2022
Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesia, ObstetricalAnesthetics, LocalFemaleHumansInfant, NewbornPregnancyProcaineProspective StudiesConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2018
Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine
Thilen SR, Ng IC, Cain KC, Treggiari MM, Bhananker SM. Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine. British Journal Of Anaesthesia 2018, 121: 367-377. PMID: 30032875, DOI: 10.1016/j.bja.2018.03.029.Peer-Reviewed Original ResearchConceptsPostoperative residual neuromuscular blockResidual neuromuscular blockNeuromuscular blockTracheal extubationNeostigmine reversalRocuronium neuromuscular blockIdeal body weightConfidence intervalsNeostigmine administrationRocuronium administrationSecondary endpointsAppropriate dosingAbdominal surgeryFemale sexDose reductionExtubationBody weightControl groupPatientsIncidenceSurgical requirementsSignificant differencesNeostigmineAdministrationSubjective monitoring
2015
Comparison of train-of-four count by anesthesia providers versus TOF-Watch® SX: a prospective cohort study
Bhananker SM, Treggiari MM, Sellers BA, Cain KC, Ramaiah R, Thilen SR. Comparison of train-of-four count by anesthesia providers versus TOF-Watch® SX: a prospective cohort study. Journal Canadien D'anesthésie 2015, 62: 1089-1096. PMID: 26224034, DOI: 10.1007/s12630-015-0433-9.Peer-Reviewed Original ResearchConceptsTOF-Watch SXTOF countNeuromuscular blockadeReversal agentsAnesthesia providersCohort studyTOF-WatchMethodsThis prospective observational cohort studyAnesthesiologists physical status IIIProspective observational cohort studyDose of rocuroniumObservational cohort studyProspective cohort studyComparison of TrainPremature administrationInadequate dosingElective surgeryBlockadeDoseAmerican SocietyPatientsCountSubjective assessmentProvidersLower counts
2013
Standard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis
Mayer‐Hamblett N, Rosenfeld M, Treggiari MM, Konstan MW, Retsch‐Bogart G, Morgan W, Wagener J, Gibson RL, Khan U, Emerson J, Thompson V, Elkin EP, Ramsey BW, for the EPIC E. Standard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis. Pediatric Pulmonology 2013, 48: 943-953. PMID: 23818295, PMCID: PMC4059359, DOI: 10.1002/ppul.22693.Peer-Reviewed Original ResearchConceptsTobramycin inhalation solutionHistorical controlsCystic fibrosisTrial participantsCulture positivityPA recurrenceDifferent antibiotic regimensHistorical control cohortInitial eradication therapyIncidence of hospitalizationStandard of careAntibiotic regimensEradication therapyRespiratory symptomsStandard careHospitalization outcomesHospitalization ratesCare treatmentControl cohortInhalation solutionAntimicrobial therapyClinical trialsEpidemiologic studiesInfection controlEligibility criteria
2012
Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury
Badri S, Chen J, Barber J, Temkin NR, Dikmen SS, Chesnut RM, Deem S, Yanez ND, Treggiari MM. Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. Intensive Care Medicine 2012, 38: 1800-1809. PMID: 23011528, DOI: 10.1007/s00134-012-2655-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAverage intracranial pressureIntracranial pressureFunctional statusTBI patientsBrain injuryNeuropsychological functioningAbbreviated Injury Scale headLong-term functional outcomeSevere traumatic brain injuryAdult TBI patientsInjury scale headGlasgow Coma ScoreSevere TBI patientsPrimary endpointComa ScoreComposite endpointIndependent predictorsFunctional outcomeOdds ratioMultivariable regressionNeuropsychological outcomesNeuropsychological testingPatientsNeuropsychological function
2009
Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome
Treggiari MM, Bendjelid K, Yanez ND, Heidegger CP, Suter PM, Romand JA. Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome. Journal Of Critical Care 2009, 25: 23-29. PMID: 19327320, DOI: 10.1016/j.jcrc.2008.10.014.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeAtrial natriuretic peptideBaseline atrial natriuretic peptideRespiratory distress syndromeNT-proNatriuretic peptideBNP concentrationsDistress syndromeCardiac peptidesHigh atrial natriuretic peptideBrain natriuretic peptide concentrationsB-type natriuretic peptideNitric oxideCyclic guanosine monophosphate concentrationBaseline NT-proProspective cohort studyNatriuretic peptide concentrationsSubgroup of patientsCardiac natriuretic peptidesGuanosine monophosphate concentrationCyclic guanosine monophosphateIntrapulmonary shuntCohort studyConsecutive patientsClinical benefit
2008
The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury
Cooke CR, Watkins TR, Kahn JM, Treggiari MM, Caldwell E, Hudson LD, Rubenfeld GD. The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Critical Care 2008, 12: r134. PMID: 18980682, PMCID: PMC2646342, DOI: 10.1186/cc7105.Peer-Reviewed Original ResearchConceptsClosed intensive care unitAcute lung injuryIntensive care unitLung injuryCare unitTidal volumeProspective population-based cohortLow VTOpen intensive care unitIntensivist physician staffingPopulation-based cohortProcess of careHospital mortalityVentilatory practicesImproved mortalityIntensive carePhysician staffingPatient outcomesMean VTPatientsDay threeSecondary analysisPotential patientsHigh VTKing County
2004
Transpulmonary lactate gradient after hypothermic cardiopulmonary bypass
Bendjelid K, Treggiari MM, Romand JA. Transpulmonary lactate gradient after hypothermic cardiopulmonary bypass. Intensive Care Medicine 2004, 30: 817-821. PMID: 14985958, DOI: 10.1007/s00134-004-2179-7.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypass durationAcute lung injuryPulmonary lactate releaseCardiopulmonary bypassBypass durationLactate releaseAortic cross-clamping timeEffects of CPBPost-cardiac surgery patientsCross-clamping timePulmonary artery catheterVenous blood samplesHypothermic cardiopulmonary bypassConclusionThe present studyPulmonary releaseCardiac indexArtery catheterLung injurySurgery patientsSurgical ICUMechanical ventilationCardiac outputUniversity HospitalBlood samplesPatientsEffect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*
Treggiari MM, Hudson LD, Martin DP, Weiss NS, Caldwell E, Rubenfeld G. Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients*. Critical Care Medicine 2004, 32: 327-331. PMID: 14758144, DOI: 10.1097/01.ccm.0000108870.09693.42.Peer-Reviewed Original ResearchMeSH KeywordsAdultCosts and Cost AnalysisCritical IllnessFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRespiratory Distress SyndromeWounds and InjuriesConceptsALI/acute respiratory distress syndromeAcute respiratory distress syndromeAcute lung injuryAcute Physiology ScoreRespiratory distress syndromeTrauma patientsHospital mortalityPhysiology ScoreLung injuryDistress syndromeSeverity scoreHospital costsTrauma severityAmerican-European Consensus Conference definitionPresence of ALIIntensive care unit admissionIntensive care unit stayIll trauma patientsCare unit admissionInjury Severity ScoreConsensus Conference definitionLevel I centersCrude relative riskIntensive care unitLength of stay