2008
Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery
Lee LA, Deem S, Glenny RW, Townsend I, Moulding J, An D, Treggiari MM, Lam A. Effects of Anemia and Hypotension on Porcine Optic Nerve Blood Flow and Oxygen Delivery. Anesthesiology 2008, 108: 864-872. PMID: 18431122, DOI: 10.1097/aln.0b013e31816c8a30.Peer-Reviewed Original ResearchConceptsCerebral blood flowOptic nerve blood flowNerve blood flowBlood flowCerebral DO2Venous congestionHypovolemic hypotensionOxygen deliveryPerioperative ischemic optic neuropathyCompensatory mechanismsStable cerebral blood flowIschemic optic neuropathyMajor surgical proceduresEffect of anemiaConditions of hypotensionSignificant reductionOptic neuropathyHypotensionSurgical proceduresControl animalsAnemiaFarm-raised pigsPhysiologic perturbationsDO2Significant increase
2006
Cerebral Autoregulation and CO2 Reactivity in Anterior and Posterior Cerebral Circulation During Sevoflurane Anesthesia
Rozet I, Vavilala MS, Lindley AM, Visco E, Treggiari M, Lam AM. Cerebral Autoregulation and CO2 Reactivity in Anterior and Posterior Cerebral Circulation During Sevoflurane Anesthesia. Anesthesia & Analgesia 2006, 102: 560-564. PMID: 16428561, DOI: 10.1213/01.ane.0000184817.10595.62.Peer-Reviewed Original ResearchConceptsCerebral autoregulationAutoregulatory indexBasilar arterySevoflurane anesthesiaHg PaCO2ASA physical status I patientsSmall-dose remifentanilCO2 reactivityElective orthopaedic surgeryArterial blood pressureMiddle cerebral arteryPosterior cerebral circulationStatus I patientsTranscranial Doppler ultrasonographyMAC of sevofluraneBlood flow velocityBlood pressurePosterior circulationCerebral arteryCerebral circulationI patientsPhenylephrine infusionDoppler ultrasonographyHealthy individualsLinear regression analysis