2016
Characteristics of Sepsis-Induced Cardiac Dysfunction using Speckle-Tracking Echocardiography: A Feasibility Study
Zaky A, Gill EA, Lin CP, Paul CP, Bendjelid K, Treggiari MM. Characteristics of Sepsis-Induced Cardiac Dysfunction using Speckle-Tracking Echocardiography: A Feasibility Study. Anaesthesia And Intensive Care 2016, 44: 65-76. PMID: 26673591, PMCID: PMC5050013, DOI: 10.1177/0310057x1604400111.Peer-Reviewed Original ResearchConceptsLeft ventricular longitudinal strainGlobal left ventricular longitudinal strainEjection fractionSepsis outcomeSepsis-Induced Cardiac DysfunctionLeft ventricular ejection fractionTwo-dimensional speckle trackingBasal anterior segmentLow ejection fractionPrimary study endpointTertiary care centerObservational feasibility studyVentricular ejection fractionDiagnosis of sepsisVentricular longitudinal strainSpeckle-tracking echocardiographyRisk of mortalitySpeckle tracking echocardiographyEnd-diastolic volumeMitral annular displacementLeft ventricular segmentsHospital mortalityHospital lengthHospital staySevere sepsis
2013
Etomidate, Adrenal Function, and Mortality in Critically Ill Patients
Sunshine JE, Deem S, Weiss NS, Yanez ND, Daniel S, Keech K, Brown M, Treggiari MM. Etomidate, Adrenal Function, and Mortality in Critically Ill Patients. Respiratory Care 2013, 58: 639-646. PMID: 22906838, PMCID: PMC4126750, DOI: 10.4187/respcare.01956.Peer-Reviewed Original ResearchConceptsCritical illness-related corticosteroid insufficiencyIll patientsCorticosteroid insufficiencyHospital mortalityAdrenal functionInduction agentAdrenal function testingPrevious randomized studyRole of etomidateRetrospective cohort studyBaseline illness severityRisk of deathAlternative induction agentHigh-risk populationRisk of mortalitySmall randomized trialsAcademic medical centerNumber of deathsEtomidate administrationEtomidate exposureAdjusted riskCohort studySecondary outcomesOverall mortalityPrimary outcome