthcare System
Thilen SR, Bryson CL, Reid RJ, Wijeysundera DN, Weaver EM, Treggiari MM. Patterns of Preoperative Consultation and Surgical Specialty in an Integrated Healthcare System. Anesthesiology 2013, 118: 1028-1037. PMID: 23503373, PMCID: PMC4162741, DOI: 10.1097/aln.0b013e31828ea68a.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overCohort StudiesComorbidityDelivery of Health Care, IntegratedFemaleHealth Status IndicatorsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisPractice Patterns, Physicians'Preoperative PeriodPrescription DrugsReferral and ConsultationRiskSpecialties, SurgicalSurgical Procedures, OperativeYoung AdultConceptsIntegrated healthcare systemPreoperative consultationSurgical specialtiesHealthcare systemDeyo comorbidity indexPreoperative medical consultationsCardiac Risk IndexCardiac risk scoreLow-risk surgeryLow cardiac riskGroup Health CooperativeSubstantial practice variationMultivariable logistic regressionComorbidity indexMedication classesCohort studyCardiac riskElective surgeryPotential confoundersPrescription medicationsHealth CooperativeOdds ratioPractice variationGeneral internistsFamily physicians
2011
Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury
Chaiwat O, Vavilala MS, Philip S, Malakouti A, Neff MJ, Deem S, Treggiari MM, Wang J, Lang JD. Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury. Journal Of Critical Care 2011, 26: 144-151. PMID: 20869200, DOI: 10.1016/j.jcrc.2010.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAdolescentAdultAgedAged, 80 and overAPACHECritical IllnessFemaleGuideline AdherenceHospital MortalityHumansInjury Severity ScoreIntraoperative PeriodLength of StayMaleMiddle AgedPositive-Pressure RespirationPractice Guidelines as TopicRetrospective StudiesRisk FactorsTidal VolumeYoung AdultConceptsAcute respiratory distress syndromeAcute lung injuryALI/acute respiratory distress syndromeLTV ventilationLung injuryClinical outcomesLow tidal volume ventilation strategyALI/ARDS diagnosisLow tidal volume ventilationVolume ventilation strategyRespiratory distress syndromeTidal volume ventilationARDS diagnosisHospital mortalityIntraoperative adherenceHospital lengthSecondary outcomesSurgical patientsDistress syndromeIll patientsVolume ventilationImproved oxygenationPatient outcomesRetrospective analysisMAIN OUTCOME
2008
The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury
Cooke CR, Watkins TR, Kahn JM, Treggiari MM, Caldwell E, Hudson LD, Rubenfeld GD. The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Critical Care 2008, 12: r134. PMID: 18980682, PMCID: PMC2646342, DOI: 10.1186/cc7105.Peer-Reviewed Original ResearchConceptsClosed intensive care unitAcute lung injuryIntensive care unitLung injuryCare unitTidal volumeProspective population-based cohortLow VTOpen intensive care unitIntensivist physician staffingPopulation-based cohortProcess of careHospital mortalityVentilatory practicesImproved mortalityIntensive carePhysician staffingPatient outcomesMean VTPatientsDay threeSecondary analysisPotential patientsHigh VTKing County
2004
Occupational asbestos exposure and the incidence of non-hodgkin lymphoma of the gastrointestinal tract: an ecologic study
Treggiari MM, Weiss NS. Occupational asbestos exposure and the incidence of non-hodgkin lymphoma of the gastrointestinal tract: an ecologic study. Annals Of Epidemiology 2004, 14: 168-171. PMID: 15036219, DOI: 10.1016/s1047-2797(03)00241-2.Peer-Reviewed Original ResearchConceptsOccupational asbestos exposureNon-Hodgkin lymphomaRates of mesotheliomaAsbestos exposureGastrointestinal tractNational Cancer Institute's SurveillanceEcologic studyPrevious case-control studyIncidence of malignancyEnd Results ProgramCase-control studyMen age 50Results ProgramOccupational exposureSubsequent incidenceAge 50IncidenceMesotheliomaStrong associationLymphomaTractExposureSurveillanceUS regionsSan FranciscoTranspulmonary lactate gradient after hypothermic cardiopulmonary bypass
Bendjelid K, Treggiari MM, Romand JA. Transpulmonary lactate gradient after hypothermic cardiopulmonary bypass. Intensive Care Medicine 2004, 30: 817-821. PMID: 14985958, DOI: 10.1007/s00134-004-2179-7.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypass durationAcute lung injuryPulmonary lactate releaseCardiopulmonary bypassBypass durationLactate releaseAortic cross-clamping timeEffects of CPBPost-cardiac surgery patientsCross-clamping timePulmonary artery catheterVenous blood samplesHypothermic cardiopulmonary bypassConclusionThe present studyPulmonary releaseCardiac indexArtery catheterLung injurySurgery patientsSurgical ICUMechanical ventilationCardiac outputUniversity HospitalBlood samplesPatients
2002
Postmenopausal hormone use and skeletal fracture: does the size of the benefit decrease with increasing age?
Weiss NS, Treggiari MM. Postmenopausal hormone use and skeletal fracture: does the size of the benefit decrease with increasing age? Obstetrics And Gynecology 2002, 100: 364-8. PMID: 12151165, DOI: 10.1016/s0029-7844(02)02046-x.Peer-Reviewed Original ResearchConceptsLong-term hormone useOlder postmenopausal womenPostmenopausal womenHormone useFracture riskYounger postmenopausal womenPostmenopausal hormone useSurrogate end pointsBone mineral densityUse of hormonesHormone therapySkeletal benefitsRandomized trialsSuch therapyMineral densitySkeletal fracturesAbsolute reductionEnd pointStudy of hormonesWomenHealth careTrialsAgeTrue declineRisk