2020
Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery
Togioka BM, Yanez D, Aziz MF, Higgins JR, Tekkali P, Treggiari MM. Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery. British Journal Of Anaesthesia 2020, 124: 553-561. PMID: 32139135, DOI: 10.1016/j.bja.2020.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCholinesterase InhibitorsDelayed Emergence from AnesthesiaDouble-Blind MethodFemaleHumansIntraoperative PeriodLung DiseasesMaleNeostigmineNeuromuscular BlockadeNeuromuscular JunctionNeuromuscular Nondepolarizing AgentsPatient ReadmissionPostoperative ComplicationsRocuroniumSugammadexConceptsPostoperative pulmonary complicationsResidual neuromuscular blockPulmonary complicationsDay hospital readmissionNeuromuscular blockPrimary endpointHospital readmissionDay hospital readmission rateOlder adultsHospital readmission ratesPhase 1 recoveryRocuronium reversalNeostigmine groupSecondary endpointsSugammadex groupReadmission ratesResidual paralysisSurgical closureSugammadexComplicationsNeostigmineLarger studySurgeryIncidenceEndpoint
2018
Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine
Thilen SR, Ng IC, Cain KC, Treggiari MM, Bhananker SM. Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine. British Journal Of Anaesthesia 2018, 121: 367-377. PMID: 30032875, DOI: 10.1016/j.bja.2018.03.029.Peer-Reviewed Original ResearchConceptsPostoperative residual neuromuscular blockResidual neuromuscular blockNeuromuscular blockTracheal extubationNeostigmine reversalRocuronium neuromuscular blockIdeal body weightConfidence intervalsNeostigmine administrationRocuronium administrationSecondary endpointsAppropriate dosingAbdominal surgeryFemale sexDose reductionExtubationBody weightControl groupPatientsIncidenceSurgical requirementsSignificant differencesNeostigmineAdministrationSubjective monitoring
2015
Comparison of train-of-four count by anesthesia providers versus TOF-Watch® SX: a prospective cohort study
Bhananker SM, Treggiari MM, Sellers BA, Cain KC, Ramaiah R, Thilen SR. Comparison of train-of-four count by anesthesia providers versus TOF-Watch® SX: a prospective cohort study. Journal Canadien D'anesthésie 2015, 62: 1089-1096. PMID: 26224034, DOI: 10.1007/s12630-015-0433-9.Peer-Reviewed Original ResearchConceptsTOF-Watch SXTOF countNeuromuscular blockadeReversal agentsAnesthesia providersCohort studyTOF-WatchMethodsThis prospective observational cohort studyAnesthesiologists physical status IIIProspective observational cohort studyDose of rocuroniumObservational cohort studyProspective cohort studyComparison of TrainPremature administrationInadequate dosingElective surgeryBlockadeDoseAmerican SocietyPatientsCountSubjective assessmentProvidersLower counts