2009
Which H is the most important in triple-H therapy for cerebral vasospasm?
Treggiari MM, Deem S. Which H is the most important in triple-H therapy for cerebral vasospasm? Current Opinion In Critical Care 2009, 15: 83-86. PMID: 19276798, DOI: 10.1097/mcc.0b013e32832922d1.Peer-Reviewed Original ResearchMeSH KeywordsBlood CirculationBlood VolumeCerebrovascular CirculationHemodilutionHemodynamicsHumansHypertensionSubarachnoid HemorrhageVasospasm, IntracranialConceptsCerebral vasospasmSubarachnoid hemorrhageCirculatory volume expansionNew randomized trialsCerebral blood flowHemodynamic managementRandomized trialsHemodynamic variablesHypervolemic hemodilutionRegistry databaseBlood flowPaucity of informationVasospasmPhysiologic dataHemorrhagePhysiological studiesLow levelsHypertensionComplicationsHemodilutionTherapyRecent literatureTrials
2008
Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery
Lee LA, Deem S, Glenny RW, Townsend I, Moulding J, An D, Treggiari MM, Lam A. Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery. Anesthesiology 2008, 108: 864-872. PMID: 18431122, DOI: 10.1097/aln.0b013e31816c8a30.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaAnimalsBlood Flow VelocityCerebrovascular CirculationDisease Models, AnimalHypotensionIsofluraneMicrospheresOptic NerveOxygen ConsumptionRegional Blood FlowSwineConceptsCerebral blood flowOptic nerve blood flowNerve blood flowBlood flowCerebral DO2Venous congestionHypovolemic hypotensionOxygen deliveryPerioperative ischemic optic neuropathyCompensatory mechanismsStable cerebral blood flowIschemic optic neuropathyMajor surgical proceduresEffect of anemiaConditions of hypotensionSignificant reductionOptic neuropathyHypotensionSurgical proceduresControl animalsAnemiaFarm-raised pigsPhysiologic perturbationsDO2Significant increase
2006
Cerebral Autoregulation and CO2 Reactivity in Anterior and Posterior Cerebral Circulation During Sevoflurane Anesthesia
Rozet I, Vavilala MS, Lindley AM, Visco E, Treggiari M, Lam AM. Cerebral Autoregulation and CO2 Reactivity in Anterior and Posterior Cerebral Circulation During Sevoflurane Anesthesia. Anesthesia & Analgesia 2006, 102: 560-564. PMID: 16428561, DOI: 10.1213/01.ane.0000184817.10595.62.Peer-Reviewed Original ResearchConceptsCerebral autoregulationAutoregulatory indexBasilar arterySevoflurane anesthesiaHg PaCO2ASA physical status I patientsSmall-dose remifentanilCO2 reactivityElective orthopaedic surgeryArterial blood pressureMiddle cerebral arteryPosterior cerebral circulationStatus I patientsTranscranial Doppler ultrasonographyMAC of sevofluraneBlood flow velocityBlood pressurePosterior circulationCerebral arteryCerebral circulationI patientsPhenylephrine infusionDoppler ultrasonographyHealthy individualsLinear regression analysis